Showing entry for Complement C4-A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007387
Protein NameComplement C4-A
Uniport IdP0C0L4
GeneC4A
Gene Id720;721
DomainA2M; A2M_BRD; A2M_recep; ANATO; MG2; MG3; MG4; NTR; TED_complement
Pfam PF00207   PF07703   PF07677   PF01821   PF01835   PF17791   PF17789   PF01759   PF07678  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05133 Pertussis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05133 Pertussis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0006956 complement activation
Biological Process GO:0006958 complement activation, classical pathway
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:2000427 positive regulation of apoptotic cell clearance
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0030449 regulation of complement activation
molecular function GO:0001849 complement component C1q complex binding
molecular function GO:0004866 endopeptidase inhibitor activity
cellular component GO:0030424 axon
cellular component GO:0072562 blood microparticle
cellular component GO:0030425 dendrite
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-166658 Complement cascade
R-HSA-166663 Initial triggering of complement
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-174577 Activation of C3 and C5
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-977606 Regulation of Complement cascade
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001627 BXGD000068 Congenital adrenal hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011609 BXGD000737 Drug Eruptions Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0019243 BXGD001308 Angioedemas, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033626 BXGD002412 Protein Deficiency Nutritional and Metabolic Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034150 BXGD002466 Purpura Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0035439 BXGD002551 Rheumatic Heart Disease Infections; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037116 BXGD002666 Silicosis Respiratory Tract Diseases; Occupational Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038644 BXGD002776 Sudden infant death syndrome Pathological Conditions, Signs and Symptoms
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0042165 BXGD002966 Anterior uveitis Eye Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0155765 BXGD003819 Disease of capillaries Cardiovascular Diseases
C0162538 BXGD003954 Immunoglobulin A deficiency (disorder) Immune System Diseases; Hemic and Lymphatic Diseases
C0221023 BXGD004369 Cyclic neutropenia Hemic and Lymphatic Diseases
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0268287 BXGD005884 Deficiency of steroid 21-monooxygenase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0272242 BXGD006330 Complement deficiency disease Immune System Diseases; Hemic and Lymphatic Diseases
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0342464 BXGD007482 Salt-losing congenital adrenal hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0395866 BXGD008170 Recurrent acute otitis media
C0406537 BXGD008348 Morbilliform Drug Reaction Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0409979 BXGD008402 Neonatal Systemic lupus erythematosus Skin and Connective Tissue Diseases; Immune System Diseases
C0520463 BXGD009085 Chronic active hepatitis Digestive System Diseases
C0701807 BXGD009901 Acute anterior uveitis Eye Diseases
C0730314 BXGD009955 Chronic central serous chorioretinopathy Pathological Conditions, Signs and Symptoms; Eye Diseases
C0730315 BXGD009956 Acute central serous chorioretinopathy Infections; Eye Diseases
C0852654 BXGD010947 21-hydroxylase deficiency
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C2936858 BXGD018147 Congenital adrenal hyperplasia due to 21 hydroxylase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3150275 BXGD018300 COMPLEMENT COMPONENT 2 DEFICIENCY
C3280641 BXGD018849 Decreased serum complement C4b
C3280642 BXGD018850 Complement Component 4a Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein