Showing entry for Lysosomal alpha-glucosidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007550
Protein NameLysosomal alpha-glucosidase
Uniport IdP10253
GeneGAA
Gene Id2548
DomainGal_mutarotas_2; Glyco_hydro_31; NtCtMGAM_N; Trefoil
Pfam PF13802   PF01055   PF16863   PF00088  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00052 Galactose metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00500 Starch and sucrose metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0002086 diaphragm contraction
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0005980 glycogen catabolic process
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0007040 lysosome organization
Biological Process GO:0000023 maltose metabolic process
Biological Process GO:0046716 muscle cell cellular homeostasis
Biological Process GO:0050885 neuromuscular process controlling balance
Biological Process GO:0050884 neuromuscular process controlling posture
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0002026 regulation of the force of heart contraction
Biological Process GO:0005985 sucrose metabolic process
Biological Process GO:0009888 tissue development
Biological Process GO:0043181 vacuolar sequestering
molecular function GO:0004558 alpha-1,4-glucosidase activity
molecular function GO:0030246 carbohydrate binding
molecular function GO:0032450 maltose alpha-glucosidase activity
cellular component GO:0035577 azurophil granule membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0101003 ficolin-1-rich granule membrane
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005765 lysosomal membrane
cellular component GO:0005764 lysosome
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0070821 tertiary granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-3229121 Glycogen storage diseases
R-HSA-5357609 Glycogen storage disease type II (GAA)
R-HSA-5663084 Diseases of carbohydrate metabolism
R-HSA-5668914 Diseases of metabolism
R-HSA-6798695 Neutrophil degranulation
R-HSA-70221 Glycogen breakdown (glycogenolysis)
R-HSA-71387 Metabolism of carbohydrates
R-HSA-8982491 Glycogen metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002986 BXGD000165 Fabry Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0003486 BXGD000197 Aortic Aneurysm Cardiovascular Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016522 BXGD001067 Foramen Ovale, Patent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0016719 BXGD001074 Friedreich Ataxia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0017665 BXGD001141 Membranous glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0017919 BXGD001150 Glycogen Storage Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0017923 BXGD001154 Glycogen Storage Disease Type IV Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0024421 BXGD001770 Macroglossia Stomatognathic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035232 BXGD002517 Respiratory Paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0043202 BXGD003037 Wolff-Parkinson-White Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0086445 BXGD003285 Idiopathic Membranous Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0162670 BXGD003970 Mitochondrial Myopathies Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0221629 BXGD004467 Proximal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234958 BXGD004702 Muscle degeneration Musculoskeletal Diseases
C0238461 BXGD004936 Anaplastic thyroid carcinoma Neoplasms
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0242973 BXGD005202 Ventricular Dysfunction Cardiovascular Diseases
C0268237 BXGD005861 Cytochrome-c Oxidase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270984 BXGD006149 Metabolic myopathy Musculoskeletal Diseases; Nervous System Diseases
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0342751 BXGD007542 Generalized glycogen storage disease of infants Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0342753 BXGD007543 Glycogen storage disease due to acid maltase deficiency, late-onset Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0520878 BXGD009117 Shortened PR interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0751172 BXGD010335 Adult Glycogen Storage Disease Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751173 BXGD010336 Glycogen Storage Disease Type II, Infantile Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751174 BXGD010337 Glycogen Storage Disease Type II, Juvenile Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0917713 BXGD011404 Becker Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1704378 BXGD013554 Heymann Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C1850656 BXGD015167 Firm muscles
C1854301 BXGD015391 Motor delay Mental Disorders
C1856689 BXGD015630 FRIEDREICH ATAXIA 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1968741 BXGD016733 Glycogen Storage Disease IIIC Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1969443 BXGD016778 Trifunctional Protein Deficiency With Myopathy And Neuropathy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2985280 BXGD018223 Blood Protein Measurement
C3539168 BXGD019085 PEROXISOME BIOGENESIS DISORDER, COMPLEMENTATION GROUP A
C3806467 BXGD019513 Respiratory insufficiency due to muscle weakness Respiratory Tract Diseases
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C3888924 BXGD019993 Glycogen storage disease due to acid maltase deficiency, infantile onset Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C3888925 BXGD019994 Pompe's disease adult onset
C4016981 BXGD020394 GLYCOGEN STORAGE DISEASE II, ADULT FORM
C4021152 BXGD020565 Abnormal CNS myelination
C4476540 BXGD022824 Dilatation of the cerebral artery Nervous System Diseases; Cardiovascular Diseases
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4732730 BXGD023895 Blood spots
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000099 3,4-Dihydroxyphenylacetic acid 168.15
BXGC0000230 Ochratoxin A 403.81
BXGC0000324 Isovitexin 432.38
BXGC0000369 Methyl gallate 184.15
BXGC0000370 5-Hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-3-heptanone 328.4
BXGC0000392 Eriodictyol 288.26
BXGC0000430 Gossypol 518.55
BXGC0000436 Glycerol 92.09
BXGC0000484 2,4,5-Trimethoxybenzaldehyde 196.2
BXGC0000505 Protocatechuic acid 154.12
BXGC0000622 Nicotinic acid 123.11
BXGC0000681 Umbelliferone 162.14
BXGC0001079 Xanthoangelol 392.49
BXGC0001238 3-Methoxy-4-hydroxyphenylacetic acid 182.17
BXGC0001403 5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone 418.39
BXGC0001495 (R)-Roemerine 279.33
BXGC0001498 Boldine 327.37
BXGC0001544 Harmaline 214.26
BXGC0001644 Quercetin 3-glucosyl-(1->2)-galactosyl-(1->2)-glucoside 788.66
BXGC0001742 Eupafolin 316.26
BXGC0001747 Rosmarinic acid 360.31
BXGC0001765 (E)-Resveratrol 3-glucoside 390.39
BXGC0001767 (E)-Resveratrol 228.25
BXGC0001777 Schaftoside 564.49
BXGC0001789 Silibinin 482.44
BXGC0001800 (-)-Wikstromol 374.38
BXGC0001837 Quercetin 3-rutinoside 610.52
BXGC0001857 Caffeic acid 180.16
BXGC0001994 Hyperin 464.38
BXGC0002018 Morin 302.24
BXGC0002029 Taxifolin 304.25
BXGC0002052 Aesculetin 178.14
BXGC0002690 alpha-Catechin 290.27
BXGC0003066 Phenols 199.27
BXGC0003196 Aripiprazole 448.39
BXGC0003696 Quercetin 3-O-methyl-ether 316.26
BXGC0003705 Chloride 35.45
BXGC0003982 5-Hydroxyuracil 128.09
BXGC0004001 Benzyl 6-O-beta-D-apiofuranosyl-beta-D-glucoside 402.39
BXGC0004322 xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside 356.37
BXGC0004573 N-Acetylhistidine 197.19
BXGC0005049 4-Methylumbelliferyl acetate 218.21
BXGC0005502 Coumestrol 268.22
BXGC0005620 beta-D-Glucopyranose 180.16
BXGC0005625 alpha-D-Glucopyranose 180.16
BXGC0005683 Quercetin 302.24
BXGC0005793 Baicalein 270.24
BXGC0005945 2'-Hydroxygenistein 286.24
BXGC0005982 Curcumin 368.38
BXGC0006062 Isoorientin 448.38
BXGC0006073 Capsaicin 305.41
BXGC0006193 Ellagic acid 302.19
BXGC0006291 Scopoletin 192.17
BXGC0006308 Myricetin 3-rhamnoside 464.38
BXGC0006326 Imperatorin 270.28
BXGC0006635 Luteolin 286.24
BXGC0007052 Olomoucine 298.34
BXGC0007162 N-Methyl-1-deoxynojirimycin 177.2
BXGC0007530 Folic acid 441.4
BXGC0007559 gamma-Mangostin 396.43
BXGC0007560 alpha-Mangostin 410.46
BXGC0008184 Phloretin 274.27
BXGC0008753 Isoquercitrin 464.38
BXGC0008912 Panasenoside 610.52
BXGC0008943 Kaempferol 3-robinobioside 594.52
BXGC0009194 Quercetin 3-glucuronide 478.36
BXGC0009196 Quercetin 4'-glucoside 464.38
BXGC0009984 Pyrafoline D 347.45
BXGC0009993 (R)-Mahanine 347.45
BXGC0010605 N-Malonylanthranilic acid 223.18
BXGC0011280 Isothymonin 360.31
BXGC0011390 Dihydroroseoside 388.45
BXGC0011421 3-Hydroxy-1-(4-hydroxyphenyl)-1-propanone 166.17
BXGC0011901 Benzyl beta-primeveroside 402.39
BXGC0012236 Quercetin 3-alpha-D-galactoside 464.38
BXGC0013692 Hydroxychavicol 150.07
BXGC0014086 Vicenin-2 594.16
BXGC0014296 Bendazol 208.1
BXGC0014335 (7R,8S)-dihydrodehydrodiconiferyl alcohol 9-O-beta-D-glucopyranoside 522.21
BXGC0016028 Castanospermine 189.1
BXGC0016421 punicalin 782.06
BXGC0016470 Camptothecin 348.11
BXGC0017516 3-(3,4-Dimethoxyphenyl)Propan-1-Ol 196.11
BXGC0017596 Jatrorrhizine 338.14
BXGC0017701 Altenusin 290.08
BXGC0017933 Sulfuretin 270.05
BXGC0018397 beta-1,4-mannan 180.06
BXGC0018618 3-(1H-Indol-3-Yl)-2-(Trimethylazaniumyl)Propanoate 246.14
BXGC0019318 2-(Hydroxymethyl)Piperidine-3,4,5-Triol;Hydrochloride 163.08
BXGC0019538 benzyl glucopyranoside 270.11
BXGC0019578 callyspongynic acid 470.28
BXGC0021716 (R)-Verapamil 454.28
BXGC0021836 Honokiol 266.13
BXGC0022039 N-Methyl-1-Deoxynojirimycin 177.1
BXGC0022806 1-(5-Thiophen-2-Ylthiophen-2-Yl)Ethanone 208
BXGC0023321 Quercetin Dihydrate 302.04
BXGC0023497 Pterostilbene 256.11
BXGC0024132 1H-Indol-5-Ol 133.05
BXGC0025009 vanilloylcalleryanin 452.13
BXGC0025050 Diethyl 2,6-Dimethyl-4-Phenylpyridine-3,5-Dicarboxylate 327.15
BXGC0025485 Transtorine 189.04
BXGC0025757 Calcimycin 523.27
BXGC0026407 3,3-Dihydroxyterphenyllin 370.11
BXGC0026480 Osajin 404.16
BXGC0028589 5,6,7,8-Tetrahydroxy-2-(4-Hydroxyphenyl)Chromen-4-One 302.04
BXGC0028778 Fangchinoline 608.29
BXGC0029261 tachioside 302.1
BXGC0029667 icariside B5 388.21
BXGC0029684 Cochinchinone A 448.22
BXGC0030236 Deoxymannojirimycin 163.08
BXGC0030304 4,4'-((1S,3Ar,4S,6Ar)-Hexahydrofuro[3,4-C]Furan-1,4-Diyl)Bis(2-Methoxyphenol) 358.14
BXGC0030739 ISOPROPYL BETA-D-GLUCOPYRANOSIDE 222.11
BXGC0031057 Butyl beta-D-glucopyranoside 236.13
BXGC0031109 2-Prop-1-En-2-Yl-2,3-Dihydrofuro[3,2-G]Chromen-7-One 228.08
BXGC0032319 L-Ido-1-Deoxynojirimycin 163.08
BXGC0033112 Acetylcysteine 163.03
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0033407 4''-Deoxyterphenyllin 322.12
BXGC0034712 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-Trihydroxy-2,3-Dihydrochromen-4-One 304.06
BXGC0034968 Dienestrol 266.13
BXGC0034992 Orsellinic Acid 168.04
BXGC0036329 3-Hydroxyterphenyllin 354.11
BXGC0036632 Austrobailignan 6 328.17
BXGC0036805 Butylated Hydroxyanisole 180.12
BXGC0038577 Magnolol 266.13
BXGC0038769 Isovitexin 432.11
BXGC0039281 Methyl (1S,4As,5As,6R,10As)-1-Methyl-2'-Oxospiro[1,4A,5,5A,7,8,10,10A-Octahydropyrano[3,4-F]Indolizine-6,3'-1H-Indole]-4-Carboxylate 368.17
BXGC0039480 (1R,2R,3R,7S,8R)-3-(Hydroxymethyl)-2,3,5,6,7,8-Hexahydro-1H-Pyrrolizine-1,2,7-Triol 189.1
BXGC0039534 Orcinol 124.05
BXGC0039586 Prenylterphenyllin 406.18
BXGC0039670 Nodakenin 408.14
BXGC0040743 n.a 354.15
BXGC0040936 Sid26657808 284.07
BXGC0041132 Duvoglustat 163.08
BXGC0042240 3-(Furan-3-Yl)-3A,7-Dimethyl-3,4,5,6-Tetrahydro-2-Benzofuran-1-One 232.11
BXGC0042256 1,4-Bis[[(E)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoyl]Oxy]-3,5-Dihydroxycyclohexane-1-Carboxylic Acid 516.13
BXGC0042738 Columbianetin 246.09
BXGC0043172 1,3,7-Trihydroxy-2,4-Diisoprenylxanthone 380.16
BXGC0044200 Menadione 172.05
BXGC0044518 7-Geranyloxy-1,3-dihydroxyxanthone 380.16
BXGC0045389 n.a 360.14
BXGC0045390 n.a 410.22
BXGC0045391 n.a 410.22
BXGC0047088 Ursolic Acid 456.36
BXGC0047169 Hymecromone 176.05
BXGC0048313 Rosmarinic Acid 360.08
BXGC0048379 camptothecin 348.11
BXGC0048576 callyberyne C 276.19
BXGC0050184 Myricitrin 464.1
BXGC0050194 alpha-D-Mannose 180.06
BXGC0050422 n.a 193.1
BXGC0050608 Fagomine 147.09
BXGC0050823 Chebulinic acid 956.11
BXGC0050877 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-Dihydro-2H-Chromene-3,5,7-Triol;Hydrate 290.08
BXGC0052229 Marein 450.12
BXGC0052566 Sid22414536 180.04
BXGC0052593 Terphenyllin 338.12
BXGC0052755 Mitorubrinol 398.1
BXGC0053810 MEGxp0_001429 474.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein