Showing entry for Furin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006950
Protein NameFurin
Uniport IdP09958
GeneFURIN
Gene Id5045
DomainPeptidase_S8; P_proprotein; S8_pro-domain
Pfam PF01483   PF00082   PF16470  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001825 blastocyst formation
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0030574 collagen catabolic process
Biological Process GO:0070268 cornification
Biological Process GO:0090472 dibasic protein processing
Biological Process GO:0022617 extracellular matrix disassembly
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process
Biological Process GO:0032911 negative regulation of transforming growth factor beta1 production
Biological Process GO:0032455 nerve growth factor processing
Biological Process GO:0032902 nerve growth factor production
Biological Process GO:0043043 peptide biosynthetic process
Biological Process GO:0016486 peptide hormone processing
Biological Process GO:0051044 positive regulation of membrane protein ectodomain proteolysis
Biological Process GO:1901394 positive regulation of transforming growth factor beta1 activation
Biological Process GO:0016485 protein processing
Biological Process GO:0052548 regulation of endopeptidase activity
Biological Process GO:0051004 regulation of lipoprotein lipase activity
Biological Process GO:0045714 regulation of low-density lipoprotein particle receptor biosynthetic process
Biological Process GO:0042176 regulation of protein catabolic process
Biological Process GO:0009966 regulation of signal transduction
Biological Process GO:0032940 secretion by cell
Biological Process GO:0006465 signal peptide processing
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
Biological Process GO:0019058 viral life cycle
Biological Process GO:0019082 viral protein processing
Biological Process GO:0031638 zymogen activation
Biological Process GO:0097341 zymogen inhibition
molecular function GO:0004175 endopeptidase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0048406 nerve growth factor binding
molecular function GO:0008233 peptidase activity
molecular function GO:0042277 peptide binding
molecular function GO:0002020 protease binding
molecular function GO:0004252 serine-type endopeptidase activity
molecular function GO:0004867 serine-type endopeptidase inhibitor activity
cellular component GO:0009986 cell surface
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0010008 endosome membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005796 Golgi lumen
cellular component GO:0000139 Golgi membrane
cellular component GO:0030173 integral component of Golgi membrane
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0005886 plasma membrane
cellular component GO:0005802 trans-Golgi network
cellular component GO:0030140 trans-Golgi network transport vesicle
Reactome
Pathway Id Pathway Name
R-HSA-1181150 Signaling by NODAL
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1442490 Collagen degradation
R-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474244 Extracellular matrix organization
R-HSA-1566948 Elastic fibre formation
R-HSA-157118 Signaling by NOTCH
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
R-HSA-162582 Signal Transduction
R-HSA-162587 HIV Life Cycle
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-1643685 Disease
R-HSA-166520 Signaling by NTRKs
R-HSA-167060 NGF processing
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-171286 Synthesis and processing of ENV and VPU
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-175474 Assembly Of The HIV Virion
R-HSA-186797 Signaling by PDGF
R-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-382551 Transport of small molecules
R-HSA-392499 Metabolism of proteins
R-HSA-5210891 Uptake and function of anthrax toxins
R-HSA-5339562 Uptake and actions of bacterial toxins
R-HSA-5663205 Infectious disease
R-HSA-597592 Post-translational protein modification
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
R-HSA-8963899 Plasma lipoprotein remodeling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9036866 Expression and Processing of Neurotrophins
R-HSA-9658195 Leishmania infection
R-HSA-9662834 CD163 mediating an anti-inflammatory response
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694614 Attachment and Entry
R-HSA-977225 Amyloid fiber formation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0003128 BXGD000181 Anovulation Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005699 BXGD000325 Blast Phase Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008074 BXGD000519 Child Development Disorders, Pervasive Mental Disorders
C0008149 BXGD000520 Chlamydia Infections Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015674 BXGD001012 Chronic Fatigue Syndrome Infections; Musculoskeletal Diseases; Nervous System Diseases
C0016059 BXGD001043 Fibrosis Pathological Conditions, Signs and Symptoms
C0017638 BXGD001132 Glioma Neoplasms
C0018081 BXGD001171 Gonorrhea Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0018671 BXGD001211 Head and Neck Neoplasms Neoplasms
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0021775 BXGD001512 Intermittent Claudication Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024031 BXGD001727 Low Back Pain Pathological Conditions, Signs and Symptoms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024667 BXGD001794 Animal Mammary Neoplasms Neoplasms; Animal Diseases
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0086981 BXGD003317 Sicca Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0151449 BXGD003419 Primary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0259779 BXGD005218 Fibrous Dysplasia
C0428883 BXGD008639 Diastolic blood pressure
C0428886 BXGD008640 Mean blood pressure
C0429468 BXGD008651 Anovulatory (finding) Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0457950 BXGD008900 Acute low back pain Pathological Conditions, Signs and Symptoms
C0518948 BXGD009072 Chlamydia trachomatis infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0740340 BXGD009978 Amyloidosis, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0871470 BXGD011316 Systolic Pressure
C1257925 BXGD011814 Mammary Carcinoma, Animal Neoplasms; Animal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306620 BXGD012371 Systolic blood pressure measurement
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1842247 BXGD014508 CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1 Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2945695 BXGD018187 Limb ischemia
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C4025272 BXGD021615 Peripheral arterial stenosis
C4290046 BXGD022507 trachomatis
C4479344 BXGD022934 SCLEROSING CHOLANGITIS, NEONATAL
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0005771 Decanoic acid 172.26
BXGC0006368 Formic acid 46.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein