Showing entry for Replicase polyprotein 1a


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007435
Protein NameReplicase polyprotein 1a
Uniport IdP0C6U8
Gene1a
Gene Id
DomainCorona_NSP4_C; DUF3655; Macro; NAR; Nsp1; NSP10; Nsp3_PL2pro; nsp7; nsp8; nsp9; Peptidase_C30; SUD-M; Viral_protease
Pfam PF16348   PF12379   PF01661   PF16251   PF11501   PF09401   PF12124   PF08716   PF08717   PF08710   PF05409   PF11633   PF08715  
OrganismHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0039595 induction by virus of catabolism of host mRNA
Biological Process GO:0039520 induction by virus of host autophagy
Biological Process GO:0039519 modulation by virus of host autophagy
Biological Process GO:0039648 modulation by virus of host protein ubiquitination
Biological Process GO:0039690 positive stranded viral RNA replication
Biological Process GO:0016540 protein autoprocessing
Biological Process GO:0071108 protein K48-linked deubiquitination
Biological Process GO:0070536 protein K63-linked deubiquitination
Biological Process GO:0039548 suppression by virus of host IRF3 activity
Biological Process GO:0039579 suppression by virus of host ISG15 activity
Biological Process GO:0039644 suppression by virus of host NF-kappaB transcription factor activity
Biological Process GO:0039722 suppression by virus of host toll-like receptor signaling pathway
Biological Process GO:0039547 suppression by virus of host TRAF activity
Biological Process GO:0039604 suppression by virus of host translation
Biological Process GO:0039502 suppression by virus of host type I interferon-mediated signaling pathway
Biological Process GO:0039501 suppression by virus of host type I interferon production
Biological Process GO:0019079 viral genome replication
Biological Process GO:0019082 viral protein processing
Biological Process GO:0039694 viral RNA genome replication
Biological Process GO:0019083 viral transcription
molecular function GO:0004197 cysteine-type endopeptidase activity
molecular function GO:0003725 double-stranded RNA binding
molecular function GO:0004519 endonuclease activity
molecular function GO:0019785 ISG15-specific protease activity
molecular function GO:0046983 protein dimerization activity
molecular function GO:0003727 single-stranded RNA binding
molecular function GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
molecular function GO:0016740 transferase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0039714 cytoplasmic viral factory
cellular component GO:0030430 host cell cytoplasm
cellular component GO:0033644 host cell membrane
cellular component GO:0044220 host cell perinuclear region of cytoplasm
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-5663205 Infectious disease
R-HSA-9678108 SARS-CoV-1 Infection
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription
R-HSA-9682706 Replication of the SARS-CoV-1 genome
R-HSA-9682708 Transcription of SARS-CoV-1 sgRNAs
R-HSA-9683439 Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)
R-HSA-9684325 Maturation of replicase proteins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0002911 Fur-2-aldehyde 96.08
BXGC0002960 Thiophen-2-carboxyaldehyde 112.15
BXGC0003705 Chloride 35.45
BXGC0003817 Miltiorone 282.38
BXGC0005851 Angelicin 186.17
BXGC0005984 Psoralidin 336.34
BXGC0006213 Psoralen 186.17
BXGC0018374 Methyl Tanshinonate 338.12
BXGC0018607 Tanshinone Iib 310.12
BXGC0028425 Neobavaisoflavone 322.12
BXGC0037599 Tanshinone Iia 294.13
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0039940 bavachinin 338.15
BXGC0049929 Isobavachalcone 324.14
BXGC0050651 Cryptotanshinone 296.14
BXGC0052948 Tanshinone I 276.08
BXGC0053767 Dihydrotanshinone I 278.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein