Showing entry for Keratin, type II cytoskeletal 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006176
Protein NameKeratin, type II cytoskeletal 1
Uniport IdP04264
GeneKRT1
Gene Id3848
DomainFilament; Keratin_2_head; Keratin_2_tail
Pfam PF00038   PF16208   PF16210  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001867 complement activation, lectin pathway
Biological Process GO:0070268 cornification
Biological Process GO:0061436 establishment of skin barrier
Biological Process GO:0042730 fibrinolysis
Biological Process GO:0031424 keratinization
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0018149 peptide cross-linking
Biological Process GO:0051290 protein heterotetramerization
Biological Process GO:0045765 regulation of angiogenesis
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0001895 retina homeostasis
molecular function GO:0030246 carbohydrate binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0038023 signaling receptor activity
molecular function GO:0030280 structural constituent of skin epidermis
cellular component GO:0072562 blood microparticle
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0001533 cornified envelope
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0045095 keratin filament
cellular component GO:0016020 membrane
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006079 BXGD000365 Bowen's Disease Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011606 BXGD000735 Exfoliative dermatitis Skin and Connective Tissue Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0022579 BXGD001558 Keratoderma Skin and Connective Tissue Diseases
C0022584 BXGD001559 Keratoderma, Palmoplantar, Diffuse Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0022595 BXGD001562 Keratosis Follicularis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0022596 BXGD001563 Palmoplantar Keratosis Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0023652 BXGD001691 Lichen Sclerosus et Atrophicus Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024266 BXGD001754 Lymphocytic Choriomeningitis Infections; Nervous System Diseases
C0026948 BXGD001952 Mycosis Fungoides Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0037277 BXGD002677 Skin Diseases, Genetic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0041834 BXGD002935 Erythema Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0041948 BXGD002939 Uremia Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0043037 BXGD003023 Common wart Neoplasms; Infections; Skin and Connective Tissue Diseases
C0079153 BXGD003064 Hyperkeratosis, Epidermolytic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0079298 BXGD003073 Epidermolysis Bullosa Simplex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0153014 BXGD003612 Non-arthropod borne lymphocytic choriomeningitis Infections; Nervous System Diseases
C0221260 BXGD004424 Dystrophia unguium Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0221270 BXGD004430 Acanthosis Pathological Conditions, Signs and Symptoms
C0232462 BXGD004542 Decrease in appetite Digestive System Diseases; Nervous System Diseases; Mental Disorders
C0235989 BXGD004801 Renal interstitial fibrosis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0237849 BXGD004849 Peeling of skin
C0263580 BXGD005328 Ichthyosis hystrix Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0265334 BXGD005520 Pachyonychia Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0334082 BXGD006987 NEVUS, EPIDERMAL (disorder) Neoplasms
C0343110 BXGD007602 Epidermolytic palmoplantar keratoderma of Vorner Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0349506 BXGD007912 Photosensitivity of skin Skin and Connective Tissue Diseases
C0432306 BXGD008770 Ichthyosis Bullosa of Siemens Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0432307 BXGD008771 Ichthyosis hystrix of Curth-Macklin
C0432316 BXGD008773 Epidermolysis bullosa simplex with mottled pigmentation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0521707 BXGD009166 Bilateral cataracts (disorder) Eye Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0853087 BXGD010964 Nail abnormality Pathological Conditions, Signs and Symptoms
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332271 BXGD012519 Perianal Squamous Intraepithelial Neoplasia
C1519346 BXGD013235 Skin Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1721006 BXGD013700 Keratoderma, Palmoplantar, Epidermolytic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1833030 BXGD013894 PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1835671 BXGD014041 Keratoderma palmoplantar spastic paralysis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Nervous System Diseases
C1836681 BXGD014147 Erythrokeratoderma, Reticular Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1838440 BXGD014315 ICHTHYOSIS EXFOLIATIVA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1840296 BXGD014442 Ichthyosis hystrix, Curth Macklin type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1843463 BXGD014584 Ichthyosis, Cyclic, with Epidermolytic Hyperkeratosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1845050 BXGD014703 PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1852289 BXGD015270 Autoamputation of digits Musculoskeletal Diseases
C1853193 BXGD015312 Recurrent skin infections Infections; Skin and Connective Tissue Diseases
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2132198 BXGD016930 Abnormal blistering of the skin
C2674218 BXGD017240 SPHEROCYTOSIS, TYPE 1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2931123 BXGD017962 Keratosis palmoplantaris striata 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C2931735 BXGD018054 Epidermolytic palmoplantar keratoderma Vorner type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2936837 BXGD018143 Keratosis of Greither Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C3665596 BXGD019295 Warts Infections; Skin and Connective Tissue Diseases
C3665704 BXGD019299 Congenital reticular ichthyosiform erythroderma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4016141 BXGD020279 ICHTHYOSIS HISTRIX, CURTH-MACKLIN TYPE
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4021849 BXGD020818 Conjunctival hamartoma
C4023143 BXGD021122 Bleeding with minor or no trauma
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4274414 BXGD022354 Epstein-Barr virus associated gastric carcinoma
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4707237 BXGD023710 Striate palmoplantar keratoderma Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4723838 BXGD023809 Metastatic Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein