Showing entry for Cellular tumor antigen p53



                       
General Target Information
BXGT IdBXGT005875
Protein NameCellular tumor antigen p53
Uniport IdP02340
GeneTp53
Gene Id22059
DomainP53; P53_TAD; P53_tetramer
Pfam PF00870   PF08563   PF07710  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006914 autophagy
Biological Process GO:0002326 B cell lineage commitment
Biological Process GO:0048539 bone marrow development
Biological Process GO:0060411 cardiac septum morphogenesis
Biological Process GO:0007569 cell aging
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0034613 cellular protein localization
Biological Process GO:0072717 cellular response to actinomycin D
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0071480 cellular response to gamma radiation
Biological Process GO:0042149 cellular response to glucose starvation
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0071479 cellular response to ionizing radiation
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0034644 cellular response to UV
Biological Process GO:0071494 cellular response to UV-C
Biological Process GO:0007417 central nervous system development
Biological Process GO:0021549 cerebellum development
Biological Process GO:0031497 chromatin assembly
Biological Process GO:0051276 chromosome organization
Biological Process GO:0048512 circadian behavior
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0008340 determination of adult lifespan
Biological Process GO:0030330 DNA damage response, signal transduction by p53 class mediator
Biological Process GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Biological Process GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Biological Process GO:0000733 DNA strand renaturation
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0009792 embryo development ending in birth or egg hatching
Biological Process GO:0048568 embryonic organ development
Biological Process GO:0043153 entrainment of circadian clock by photoperiod
Biological Process GO:0006983 ER overload response
Biological Process GO:0007369 gastrulation
Biological Process GO:0007507 heart development
Biological Process GO:0002244 hematopoietic progenitor cell differentiation
Biological Process GO:0060218 hematopoietic stem cell differentiation
Biological Process GO:0060333 interferon-gamma-mediated signaling pathway
Biological Process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0043504 mitochondrial DNA repair
Biological Process GO:0071850 mitotic cell cycle arrest
Biological Process GO:0031571 mitotic G1 DNA damage checkpoint
Biological Process GO:0009299 mRNA transcription
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0070266 necroptotic process
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:2000279 negative regulation of DNA biosynthetic process
Biological Process GO:0008156 negative regulation of DNA replication
Biological Process GO:0048147 negative regulation of fibroblast proliferation
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:1904024 negative regulation of glucose catabolic process to lactate via pyruvate
Biological Process GO:1901525 negative regulation of mitophagy
Biological Process GO:0045930 negative regulation of mitotic cell cycle
Biological Process GO:0007406 negative regulation of neuroblast proliferation
Biological Process GO:1905856 negative regulation of pentose-phosphate shunt
Biological Process GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process GO:0045861 negative regulation of proteolysis
Biological Process GO:2000378 negative regulation of reactive oxygen species metabolic process
Biological Process GO:0048662 negative regulation of smooth muscle cell proliferation
Biological Process GO:0051974 negative regulation of telomerase activity
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0051402 neuron apoptotic process
Biological Process GO:0006289 nucleotide-excision repair
Biological Process GO:0097252 oligodendrocyte apoptotic process
Biological Process GO:0090403 oxidative stress-induced premature senescence
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0010666 positive regulation of cardiac muscle cell apoptotic process
Biological Process GO:0090343 positive regulation of cell aging
Biological Process GO:0045787 positive regulation of cell cycle
Biological Process GO:0071158 positive regulation of cell cycle arrest
Biological Process GO:1900119 positive regulation of execution phase of apoptosis
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0031065 positive regulation of histone deacetylation
Biological Process GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Biological Process GO:0002687 positive regulation of leukocyte migration
Biological Process GO:0035794 positive regulation of mitochondrial membrane permeability
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
Biological Process GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process GO:0062100 positive regulation of programmed necrotic cell death
Biological Process GO:2000379 positive regulation of reactive oxygen species metabolic process
Biological Process GO:0090200 positive regulation of release of cytochrome c from mitochondria
Biological Process GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
Biological Process GO:0070245 positive regulation of thymocyte apoptotic process
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Biological Process GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
Biological Process GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0008104 protein localization
Biological Process GO:0050821 protein stabilization
Biological Process GO:0051262 protein tetramerization
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:2000772 regulation of cellular senescence
Biological Process GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
Biological Process GO:2000269 regulation of fibroblast apoptotic process
Biological Process GO:1903205 regulation of hydrogen peroxide-induced cell death
Biological Process GO:0051453 regulation of intracellular pH
Biological Process GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
Biological Process GO:0043523 regulation of neuron apoptotic process
Biological Process GO:0070243 regulation of thymocyte apoptotic process
Biological Process GO:0034103 regulation of tissue remodeling
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:1990248 regulation of transcription from RNA polymerase II promoter in response to DNA damage
Biological Process GO:0001836 release of cytochrome c from mitochondria
Biological Process GO:0090399 replicative senescence
Biological Process GO:0043200 response to amino acid
Biological Process GO:0031000 response to caffeine
Biological Process GO:0042493 response to drug
Biological Process GO:0045471 response to ethanol
Biological Process GO:0010332 response to gamma radiation
Biological Process GO:0055093 response to hyperoxia
Biological Process GO:0002931 response to ischemia
Biological Process GO:0010038 response to metal ion
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0032526 response to retinoic acid
Biological Process GO:0009651 response to salt stress
Biological Process GO:0009411 response to UV
Biological Process GO:0010224 response to UV-B
Biological Process GO:0033552 response to vitamin B3
Biological Process GO:0010165 response to X-ray
Biological Process GO:0009303 rRNA transcription
Biological Process GO:0072331 signal transduction by p53 class mediator
Biological Process GO:0001756 somitogenesis
Biological Process GO:0033077 T cell differentiation in thymus
Biological Process GO:0002360 T cell lineage commitment
Biological Process GO:0002309 T cell proliferation involved in immune response
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
Biological Process GO:0016032 viral process
Biological Process GO:0042060 wound healing
molecular function GO:0005524 ATP binding
molecular function GO:0051087 chaperone binding
molecular function GO:0003682 chromatin binding
molecular function GO:0005507 copper ion binding
molecular function GO:0001046 core promoter sequence-specific DNA binding
molecular function GO:0097718 disordered domain specific binding
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0019899 enzyme binding
molecular function GO:0035035 histone acetyltransferase binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0035033 histone deacetylase regulator activity
molecular function GO:0042802 identical protein binding
molecular function GO:0097371 MDM2/MDM4 family protein binding
molecular function GO:0003730 mRNA 3'-UTR binding
molecular function GO:0002039 p53 binding
molecular function GO:1990841 promoter-specific chromatin binding
molecular function GO:0002020 protease binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0051721 protein phosphatase 2A binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0043621 protein self-association
molecular function GO:0030971 receptor tyrosine kinase binding
molecular function GO:0001102 RNA polymerase II activating transcription factor binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0001085 RNA polymerase II transcription factor binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0001094 TFIID-class transcription factor complex binding
molecular function GO:0001221 transcription cofactor binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0005813 centrosome
cellular component GO:0000785 chromatin
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
cellular component GO:0000790 nuclear chromatin
cellular component GO:0016363 nuclear matrix
cellular component GO:0031965 nuclear membrane
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0016605 PML body
cellular component GO:0032991 protein-containing complex
cellular component GO:0005657 replication fork
cellular component GO:0090575 RNA polymerase II transcription regulator complex
cellular component GO:0035861 site of double-strand break
cellular component GO:0005669 transcription factor TFIID complex
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001991 Juglone 174.15
BXGC0004266 2-Propanol 60.1
BXGC0021331 2-Methoxyjuglone 204.04
BXGC0043971 methylglucoside 194.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein