Showing entry for DNA topoisomerase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006505
Protein NameDNA topoisomerase 2
Uniport IdP06786
GeneTOP2
Gene Id855636
DomainDNA_gyraseB; DNA_topoisoIV; HATPase_c; Toprim; TOPRIM_C
Pfam PF00204   PF00521   PF02518   PF01751   PF16898  
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006333 chromatin assembly or disassembly
Biological Process GO:0031055 chromatin remodeling at centromere
Biological Process GO:0006271 DNA strand elongation involved in DNA replication
Biological Process GO:0006265 DNA topological change
Biological Process GO:0090202 gene looping
Biological Process GO:0044774 mitotic DNA integrity checkpoint
Biological Process GO:0007131 reciprocal meiotic recombination
Biological Process GO:0000019 regulation of mitotic recombination
Biological Process GO:0097046 replication fork progression beyond termination site
Biological Process GO:0000712 resolution of meiotic recombination intermediates
Biological Process GO:0009303 rRNA transcription
Biological Process GO:0000819 sister chromatid segregation
molecular function GO:0005524 ATP binding
molecular function GO:0003677 DNA binding
molecular function GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
cellular component GO:0097047 DNA replication termination region
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0000795 synaptonemal complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0024813 Demethoxycurcumin 338.12
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0049358 Bisdemethoxycurcumin 308.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein