Showing entry for Dihydrofolate reductase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007239
Protein NameDihydrofolate reductase
Uniport IdP0ABQ4
GenefolA
Gene Id52075369;944790
DomainDHFR_1
Pfam PF00186  
OrganismEscherichia coli (strain K12)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046452 dihydrofolate metabolic process
Biological Process GO:0046655 folic acid metabolic process
Biological Process GO:0006545 glycine biosynthetic process
Biological Process GO:0006730 one-carbon metabolic process
Biological Process GO:0046677 response to antibiotic
Biological Process GO:0042493 response to drug
Biological Process GO:0031427 response to methotrexate
Biological Process GO:0046654 tetrahydrofolate biosynthetic process
molecular function GO:0004146 dihydrofolate reductase activity
molecular function GO:0051871 dihydrofolic acid binding
molecular function GO:0005542 folic acid binding
molecular function GO:0051870 methotrexate binding
molecular function GO:0070401 NADP+ binding
molecular function GO:0050661 NADP binding
molecular function GO:0070402 NADPH binding
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0004266 2-Propanol 60.1
BXGC0005881 Urea 60.06
BXGC0006368 Formic acid 46.03
BXGC0007530 Folic acid 441.4
BXGC0030557 2,4-diaminopyrimidine 110.06
BXGC0030612 tetraethylene glycol 194.12
BXGC0052047 Levoleucovorin 473.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein