Showing entry for C-1-tetrahydrofolate synthase, cytoplasmic


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007723
Protein NameC-1-tetrahydrofolate synthase, cytoplasmic
Uniport IdP11586
GeneMTHFD1
Gene Id4522
DomainFTHFS; THF_DHG_CYH; THF_DHG_CYH_C
Pfam PF01268   PF00763   PF02882  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00670 One carbon pool by folate
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009257 10-formyltetrahydrofolate biosynthetic process
Biological Process GO:0048702 embryonic neurocranium morphogenesis
Biological Process GO:0048703 embryonic viscerocranium morphogenesis
Biological Process GO:0046655 folic acid metabolic process
Biological Process GO:0007507 heart development
Biological Process GO:0000105 histidine biosynthetic process
Biological Process GO:0009086 methionine biosynthetic process
Biological Process GO:0006555 methionine metabolic process
Biological Process GO:0001843 neural tube closure
Biological Process GO:0006730 one-carbon metabolic process
Biological Process GO:0006164 purine nucleotide biosynthetic process
Biological Process GO:0009070 serine family amino acid biosynthetic process
Biological Process GO:0009069 serine family amino acid metabolic process
Biological Process GO:0061053 somite development
Biological Process GO:0035999 tetrahydrofolate interconversion
molecular function GO:0005524 ATP binding
molecular function GO:0004329 formate-tetrahydrofolate ligase activity
molecular function GO:0004477 methenyltetrahydrofolate cyclohydrolase activity
molecular function GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity
molecular function GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0005739 mitochondrion
molecular function GO:0004486 methylenetetrahydrofolate dehydrogenase NAD(P)+ activity
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-196757 Metabolism of folate and pterines
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000832 BXGD000013 Abruptio Placentae Female Urogenital Diseases and Pregnancy Complications
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002888 BXGD000145 Anemia, Megaloblastic Hemic and Lymphatic Diseases
C0002902 BXGD000154 Anencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0004093 BXGD000251 Asthenia Pathological Conditions, Signs and Symptoms
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008412 BXGD000538 Choline Deficiency Nutritional and Metabolic Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011999 BXGD000770 Diastematomyelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016412 BXGD001058 Folic Acid Deficiency Nutritional and Metabolic Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023980 BXGD001725 Longevity
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0025312 BXGD001861 Meningomyelocele Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027806 BXGD002039 Neurenteric Cyst Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027902 BXGD002058 Neuropsychological Tests
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0080178 BXGD003107 Spina Bifida Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0080218 BXGD003109 Tethered Cord Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0152234 BXGD003566 Iniencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0152426 BXGD003589 Craniorachischisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0154723 BXGD003737 Migraine with Aura Nervous System Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0158646 BXGD003897 Cleft palate with cleft lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0200635 BXGD004041 Lymphocyte Count measurement
C0206368 BXGD004176 Exfoliation Syndrome Eye Diseases
C0220810 BXGD004346 Congenital defects
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266453 BXGD005671 Exencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0338480 BXGD007186 Common Migraine Nervous System Diseases
C0340288 BXGD007316 Stable angina Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0344479 BXGD007677 Spinal Cord Myelodysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0494261 BXGD009023 Combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0543641 BXGD009287 Megaloblastic anemia, secondary Hemic and Lymphatic Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0694550 BXGD009852 Recurrent pneumonia Infections; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0702169 BXGD009914 Acrania Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0741682 BXGD010039 Premenopausal breast cancer
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0810364 BXGD010846 Cleft Lip with or without Cleft Palate
C0836924 BXGD010864 Thrombocytosis Hemic and Lymphatic Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1291575 BXGD012220 Deficiency of citrate(si)-synthase
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1692886 BXGD013495 Arthritis, Bacterial Infections; Musculoskeletal Diseases
C1737329 BXGD013728 Dysmorphism Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1853238 BXGD015320 Conotruncal defect
C1866558 BXGD016409 Neural tube defect, folate-sensitive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1960883 BXGD016670 Spina bifida aperta of cervical spine Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4021736 BXGD020744 Decreased methylcobalamin
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4024948 BXGD021495 Anterior encephalocele
C4048270 BXGD021897 Decreased antibody level in blood
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4540434 BXGD023258 COMBINED IMMUNODEFICIENCY AND MEGALOBLASTIC ANEMIA WITH OR WITHOUT HYPERHOMOCYSTEINEMIA
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein