Showing entry for Plasma kallikrein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006118
Protein NamePlasma kallikrein
Uniport IdP03952
GeneKLKB1
Gene Id3818
DomainPAN_1; Trypsin
Pfam PF00024   PF00089  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007597 blood coagulation, intrinsic pathway
Biological Process GO:0022617 extracellular matrix disassembly
Biological Process GO:0002542 Factor XII activation
Biological Process GO:0042730 fibrinolysis
Biological Process GO:0031639 plasminogen activation
Biological Process GO:0051919 positive regulation of fibrinolysis
Biological Process GO:0006508 proteolysis
Biological Process GO:0031638 zymogen activation
molecular function GO:0004252 serine-type endopeptidase activity
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade)
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1474244 Extracellular matrix organization
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-1643685 Disease
R-HSA-9651496 Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
R-HSA-9657688 Defective factor XII causes hereditary angioedema
R-HSA-9657689 Defective SERPING1 causes hereditary angioedema
R-HSA-9671793 Diseases of hemostasis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007274 BXGD000456 Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0014356 BXGD000910 Enterocolitis Digestive System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0019243 BXGD001308 Angioedemas, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C0020488 BXGD001402 Hypernatremia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025221 BXGD001837 Meleda Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030605 BXGD002248 Activated Partial Thromboplastin Time measurement
C0034065 BXGD002454 Pulmonary Embolism Respiratory Tract Diseases; Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0079153 BXGD003064 Hyperkeratosis, Epidermolytic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0087086 BXGD003320 Thrombus Cardiovascular Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0150988 BXGD003404 Sclerodactyly Skin and Connective Tissue Diseases
C0162701 BXGD003978 Polysomnography
C0201874 BXGD004054 Amino acids measurement
C0202202 BXGD004082 Protein measurement
C0240671 BXGD005048 Partial thromboplastin time increased (finding)
C0242129 BXGD005136 Thrombotic stroke Nervous System Diseases; Cardiovascular Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0265334 BXGD005520 Pachyonychia Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0272339 BXGD006350 Prekallikrein deficiency Hemic and Lymphatic Diseases
C0272340 BXGD006351 High molecular weight kininogen deficiency Hemic and Lymphatic Diseases
C0275524 BXGD006376 Coinfection Infections
C0311370 BXGD006882 Lupus anticoagulant disorder Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0337438 BXGD007159 Glucose measurement
C0432475 BXGD008794 XX males Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0495706 BXGD009038 elevated blood glucose level
C0523465 BXGD009209 Serum albumin measurement
C0523677 BXGD009215 Glycine measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524702 BXGD009242 Pulmonary Thromboembolisms Respiratory Tract Diseases; Cardiovascular Diseases
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0578870 BXGD009553 Chronic idiopathic urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596321 BXGD009642 Chemical Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0730285 BXGD009943 Diabetic macular edema Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0741237 BXGD010027 arthritis symptoms
C0742468 BXGD010063 Central nervous system lesion
C0744314 BXGD010091 Gastroenterocolitis
C0750988 BXGD010275 Common Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0750989 BXGD010276 External Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0750990 BXGD010277 Internal Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0883409 BXGD011395 Cardiac troponin I measurement
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611184 BXGD013455 Calcification of coronary artery Nutritional and Metabolic Diseases; Cardiovascular Diseases
C1721006 BXGD013700 Keratoderma, Palmoplantar, Epidermolytic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1859486 BXGD015901 BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2697764 BXGD017434 Interleukin 16 Measurement
C2939094 BXGD018171 Skin sensitisation
C2985280 BXGD018223 Blood Protein Measurement
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000989 Glutathione 307.32
BXGC0002682 Zinc 65.41
BXGC0003705 Chloride 35.45
BXGC0006368 Formic acid 46.03
BXGC0028981 Serine 105.04
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein