Showing entry for Lysosomal protective protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007589
Protein NameLysosomal protective protein
Uniport IdP10619
GeneCTSA
Gene Id5476
DomainPeptidase_S10
Pfam PF00450  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
5. Organismal Systems 5.2 Endocrine system hsa04614 Renin-angiotensin system
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006687 glycosphingolipid metabolic process
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:1904715 negative regulation of chaperone-mediated autophagy
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0006508 proteolysis
Biological Process GO:1904714 regulation of chaperone-mediated autophagy
Biological Process GO:0031647 regulation of protein stability
molecular function GO:0004180 carboxypeptidase activity
molecular function GO:0008047 enzyme activator activity
molecular function GO:0004185 serine-type carboxypeptidase activity
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005764 lysosome
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-2132295 MHC class II antigen presentation
R-HSA-3781865 Diseases of glycosylation
R-HSA-392499 Metabolism of proteins
R-HSA-4085001 Sialic acid metabolism
R-HSA-428157 Sphingolipid metabolism
R-HSA-4341670 Defective NEU1 causes sialidosis
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
R-HSA-556833 Metabolism of lipids
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis
R-HSA-5668914 Diseases of metabolism
R-HSA-597592 Post-translational protein modification
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002986 BXGD000165 Fabry Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0003486 BXGD000197 Aortic Aneurysm Cardiovascular Diseases
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010036 BXGD000642 Corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0010038 BXGD000643 Corneal Opacity Eye Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013371 BXGD000823 Shigella Infections Digestive System Diseases; Infections
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017160 BXGD001099 Gastroenteritis Digestive System Diseases
C0018916 BXGD001245 Hemangioma Neoplasms
C0019342 BXGD001322 Genital Herpes Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026697 BXGD001918 Mucolipidoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042782 BXGD003001 Visceromegaly Pathological Conditions, Signs and Symptoms
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085131 BXGD003129 Gangliosidosis GM1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0086795 BXGD003311 Pfaundler-Hurler Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0154934 BXGD003757 Peripheral anterior synechiae
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0206638 BXGD004203 Giant Cell Tumor of Bone Neoplasms
C0239105 BXGD004962 Conjunctival telangiectasis
C0242172 BXGD005138 Pelvic Inflammatory Disease Female Urogenital Diseases and Pregnancy Complications; Infections
C0265482 BXGD005536 Ring Chromosome 20 Syndrome Pathological Conditions, Signs and Symptoms
C0267971 BXGD005798 Storage disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268226 BXGD005858 Type I Mucolipidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0268228 BXGD005859 Neuraminidase 1 deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0268233 BXGD005860 GALACTOSIALIDOSIS Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0278601 BXGD006547 Inflammatory Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0340629 BXGD007354 Aortic aneurysm without mention of rupture NOS Cardiovascular Diseases
C0349588 BXGD007933 Short stature
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0423250 BXGD008476 Corneal stromal opacities Eye Diseases
C0455988 BXGD008860 Hydrops Fetalis, Non-Immune Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0751587 BXGD010513 CADASIL Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1527349 BXGD013277 Ductal Breast Carcinoma Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1834129 BXGD013957 Abnormal vertebral morphology
C1838577 BXGD014321 Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1856559 BXGD015616 Decreased beta-galactosidase activity
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2216370 BXGD016949 Cherry red spot of the macula
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2718068 BXGD017524 beta-Galactosidase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2733158 BXGD017562 Cerebral Small Vessel Diseases Nervous System Diseases; Cardiovascular Diseases
C3665444 BXGD019288 Neutrophilia (disorder) Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C3711381 BXGD019387 Hereditary Diffuse Leukoencephalopathy with Spheroids Nervous System Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4017292 BXGD020431 GALACTOSIALIDOSIS, LATE INFANTILE
C4017293 BXGD020432 GALACTOSIALIDOSIS, ADULT
C4017294 BXGD020433 GALACTOSIALIDOSIS, EARLY INFANTILE
C4021536 BXGD020659 Mild conductive hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0018397 beta-1,4-mannan 180.06
BXGC0049447 acetate 59.01
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein