Showing entry for Villin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006877
Protein NameVillin-1
Uniport IdP09327
GeneVIL1
Gene Id7429
DomainGelsolin; VHP
Pfam PF00626   PF02209  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051693 actin filament capping
Biological Process GO:0030042 actin filament depolymerization
Biological Process GO:0030041 actin filament polymerization
Biological Process GO:0051014 actin filament severing
Biological Process GO:0045010 actin nucleation
Biological Process GO:0008154 actin polymerization or depolymerization
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0035729 cellular response to hepatocyte growth factor stimulus
Biological Process GO:0060327 cytoplasmic actin-based contraction involved in cell motility
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0001951 intestinal D-glucose absorption
Biological Process GO:0032233 positive regulation of actin filament bundle assembly
Biological Process GO:0030836 positive regulation of actin filament depolymerization
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0010634 positive regulation of epithelial cell migration
Biological Process GO:2000394 positive regulation of lamellipodium morphogenesis
Biological Process GO:0040018 positive regulation of multicellular organism growth
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0051125 regulation of actin nucleation
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:2000392 regulation of lamellipodium morphogenesis
Biological Process GO:0032532 regulation of microvillus length
Biological Process GO:0061041 regulation of wound healing
Biological Process GO:0009617 response to bacterium
Biological Process GO:1902896 terminal web assembly
molecular function GO:0051015 actin filament binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
molecular function GO:0042802 identical protein binding
molecular function GO:0035727 lysophosphatidic acid binding
molecular function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0032432 actin filament bundle
cellular component GO:0005903 brush border
cellular component GO:0005737 cytoplasm
cellular component GO:0070062 extracellular exosome
cellular component GO:0030175 filopodium
cellular component GO:0032433 filopodium tip
cellular component GO:0030027 lamellipodium
cellular component GO:0005902 microvillus
cellular component GO:0005886 plasma membrane
cellular component GO:0001726 ruffle
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005890 BXGD000345 Body Height
C0007097 BXGD000424 Carcinoma Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0009326 BXGD000598 Collagen Diseases Skin and Connective Tissue Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010709 BXGD000689 Cyst Pathological Conditions, Signs and Symptoms; Neoplasms
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0017654 BXGD001136 Glomerular Filtration Rate
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0035435 BXGD002549 Rheumatism Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0202236 BXGD004086 Triglycerides measurement
C0267187 BXGD005736 Intestinal metaplasia of gastric mucosa Digestive System Diseases; Neoplasms
C0279672 BXGD006678 Cervical Adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0279674 BXGD006679 Small cell carcinoma of the cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334037 BXGD006980 Intestinal metaplasia
C0392885 BXGD008071 High density lipoprotein measurement
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0920646 BXGD011471 Ischemia of kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1265996 BXGD011927 Large cell neuroendocrine carcinoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714757 BXGD019430 Juvenile rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004275 Acetaldehyde 44.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein