Showing entry for Apolipoprotein C-II


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005912
Protein NameApolipoprotein C-II
Uniport IdP02655
GeneAPOC2
Gene Id344
DomainApo-CII
Pfam PF05355  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.4 Digestive system hsa04979 Cholesterol metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0033344 cholesterol efflux
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0034378 chylomicron assembly
Biological Process GO:0034382 chylomicron remnant clearance
Biological Process GO:0034371 chylomicron remodeling
Biological Process GO:0034384 high-density lipoprotein particle clearance
Biological Process GO:0034375 high-density lipoprotein particle remodeling
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0042953 lipoprotein transport
Biological Process GO:0032375 negative regulation of cholesterol transport
Biological Process GO:0045833 negative regulation of lipid metabolic process
Biological Process GO:0048261 negative regulation of receptor-mediated endocytosis
Biological Process GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
Biological Process GO:0033700 phospholipid efflux
Biological Process GO:0045723 positive regulation of fatty acid biosynthetic process
Biological Process GO:0051006 positive regulation of lipoprotein lipase activity
Biological Process GO:0010518 positive regulation of phospholipase activity
Biological Process GO:0060697 positive regulation of phospholipid catabolic process
Biological Process GO:0010898 positive regulation of triglyceride catabolic process
Biological Process GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling
Biological Process GO:0042493 response to drug
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0043691 reverse cholesterol transport
Biological Process GO:0070328 triglyceride homeostasis
Biological Process GO:0034370 triglyceride-rich lipoprotein particle remodeling
Biological Process GO:0034372 very-low-density lipoprotein particle remodeling
molecular function GO:0042802 identical protein binding
molecular function GO:0055102 lipase inhibitor activity
molecular function GO:0008289 lipid binding
molecular function GO:0060230 lipoprotein lipase activator activity
molecular function GO:0016004 phospholipase activator activity
molecular function GO:0043274 phospholipase binding
cellular component GO:0042627 chylomicron
cellular component GO:0005769 early endosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0034363 intermediate-density lipoprotein particle
cellular component GO:0034362 low-density lipoprotein particle
cellular component GO:0034366 spherical high-density lipoprotein particle
cellular component GO:0034361 very-low-density lipoprotein particle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-2187338 Visual phototransduction
R-HSA-2187338 Visual phototransduction
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-382551 Transport of small molecules
R-HSA-382551 Transport of small molecules
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-8963888 Chylomicron assembly
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
R-HSA-8963898 Plasma lipoprotein assembly
R-HSA-8963899 Plasma lipoprotein remodeling
R-HSA-8963899 Plasma lipoprotein remodeling
R-HSA-8963901 Chylomicron remodeling
R-HSA-8964058 HDL remodeling
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-HSA-975634 Retinoid metabolism and transport
R-HSA-975634 Retinoid metabolism and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011609 BXGD000737 Drug Eruptions Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019207 BXGD001303 Hepatoma, Morris Digestive System Diseases; Neoplasms
C0019208 BXGD001304 Hepatoma, Novikoff Digestive System Diseases; Neoplasms
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020476 BXGD001398 Hyperlipoproteinemias Nutritional and Metabolic Diseases
C0020479 BXGD001399 Hyperlipoproteinemia Type III Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0020597 BXGD001439 Hypobetalipoproteinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0023462 BXGD001654 Acute Megakaryocytic Leukemias Neoplasms
C0023817 BXGD001706 Hyperlipoproteinemia Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0023904 BXGD001721 Liver Neoplasms, Experimental Digestive System Diseases; Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027126 BXGD001976 Myotonic Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0043325 BXGD003041 Xanthomatosis Nutritional and Metabolic Diseases
C0086404 BXGD003278 Experimental Hepatoma Digestive System Diseases; Neoplasms
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0221252 BXGD004421 Eruptive xanthoma Nutritional and Metabolic Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0268199 BXGD005853 Familial apolipoprotein C-II deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0302314 BXGD006837 Xanthoma Nutritional and Metabolic Diseases
C0339477 BXGD007251 Lipidemia retinalis Eye Diseases
C0406537 BXGD008348 Morbilliform Drug Reaction Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C0473527 BXGD008939 Hypoalphalipoproteinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1274228 BXGD012027 Chylomicronemia syndrome
C1291447 BXGD012214 Deficiency of triacylglycerol lipase
C1611743 BXGD013456 Familial (FPAH)
C1720779 BXGD013681 Apolipoprotein C-II Deficiency (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1862596 BXGD016135 Familial hypobetalipoproteinemia Nutritional and Metabolic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931862 BXGD018083 Familial hyperchylomicronemia syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2936349 BXGD018109 Plaque, Amyloid Pathological Conditions, Signs and Symptoms
C2985280 BXGD018223 Blood Protein Measurement
C3250443 BXGD018584 MYOTONIC DYSTROPHY 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3889891 BXGD020013 APOLIPOPROTEIN C-II (PADOVA) PHENOTYPE
C4017134 BXGD020415 APOLIPOPROTEIN C-II (PARIS) PHENOTYPE
C4017135 BXGD020416 APOLIPOPROTEIN C-II (BARI) PHENOTYPE
C4017136 BXGD020417 APOLIPOPROTEIN C-II VARIANT PHENOTYPE
C4017137 BXGD020418 APOLIPOPROTEIN C-II (SAN FRANCISCO)
C4017138 BXGD020419 apolipoprotein C-II (Wakayama) phenotype
C4017139 BXGD020420 APOLIPOPROTEIN C-II (AUCKLAND) PHENOTYPE
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551632 BXGD023377 Recurrent pancreatitis Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein