Showing entry for 2'-5'-oligoadenylate synthase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005711
Protein Name2'-5'-oligoadenylate synthase 1
Uniport IdP00973
GeneOAS1
Gene Id4938
DomainNTP_transf_2; OAS1_C
Pfam PF01909   PF10421  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035457 cellular response to interferon-alpha
Biological Process GO:0051607 defense response to virus
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0060333 interferon-gamma-mediated signaling pathway
Biological Process GO:0045071 negative regulation of viral genome replication
Biological Process GO:0051259 protein complex oligomerization
Biological Process GO:0006164 purine nucleotide biosynthetic process
Biological Process GO:0060700 regulation of ribonuclease activity
Biological Process GO:0009615 response to virus
Biological Process GO:0060337 type I interferon signaling pathway
molecular function GO:0001730 2'-5'-oligoadenylate synthetase activity
molecular function GO:0005524 ATP binding
molecular function GO:0003725 double-stranded RNA binding
molecular function GO:0046872 metal ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005576 extracellular region
cellular component GO:0016020 membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System
R-HSA-877300 Interferon gamma signaling
R-HSA-8983711 OAS antiviral response
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-913531 Interferon Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0008055 BXGD000514 Chikungunya Fever Infections
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011311 BXGD000714 Dengue Fever Infections
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014060 BXGD000882 Encephalitis, St. Louis Infections; Nervous System Diseases
C0016382 BXGD001054 Flushing Pathological Conditions, Signs and Symptoms
C0018572 BXGD001206 Hand, Foot and Mouth Disease Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0034050 BXGD002452 Pulmonary Alveolar Proteinosis Respiratory Tract Diseases
C0034642 BXGD002485 Rales Pathological Conditions, Signs and Symptoms
C0035920 BXGD002570 Rubella Infections
C0039231 BXGD002799 Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042769 BXGD002999 Virus Diseases Infections
C0043124 BXGD003031 West Nile Fever Infections; Nervous System Diseases
C0079218 BXGD003066 Fibromatosis, Aggressive Neoplasms
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0086438 BXGD003283 Hypogammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C0152517 BXGD003604 Viral gastroenteritis Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Infections
C0200635 BXGD004041 Lymphocyte Count measurement
C0202035 BXGD004066 Gamma glutamyl transferase measurement
C0202239 BXGD004087 Uric acid measurement (procedure)
C0231835 BXGD004527 Tachypnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0275524 BXGD006376 Coinfection Infections
C0276447 BXGD006425 Rhinovirus infection Infections
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410005 BXGD008407 Nodular fasciitis Neoplasms; Musculoskeletal Diseases; Nervous System Diseases
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0700292 BXGD009884 Hypoxemia Pathological Conditions, Signs and Symptoms
C0751583 BXGD010509 Encephalitis, West Nile Fever Infections; Nervous System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C1096184 BXGD011607 West Nile viral infection Infections; Nervous System Diseases
C1175175 BXGD011797 Severe Acute Respiratory Syndrome Infections; Respiratory Tract Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1278049 BXGD012114 Serum gamma-glutamyl transferase measurement
C1510475 BXGD013171 Diverticulosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1527390 BXGD013285 Neoplasms, Intracranial Neoplasms; Nervous System Diseases
C1867873 BXGD016473 Failure to thrive in infancy
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931035 BXGD017942 Pulmonary alveolar proteinosis, congenital Respiratory Tract Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3277226 BXGD018711 Restrictive ventilatory defect
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3714514 BXGD019409 Infection Infections
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4022660 BXGD020947 Autoimmune antibody positivity
C4023112 BXGD021110 Acute infectious pneumonia
C4025279 BXGD021620 Respiratory failure requiring assisted ventilation Respiratory Tract Diseases
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4281786 BXGD022416 Presence of foam cells Cardiovascular Diseases
C4476749 BXGD022860 Crazy paving pattern on pulmonary HRCT
C4476917 BXGD022889 Elevated carcinoembryonic antigen level
C4747984 BXGD023976 PULMONARY ALVEOLAR PROTEINOSIS WITH HYPOGAMMAGLOBULINEMIA
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein