Showing entry for Low-density lipoprotein receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005735
Protein NameLow-density lipoprotein receptor
Uniport IdP01130
GeneLDLR
Gene Id3949
DomaincEGF; FXa_inhibition; Ldl_recept_a; Ldl_recept_b
Pfam PF07645   PF00057   PF00058  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.2 Endocrine system hsa04913 Ovarian steroidogenesis
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
5. Organismal Systems 5.4 Digestive system hsa04979 Cholesterol metabolism
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05145 Toxoplasmosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0097242 amyloid-beta clearance
Biological Process GO:0150094 amyloid-beta clearance by cellular catabolic process
Biological Process GO:0048844 artery morphogenesis
Biological Process GO:0071398 cellular response to fatty acid
Biological Process GO:0071404 cellular response to low-density lipoprotein particle stimulus
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0070508 cholesterol import
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0030301 cholesterol transport
Biological Process GO:0034382 chylomicron remnant clearance
Biological Process GO:0006897 endocytosis
Biological Process GO:0034384 high-density lipoprotein particle clearance
Biological Process GO:0030299 intestinal cholesterol absorption
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0042159 lipoprotein catabolic process
Biological Process GO:0007616 long-term memory
Biological Process GO:0034383 low-density lipoprotein particle clearance
Biological Process GO:0061024 membrane organization
Biological Process GO:1905907 negative regulation of amyloid fibril formation
Biological Process GO:0061889 negative regulation of astrocyte activation
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:1903979 negative regulation of microglial cell activation
Biological Process GO:0051248 negative regulation of protein metabolic process
Biological Process GO:0006909 phagocytosis
Biological Process GO:0015914 phospholipid transport
Biological Process GO:0034381 plasma lipoprotein particle clearance
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:1905167 positive regulation of lysosomal protein catabolic process
Biological Process GO:0010867 positive regulation of triglyceride biosynthetic process
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
Biological Process GO:0090181 regulation of cholesterol metabolic process
Biological Process GO:0010899 regulation of phosphatidylcholine catabolic process
Biological Process GO:0051246 regulation of protein metabolic process
Biological Process GO:0061771 response to caloric restriction
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0032050 clathrin heavy chain binding
molecular function GO:0042802 identical protein binding
molecular function GO:0030169 low-density lipoprotein particle binding
molecular function GO:0005041 low-density lipoprotein particle receptor activity
molecular function GO:0002020 protease binding
molecular function GO:0030229 very-low-density lipoprotein particle receptor activity
molecular function GO:0001618 virus receptor activity
cellular component GO:0045177 apical part of cell
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0009986 cell surface
cellular component GO:0030669 clathrin-coated endocytic vesicle membrane
cellular component GO:0005905 clathrin-coated pit
cellular component GO:0005769 early endosome
cellular component GO:0036020 endolysosome membrane
cellular component GO:0010008 endosome membrane
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005770 late endosome
cellular component GO:0034362 low-density lipoprotein particle
cellular component GO:0005764 lysosome
cellular component GO:0016020 membrane
cellular component GO:1990666 PCSK9-LDLR complex
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
cellular component GO:0036477 somatodendritic compartment
cellular component GO:0097443 sorting endosome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-199991 Membrane Trafficking
R-HSA-2187338 Visual phototransduction
R-HSA-372790 Signaling by GPCR
R-HSA-382551 Transport of small molecules
R-HSA-382551 Transport of small molecules
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-5653656 Vesicle-mediated transport
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8964026 Chylomicron clearance
R-HSA-8964026 Chylomicron clearance
R-HSA-8964038 LDL clearance
R-HSA-8964043 Plasma lipoprotein clearance
R-HSA-8964043 Plasma lipoprotein clearance
R-HSA-975634 Retinoid metabolism and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000744 BXGD000006 Abetalipoproteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0001175 BXGD000029 Acquired Immunodeficiency Syndrome Infections; Immune System Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002962 BXGD000160 Angina Pectoris Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003125 BXGD000179 Anorexia Nervosa Mental Disorders
C0003499 BXGD000201 Supravalvular aortic stenosis Cardiovascular Diseases
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0003742 BXGD000218 Arcus Senilis Eye Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005396 BXGD000310 Bile Duct Neoplasms Digestive System Diseases; Neoplasms
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0009443 BXGD000612 Common Cold Infections; Respiratory Tract Diseases
C0010051 BXGD000646 Coronary Aneurysm Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0014060 BXGD000882 Encephalitis, St. Louis Infections; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014527 BXGD000923 Epidermolysis Bullosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0015306 BXGD000975 Hereditary Multiple Exostoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015696 BXGD001014 Fatty Liver, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018808 BXGD001229 Heart murmur Pathological Conditions, Signs and Symptoms
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020175 BXGD001362 Hunger Behavior and Behavior Mechanisms
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020474 BXGD001397 Hyperlipidemia, Familial Combined Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020476 BXGD001398 Hyperlipoproteinemias Nutritional and Metabolic Diseases
C0020479 BXGD001399 Hyperlipoproteinemia Type III Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020507 BXGD001413 Hyperplasia Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0020597 BXGD001439 Hypobetalipoproteinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023343 BXGD001635 Leprosy Infections
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023827 BXGD001707 liposarcoma Neoplasms
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024530 BXGD001783 Malaria Infections
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026266 BXGD001895 Mitral Valve Insufficiency Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027126 BXGD001976 Myotonic Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029132 BXGD002117 Disorder of the optic nerve Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030499 BXGD002232 Parasitic Diseases Infections
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033626 BXGD002412 Protein Deficiency Nutritional and Metabolic Diseases
C0033999 BXGD002448 Pterygium Eye Diseases
C0034362 BXGD002479 Q Fever Infections
C0035067 BXGD002504 Renal Artery Stenosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039292 BXGD002807 Tangier Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042870 BXGD003008 Vitamin D Deficiency Nutritional and Metabolic Diseases
C0043325 BXGD003041 Xanthomatosis Nutritional and Metabolic Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085220 BXGD003142 Cerebral Amyloid Angiopathy Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085436 BXGD003177 Meningitis, Cryptococcal Infections; Nervous System Diseases
C0085576 BXGD003188 Iron-Refractory Iron Deficiency Anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0086942 BXGD003315 Rous Sarcoma Neoplasms; Infections; Animal Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151718 BXGD003464 Hypocholesterolemia Nutritional and Metabolic Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0151826 BXGD003482 Retrosternal pain Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152255 BXGD003574 Pinguecula Eye Diseases
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0154723 BXGD003737 Migraine with Aura Nervous System Diseases
C0155210 BXGD003780 Eyelid Xanthoma Nutritional and Metabolic Diseases; Eye Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0155733 BXGD003815 Atherosclerosis of aorta Cardiovascular Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0175694 BXGD004002 Smith-Lemli-Opitz Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220756 BXGD004338 Niemann-Pick Disease, Type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0221253 BXGD004422 Xanthoma tendinosum Nutritional and Metabolic Diseases
C0238052 BXGD004866 Xanthomatosis, Cerebrotendinous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242073 BXGD005134 Pulmonary congestion Respiratory Tract Diseases; Cardiovascular Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242698 BXGD005189 Ventricular Dysfunction, Left Cardiovascular Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0243038 BXGD005211 Carcinoma, Lewis Lung Neoplasms
C0263420 BXGD005303 Hyperkeratosis lenticularis perstans Skin and Connective Tissue Diseases
C0265101 BXGD005454 Carotid artery occlusion Nervous System Diseases; Cardiovascular Diseases
C0267818 BXGD005781 Bile duct proliferation Digestive System Diseases
C0268601 BXGD006002 HMG CoA lyase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268731 BXGD006029 Renal glomerular disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0276447 BXGD006425 Rhinovirus infection Infections
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278608 BXGD006549 Adult Liposarcoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279984 BXGD006703 Childhood Liposarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0302314 BXGD006837 Xanthoma Nutritional and Metabolic Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338460 BXGD007179 Argyrophilic grain disease
C0338480 BXGD007186 Common Migraine Nervous System Diseases
C0338585 BXGD007202 Dissection of carotid artery Nervous System Diseases; Cardiovascular Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339143 BXGD007226 Thyroid associated opthalmopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0342879 BXGD007570 Primary hypercholesterolemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0342880 BXGD007571 Polygenic hypercholesterolemia
C0342881 BXGD007572 Familial hypercholesterolemia - homozygous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0342882 BXGD007573 Familial hypercholesterolemia - heterozygous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0410480 BXGD008429 Avascular Necrosis of Femur Head Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0410529 BXGD008431 Hypochondroplasia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0428791 BXGD008635 Aortic valve calcification Nutritional and Metabolic Diseases; Cardiovascular Diseases
C0432252 BXGD008755 Osteoporosis with pseudoglioma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0473527 BXGD008939 Hypoalphalipoproteinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0519066 BXGD009080 Acute Q fever Infections
C0523465 BXGD009209 Serum albumin measurement
C0523744 BXGD009217 Lipids measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0549399 BXGD009376 Low density lipoprotein increased Nutritional and Metabolic Diseases
C0577631 BXGD009535 Carotid Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0596848 BXGD009647 lipoprotein disorder Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0598784 BXGD009670 Dyslipoproteinemias Nutritional and Metabolic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700639 BXGD009899 Pyloric Stenosis, Hypertrophic Digestive System Diseases
C0740277 BXGD009972 Bile duct carcinoma Digestive System Diseases; Neoplasms
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0741026 BXGD010022 Atypical angina Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0741923 BXGD010045 cardiac event
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751815 BXGD010597 Carotid Artery, Internal, Dissection Nervous System Diseases; Cardiovascular Diseases; Wounds and Injuries
C0853689 BXGD010977 Secondary hyperlipidemia Nutritional and Metabolic Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0878552 BXGD011369 Coronary artery ectasia
C0947622 BXGD011493 Cholecystolithiasis Digestive System Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C0948192 BXGD011514 Primary infection NOS
C0948242 BXGD011519 Nuchal bleb, familial Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C1096249 BXGD011612 Calcification of the aorta
C1168443 BXGD011794 Pseudocholinesterase Measurement
C1261287 BXGD011852 Stenosis Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C1273976 BXGD012020 First myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1275461 BXGD012086 Familial hypercholesterolemia due to genetic defect of apolipoprotein B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1301700 BXGD012296 Cardiovascular morbidity
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332347 BXGD012527 Atypical Ductal Breast Hyperplasia Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1390512 BXGD012970 Bone xanthoma Musculoskeletal Diseases
C1411966 BXGD013047 Clostridium; difficile (disorder)
C1443892 BXGD013073 Chronic Q Fever Infections
C1445957 BXGD013081 Serum total cholesterol measurement
C1512981 BXGD013196 Mammary Tumorigenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1522133 BXGD013252 Hypercholesterolemia result
C1536220 BXGD013341 ST segment elevation myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1563937 BXGD013397 Atherogenesis Cardiovascular Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611184 BXGD013455 Calcification of coronary artery Nutritional and Metabolic Diseases; Cardiovascular Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1704378 BXGD013554 Heymann Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C1704417 BXGD013557 Hyperlipoproteinemia Type IIb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1706412 BXGD013572 Lipidemias Nutritional and Metabolic Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1843366 BXGD014575 NIEMANN-PICK DISEASE, TYPE C2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C1848486 BXGD014929 Premature arteriosclerosis Cardiovascular Diseases
C1860488 BXGD015986 Abnormal internal carotid artery morphology
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C1862941 BXGD016145 Amyotrophic Lateral Sclerosis, Sporadic Nutritional and Metabolic Diseases; Nervous System Diseases
C1863512 BXGD016181 HYPERCHOLESTEROLEMIA, AUTOSOMAL RECESSIVE Nutritional and Metabolic Diseases
C1864172 BXGD016217 Peroxisome Biogenesis Disorder, Complementation Group G Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1867441 BXGD016455 Pterygium Of Conjunctiva And Cornea Eye Diseases
C1867743 BXGD016470 Premature coronary artery atherosclerosis Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2673196 BXGD017189 LIPOPROTEIN GLOMERULOPATHY Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2675518 BXGD017297 Adiponectin Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2733158 BXGD017562 Cerebral Small Vessel Diseases Nervous System Diseases; Cardiovascular Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2931852 BXGD018079 Clear-cell metastatic renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2939465 BXGD018182 Deficiency of glucose-6-phosphate dehydrogenase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C2973787 BXGD018206 Coxiella burnetii Infection Infections
C3151466 BXGD018434 HEPATIC LIPASE DEFICIENCY (disorder) Nutritional and Metabolic Diseases
C3160761 BXGD018475 Diabetic dyslipidaemia
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3665365 BXGD019282 Arteriosclerotic cardiovascular disease, NOS Cardiovascular Diseases
C3714514 BXGD019409 Infection Infections
C3714796 BXGD019434 Isolated somatotropin deficiency
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C3888506 BXGD019974 LDLR mutation
C4021654 BXGD020722 Precocious atherosclerosis Cardiovascular Diseases
C4021796 BXGD020786 Renal steatosis
C4022811 BXGD021006 Abnormality of nervous system physiology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4022924 BXGD021040 Abnormal eye physiology
C4024924 BXGD021477 Cerebral artery atherosclerosis Cardiovascular Diseases
C4025000 BXGD021519 Myocardial steatosis
C4025272 BXGD021615 Peripheral arterial stenosis
C4054546 BXGD021984 Melanocortin 4 Receptor Deficiency
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4229399 BXGD022294 Early-onset coronary artery disease
C4255010 BXGD022310 Non-ST Elevated Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4316899 BXGD022710 Cystinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4476910 BXGD022887 Thin-cap fibroatheroma Cardiovascular Diseases
C4505456 BXGD022964 HIV Coinfection Infections; Immune System Diseases
C4509226 BXGD022972 Heart failure with preserved ejection fraction [HFpEF]
C4520843 BXGD023043 Pterygium of eye Eye Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4551993 BXGD023469 Amyotrophic Lateral Sclerosis, Familial Nutritional and Metabolic Diseases; Nervous System Diseases
C4699152 BXGD023634 ST-segment elevation myocardial infarction (STEMI)
C4700045 BXGD023640 Non-ST-segment elevation myocardial infarction (NSTEMI)
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0018397 beta-1,4-mannan 180.06
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein