Showing entry for Apolipoprotein C-III


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005913
Protein NameApolipoprotein C-III
Uniport IdP02656
GeneAPOC3
Gene Id345
DomainApo-CIII
Pfam PF05778  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
5. Organismal Systems 5.4 Digestive system hsa04979 Cholesterol metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0033344 cholesterol efflux
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0034378 chylomicron assembly
Biological Process GO:0034382 chylomicron remnant clearance
Biological Process GO:0034371 chylomicron remodeling
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0034375 high-density lipoprotein particle remodeling
Biological Process GO:0042157 lipoprotein metabolic process
Biological Process GO:0060621 negative regulation of cholesterol import
Biological Process GO:0045717 negative regulation of fatty acid biosynthetic process
Biological Process GO:0010987 negative regulation of high-density lipoprotein particle clearance
Biological Process GO:0050995 negative regulation of lipid catabolic process
Biological Process GO:0045833 negative regulation of lipid metabolic process
Biological Process GO:0051005 negative regulation of lipoprotein lipase activity
Biological Process GO:0010989 negative regulation of low-density lipoprotein particle clearance
Biological Process GO:0048261 negative regulation of receptor-mediated endocytosis
Biological Process GO:0010897 negative regulation of triglyceride catabolic process
Biological Process GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
Biological Process GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
Biological Process GO:0033700 phospholipid efflux
Biological Process GO:0032489 regulation of Cdc42 protein signal transduction
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0043691 reverse cholesterol transport
Biological Process GO:0019433 triglyceride catabolic process
Biological Process GO:0070328 triglyceride homeostasis
Biological Process GO:0006641 triglyceride metabolic process
Biological Process GO:0034379 very-low-density lipoprotein particle assembly
molecular function GO:0015485 cholesterol binding
molecular function GO:0030234 enzyme regulator activity
molecular function GO:0070653 high-density lipoprotein particle receptor binding
molecular function GO:0055102 lipase inhibitor activity
molecular function GO:0005543 phospholipid binding
cellular component GO:0042627 chylomicron
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005769 early endosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0034363 intermediate-density lipoprotein particle
cellular component GO:0034366 spherical high-density lipoprotein particle
cellular component GO:0034361 very-low-density lipoprotein particle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-2187338 Visual phototransduction
R-HSA-2187338 Visual phototransduction
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-382551 Transport of small molecules
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-8963888 Chylomicron assembly
R-HSA-8963898 Plasma lipoprotein assembly
R-HSA-8963899 Plasma lipoprotein remodeling
R-HSA-8963901 Chylomicron remodeling
R-HSA-8964058 HDL remodeling
R-HSA-975634 Retinoid metabolism and transport
R-HSA-975634 Retinoid metabolism and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001144 BXGD000028 Acne Vulgaris Skin and Connective Tissue Diseases
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002962 BXGD000160 Angina Pectoris Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011269 BXGD000710 Dementia, Vascular Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0011609 BXGD000737 Drug Eruptions Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0016522 BXGD001067 Foramen Ovale, Patent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020474 BXGD001397 Hyperlipidemia, Familial Combined Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020476 BXGD001398 Hyperlipoproteinemias Nutritional and Metabolic Diseases
C0020479 BXGD001399 Hyperlipoproteinemia Type III Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020480 BXGD001400 Hyperlipoproteinemia Type IV Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021655 BXGD001508 Insulin Resistance Nutritional and Metabolic Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0023817 BXGD001706 Hyperlipoproteinemia Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032181 BXGD002332 Platelet Count measurement
C0032897 BXGD002378 Prader-Willi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039128 BXGD002794 Syphilis Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0079773 BXGD003100 Lymphoma, T-Cell, Cutaneous Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0086445 BXGD003285 Idiopathic Membranous Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202171 BXGD004077 Phosphatidylinositol measurement
C0202236 BXGD004086 Triglycerides measurement
C0206064 BXGD004150 Microvascular Angina Cardiovascular Diseases
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0221715 BXGD004468 Intestinal carcinoma Digestive System Diseases; Neoplasms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0263420 BXGD005303 Hyperkeratosis lenticularis perstans Skin and Connective Tissue Diseases
C0267953 BXGD005795 Necrosis of pancreas Digestive System Diseases
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0282577 BXGD006816 Congenital Disorders of Glycosylation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0333559 BXGD006960 Infarction, Lacunar Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0342335 BXGD007461 insulin resistance in diabetes Nutritional and Metabolic Diseases
C0342883 BXGD007574 Cholesteryl Ester Transfer Protein Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0344724 BXGD007701 Ostium secundum atrial septal defect Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0406537 BXGD008348 Morbilliform Drug Reaction Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0523465 BXGD009209 Serum albumin measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0542037 BXGD009269 Hypotriglyceridemia
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0596848 BXGD009647 lipoprotein disorder Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0702166 BXGD009912 Acne Skin and Connective Tissue Diseases
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0852036 BXGD010934 Pregnancy associated hypertension Female Urogenital Diseases and Pregnancy Complications; Cardiovascular Diseases
C0853085 BXGD010963 Decreased LDL cholesterol concentration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0854441 BXGD011020 Gastric mucosal lesion
C0856151 BXGD011095 Fat redistribution
C0856169 BXGD011096 Endothelial dysfunction
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C0948242 BXGD011519 Nuchal bleb, familial Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C1257763 BXGD011803 Overnutrition Nutritional and Metabolic Diseases
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1280433 BXGD012125 Lipoatrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1291447 BXGD012214 Deficiency of triacylglycerol lipase
C1300257 BXGD012273 Thanatophoric dysplasia, type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1392786 BXGD012978 Cognitive changes Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1704417 BXGD013557 Hyperlipoproteinemia Type IIb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1704429 BXGD013561 Hypoalphalipoproteinemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1858501 BXGD015800 Spinocerebellar Ataxia 12 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1867743 BXGD016470 Premature coronary artery atherosclerosis Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2609253 BXGD017172 Macrovascular disease
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2712907 BXGD017491 obsolete Combined hyperlipidemia
C2936179 BXGD018103 Obesity, Visceral Nutritional and Metabolic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3151467 BXGD018435 Apolipoprotein C-III Deficiency Nutritional and Metabolic Diseases
C3160761 BXGD018475 Diabetic dyslipidaemia
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3665335 BXGD019275 Cutis laxa, autosomal recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C3665365 BXGD019282 Arteriosclerotic cardiovascular disease, NOS Cardiovascular Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4015848 BXGD020236 APOLIPOPROTEIN C-III, NONGLYCOSYLATED PHENOTYPE
C4016282 BXGD020300 BREAST CANCER, SOMATIC
C4081731 BXGD022080 Hereditary systemic amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4476910 BXGD022887 Thin-cap fibroatheroma Cardiovascular Diseases
C4524040 BXGD023086 Atherogenic dyslipidaemia
C4529962 BXGD023178 Fatty Liver Disease
C4551591 BXGD023364 Increased HDL cholesterol concentration Nutritional and Metabolic Diseases
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein