protein

Showing entry for Cholesteryl ester transfer protein

General Target Information
BXGT Id	BXGT007727
Protein Name	Cholesteryl ester transfer protein
Uniport Id	P11597
Gene	CETP
Gene Id	1071
Domain	LBP_BPI_CETP; LBP_BPI_CETP_C
Pfam	PF01273 PF02886
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
5. Organismal Systems	5.4 Digestive system	hsa04979	Cholesterol metabolism

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0042632	cholesterol homeostasis
Biological Process	GO:0008203	cholesterol metabolic process
Biological Process	GO:0030301	cholesterol transport
Biological Process	GO:0034375	high-density lipoprotein particle remodeling
Biological Process	GO:0055088	lipid homeostasis
Biological Process	GO:0006869	lipid transport
Biological Process	GO:0034374	low-density lipoprotein particle remodeling
Biological Process	GO:0010745	negative regulation of macrophage derived foam cell differentiation
Biological Process	GO:0046470	phosphatidylcholine metabolic process
Biological Process	GO:0055091	phospholipid homeostasis
Biological Process	GO:0032376	positive regulation of cholesterol transport
Biological Process	GO:2001140	positive regulation of phospholipid transport
Biological Process	GO:0010874	regulation of cholesterol efflux
Biological Process	GO:0043691	reverse cholesterol transport
Biological Process	GO:0070328	triglyceride homeostasis
Biological Process	GO:0006641	triglyceride metabolic process
Biological Process	GO:0034197	triglyceride transport
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling
molecular function	GO:0015485	cholesterol binding
molecular function	GO:0120020	cholesterol transfer activity
molecular function	GO:0008289	lipid binding
molecular function	GO:0031210	phosphatidylcholine binding
molecular function	GO:0005548	phospholipid transporter activity
molecular function	GO:0017129	triglyceride binding
cellular component	GO:0070062	extracellular exosome
cellular component	GO:0005576	extracellular region
cellular component	GO:0005615	extracellular space
cellular component	GO:0034364	high-density lipoprotein particle
cellular component	GO:0031982	vesicle

Reactome

Pathway Id	Pathway Name
R-HSA-162582	Signal Transduction
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-382551	Transport of small molecules
R-HSA-8963899	Plasma lipoprotein remodeling
R-HSA-8964041	LDL remodeling
R-HSA-8964058	HDL remodeling
R-HSA-9006931	Signaling by Nuclear Receptors
R-HSA-9024446	NR1H2 and NR1H3-mediated signaling
R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001622	BXGD000065	Adrenal Gland Hyperfunction	Endocrine System Diseases
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002622	BXGD000119	Amnesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0002873	BXGD000133	Anemia of chronic disease	Hemic and Lymphatic Diseases
C0002962	BXGD000160	Angina Pectoris	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0004096	BXGD000252	Asthma	Respiratory Tract Diseases; Immune System Diseases
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005890	BXGD000345	Body Height
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0007820	BXGD000491	Cerebrovascular Disorders	Nervous System Diseases; Cardiovascular Diseases
C0008350	BXGD000531	Cholelithiasis	Digestive System Diseases
C0008354	BXGD000533	Cholera	Infections
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0010054	BXGD000647	Coronary Arteriosclerosis	Cardiovascular Diseases
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0010481	BXGD000673	Cushing Syndrome	Endocrine System Diseases
C0011265	BXGD000708	Presenile dementia	Nervous System Diseases; Mental Disorders
C0011269	BXGD000710	Dementia, Vascular	Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881	BXGD000760	Diabetic Nephropathy	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0015695	BXGD001013	Fatty Liver	Digestive System Diseases
C0016977	BXGD001086	Gall Bladder Diseases	Digestive System Diseases
C0017921	BXGD001152	Glycogen storage disease type II	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018801	BXGD001226	Heart failure	Cardiovascular Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0019158	BXGD001293	Hepatitis	Digestive System Diseases
C0019829	BXGD001350	Hodgkin Disease	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020179	BXGD001363	Huntington Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020428	BXGD001377	Hyperaldosteronism	Endocrine System Diseases
C0020443	BXGD001385	Hypercholesterolemia	Nutritional and Metabolic Diseases
C0020445	BXGD001386	Hypercholesterolemia, Familial	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020459	BXGD001394	Hyperinsulinism	Nutritional and Metabolic Diseases
C0020473	BXGD001396	Hyperlipidemia	Nutritional and Metabolic Diseases
C0020474	BXGD001397	Hyperlipidemia, Familial Combined	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020476	BXGD001398	Hyperlipoproteinemias	Nutritional and Metabolic Diseases
C0020479	BXGD001399	Hyperlipoproteinemia Type III	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020550	BXGD001429	Hyperthyroidism	Endocrine System Diseases
C0020557	BXGD001432	Hypertriglyceridemia	Nutritional and Metabolic Diseases
C0020676	BXGD001462	Hypothyroidism	Endocrine System Diseases
C0022658	BXGD001570	Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660	BXGD001571	Kidney Failure, Acute	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023817	BXGD001706	Hyperlipoproteinemia Type I	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0024141	BXGD001740	Lupus Erythematosus, Systemic	Skin and Connective Tissue Diseases; Immune System Diseases
C0024299	BXGD001758	Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0027051	BXGD001963	Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027726	BXGD002030	Nephrotic Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028860	BXGD002093	Oculocerebrorenal Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0035309	BXGD002530	Retinal Diseases	Eye Diseases
C0035344	BXGD002541	Retinopathy of Prematurity	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036323	BXGD002595	Schistosomiasis	Infections
C0036690	BXGD002632	Septicemia	Pathological Conditions, Signs and Symptoms; Infections
C0038454	BXGD002760	Cerebrovascular accident	Nervous System Diseases; Cardiovascular Diseases
C0042373	BXGD002978	Vascular Diseases	Cardiovascular Diseases
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151744	BXGD003469	Myocardial Ischemia	Cardiovascular Diseases
C0153452	BXGD003647	Malignant neoplasm of gallbladder	Digestive System Diseases; Neoplasms
C0155626	BXGD003806	Acute myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0155733	BXGD003815	Atherosclerosis of aorta	Cardiovascular Diseases
C0155765	BXGD003819	Disease of capillaries	Cardiovascular Diseases
C0162871	BXGD003996	Aortic Aneurysm, Abdominal	Cardiovascular Diseases
C0201657	BXGD004051	C-reactive protein measurement
C0201950	BXGD004059	Cholesterol measurement test
C0202117	BXGD004074	Low density lipoprotein cholesterol measurement
C0202236	BXGD004086	Triglycerides measurement
C0234985	BXGD004708	Mental deterioration	Mental Disorders
C0235782	BXGD004769	Gallbladder Carcinoma	Digestive System Diseases; Neoplasms
C0242231	BXGD005144	Coronary Stenosis	Cardiovascular Diseases
C0242339	BXGD005150	Dyslipidemias	Nutritional and Metabolic Diseases
C0242383	BXGD005160	Age related macular degeneration	Eye Diseases
C0243026	BXGD005210	Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C0263420	BXGD005303	Hyperkeratosis lenticularis perstans	Skin and Connective Tissue Diseases
C0268601	BXGD006002	HMG CoA lyase deficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0271084	BXGD006159	Exudative age-related macular degeneration	Eye Diseases
C0271650	BXGD006227	Impaired glucose tolerance	Nutritional and Metabolic Diseases
C0271738	BXGD006253	Hypocortisolism secondary to another disorder	Endocrine System Diseases
C0302314	BXGD006837	Xanthoma	Nutritional and Metabolic Diseases
C0333463	BXGD006954	Senile Plaques	Pathological Conditions, Signs and Symptoms
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0339467	BXGD007248	Proliferative retinopathy	Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0342257	BXGD007447	Complications of Diabetes Mellitus	Endocrine System Diseases
C0342388	BXGD007473	Adrenocorticotropic hormone (ACTH) deficiency (disorder)	Endocrine System Diseases
C0342879	BXGD007570	Primary hypercholesterolemia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0342882	BXGD007573	Familial hypercholesterolemia - heterozygous	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0342883	BXGD007574	Cholesteryl Ester Transfer Protein Deficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0342890	BXGD007578	Primary combined hyperlipidemia
C0362046	BXGD007959	Prediabetes syndrome	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0392885	BXGD008071	High density lipoprotein measurement
C0400966	BXGD008266	Non-alcoholic Fatty Liver Disease	Digestive System Diseases
C0424295	BXGD008524	Hyperactive behavior	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428472	BXGD008630	Serum HDL cholesterol measurement
C0428474	BXGD008631	Serum LDL cholesterol measurement
C0473527	BXGD008939	Hypoalphalipoproteinemias	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0494463	BXGD009029	Alzheimer Disease, Late Onset	Nervous System Diseases; Mental Disorders
C0497327	BXGD009061	Dementia	Nervous System Diseases; Mental Disorders
C0523465	BXGD009209	Serum albumin measurement
C0523744	BXGD009217	Lipids measurement
C0524620	BXGD009236	Metabolic Syndrome X	Nutritional and Metabolic Diseases
C0524851	BXGD009246	Neurodegenerative Disorders	Nervous System Diseases
C0542037	BXGD009269	Hypotriglyceridemia
C0577631	BXGD009535	Carotid Atherosclerosis	Nervous System Diseases; Cardiovascular Diseases
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0598784	BXGD009670	Dyslipoproteinemias	Nutritional and Metabolic Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0742343	BXGD010061	Acute Chest Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0745103	BXGD010114	Hyperlipoproteinemia Type IIa	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0750952	BXGD010263	Biliary Tract Cancer	Digestive System Diseases; Neoplasms
C0751295	BXGD010383	Memory Loss	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0852949	BXGD010957	Arteriopathic disease	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0856169	BXGD011096	Endothelial dysfunction
C0856727	BXGD011108	Cholesterol gallstones	Digestive System Diseases
C0856737	BXGD011109	Single vessel disease	Cardiovascular Diseases
C0856738	BXGD011110	Triple vessel disease	Cardiovascular Diseases
C0857175	BXGD011140	Postinfarction
C0878521	BXGD011367	Beta thalassemia trait	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0947622	BXGD011493	Cholecystolithiasis	Digestive System Diseases
C0948008	BXGD011499	Ischemic stroke	Nervous System Diseases; Cardiovascular Diseases
C0948089	BXGD011504	Acute Coronary Syndrome	Cardiovascular Diseases
C0948242	BXGD011519	Nuchal bleb, familial	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0948387	BXGD011535	Secondary Adrenal Insufficiency	Endocrine System Diseases
C0948480	BXGD011540	Coronary Restenosis	Cardiovascular Diseases
C1096293	BXGD011616	Macroangiopathy
C1168443	BXGD011794	Pseudocholinesterase Measurement
C1275685	BXGD012092	Avellino corneal dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1299433	BXGD012258	Left main coronary artery disease	Cardiovascular Diseases
C1332206	BXGD012504	Adult Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979	BXGD012571	Childhood Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1337013	BXGD012876	Differentiated Thyroid Gland Carcinoma
C1392786	BXGD012978	Cognitive changes	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1445957	BXGD013081	Serum total cholesterol measurement
C1504336	BXGD013137	Polypoidal choroidal vasculopathy
C1536085	BXGD013334	Geographic Atrophy	Eye Diseases
C1561643	BXGD013363	Chronic Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1563937	BXGD013397	Atherogenesis	Cardiovascular Diseases
C1611743	BXGD013456	Familial (FPAH)
C1704417	BXGD013557	Hyperlipoproteinemia Type IIb	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1704429	BXGD013561	Hypoalphalipoproteinemia, Familial	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1706412	BXGD013572	Lipidemias	Nutritional and Metabolic Diseases
C1861172	BXGD016016	Venous Thromboembolism	Cardiovascular Diseases
C1867743	BXGD016470	Premature coronary artery atherosclerosis	Cardiovascular Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C1963943	BXGD016706	Atherothrombosis
C1963961	BXGD016708	Testosterone deficiency
C2047520	BXGD016891	Mixed hyperlipidemia (disorder)	Nutritional and Metabolic Diseases
C2237660	BXGD016962	exudative macular degeneration	Eye Diseases
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2362324	BXGD017091	Pediatric Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C2936179	BXGD018103	Obesity, Visceral	Nutritional and Metabolic Diseases
C2938924	BXGD018167	Oestrogen receptor positive breast cancer
C3149462	BXGD018280	HYPERALPHALIPOPROTEINEMIA 1
C3151466	BXGD018434	HEPATIC LIPASE DEFICIENCY (disorder)	Nutritional and Metabolic Diseases
C3160761	BXGD018475	Diabetic dyslipidaemia
C3241937	BXGD018578	Nonalcoholic Steatohepatitis	Digestive System Diseases
C3266262	BXGD018600	Multiple Chronic Conditions	Pathological Conditions, Signs and Symptoms
C3665365	BXGD019282	Arteriosclerotic cardiovascular disease, NOS	Cardiovascular Diseases
C3714619	BXGD019418	Insulin resistance syndrome	Nutritional and Metabolic Diseases
C3875011	BXGD019870	Familial hyperalphalipoproteinemia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4048329	BXGD021904	Immunosuppression
C4049446	BXGD021933	Neointimal hyperplasia
C4050214	BXGD021959	Cholesteryl Ester Transfer Protein Measurement
C4290140	BXGD022508	recurrent myocardial infarction
C4317171	BXGD022735	Adolescent Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4521075	BXGD023056	Childhood Overweight	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4524040	BXGD023086	Atherogenic dyslipidaemia
C4525297	BXGD023131	Stage 0 Gallbladder Cancer AJCC v8
C4525300	BXGD023132	Stage IIA Gallbladder Cancer AJCC v8
C4525301	BXGD023133	Stage IIB Gallbladder Cancer AJCC v8
C4525302	BXGD023134	Stage III Gallbladder Cancer AJCC v8
C4525305	BXGD023135	Stage IV Gallbladder Cancer AJCC v8
C4529962	BXGD023178	Fatty Liver Disease
C4551591	BXGD023364	Increased HDL cholesterol concentration	Nutritional and Metabolic Diseases
C4553478	BXGD023543	Infantile Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4554601	BXGD023566	Amyloidosis cutis dyschromia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C4703473	BXGD023650	Atherosclerotic lesion	Cardiovascular Diseases
C4704955	BXGD023687	Infant Overweight	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4704956	BXGD023688	Adolescent Overweight	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4733092	BXGD023907	estrogen receptor-negative breast cancer

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0003364	Cerebroside		299.49
BXGC0003705	Chloride		35.45
BXGC0003803	Oleanolic acid 3-acetate		498.75
BXGC0006466	Oleanolic acid		456.71
BXGC0012843	N-[(2S,3R,4E,8E)-1,3-Dihydroxyoctadeca-4,8-Dien-2-Yl]Hexadecanamide		535.5
BXGC0030612	tetraethylene glycol		194.12
BXGC0035226	Betulinic Acid		456.36
BXGC0047088	Ursolic Acid		456.36
BXGC0050194	alpha-D-Mannose		180.06

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}