Showing entry for Argininosuccinate lyase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006214
Protein NameArgininosuccinate lyase
Uniport IdP04424
GeneASL
Gene Id435
DomainASL_C2; Lyase_1
Pfam PF14698   PF00206  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00220 Arginine biosynthesis
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01230 Biosynthesis of amino acids
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0042450 arginine biosynthetic process via ornithine
Biological Process GO:0000050 urea cycle
molecular function GO:0004056 argininosuccinate lyase activity
molecular function GO:0042802 identical protein binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-70635 Urea cycle
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002064 BXGD000100 Alkalosis, Respiratory Nutritional and Metabolic Diseases; Respiratory Tract Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006114 BXGD000371 Cerebral Edema Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009421 BXGD000608 Comatose Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0023380 BXGD001640 Lethargy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027859 BXGD002052 Acoustic Neuroma Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0036221 BXGD002588 Mast-Cell Sarcoma Neoplasms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0151904 BXGD003501 Aspartate Aminotransferase Increased Digestive System Diseases
C0151945 BXGD003508 Thrombosis of cerebral veins Nervous System Diseases; Cardiovascular Diseases
C0154246 BXGD003709 Urea Cycle Disorders, Inborn Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220994 BXGD004357 Hyperammonemia Pathological Conditions, Signs and Symptoms
C0221505 BXGD004466 Lesion of brain
C0238621 BXGD004947 Aminoaciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242184 BXGD005140 Hypoxia Pathological Conditions, Signs and Symptoms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242706 BXGD005191 Hyperoxia Pathological Conditions, Signs and Symptoms
C0263485 BXGD005313 Clastothrix Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0263490 BXGD005314 Brittle hair
C0263746 BXGD005346 Osteoarthritis of the hand Musculoskeletal Diseases
C0267797 BXGD005777 Acute hepatitis Digestive System Diseases
C0268128 BXGD005828 Orotic aciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0268547 BXGD005979 Argininosuccinic Aciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268548 BXGD005980 Hyperargininemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0277960 BXGD006488 Dry hair
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280803 BXGD006766 Primary central nervous system lymphoma Neoplasms; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0349588 BXGD007933 Short stature
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0520459 BXGD009084 Necrotizing Enterocolitis Digestive System Diseases
C0557874 BXGD009444 Global developmental delay
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0751753 BXGD010576 Carbamoyl-Phosphate Synthase I Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0810364 BXGD010846 Cleft Lip with or without Cleft Palate
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1335713 BXGD012805 Recurrent Meningioma Neoplasms; Nervous System Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1839531 BXGD014381 Protein avoidance
C1839533 BXGD014383 Hyperglutaminemia
C1839541 BXGD014384 Episodic ammonia intoxication
C1839735 BXGD014398 MILES-CARPENTER X-LINKED MENTAL RETARDATION SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1855106 BXGD015459 Neonatal onset
C1997217 BXGD016859 Low grade glioma Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2674608 BXGD017250 Feeding difficulties in infancy
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2919142 BXGD017867 Short Stature, CTCAE
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4023397 BXGD021175 Abnormal hair quantity
C4025095 BXGD021556 Hypoargininemia
C4082171 BXGD022085 Hyperammonemia Due to Carbamoyl Phosphate Synthetase 1 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C4082937 BXGD022095 Necrotizing enterocolitis in fetus OR newborn Digestive System Diseases
C4085580 BXGD022117 Carbamoyl Phosphate Synthase 1 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C4552810 BXGD023525 Irritability, CTCAE
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001630 Arginine 174.2
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein