Showing entry for Inositol 1,4,5-trisphosphate receptor type 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007754
Protein NameInositol 1,4,5-trisphosphate receptor type 1
Uniport IdP11881
GeneItpr1
Gene Id16438
DomainIns145_P3_rec; Ion_trans; MIR; RIH_assoc; RYDR_ITPR
Pfam PF08709   PF00520   PF02815   PF08454   PF01365  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0032469 endoplasmic reticulum calcium ion homeostasis
Biological Process GO:0042045 epithelial fluid transport
Biological Process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process GO:0097421 liver regeneration
Biological Process GO:0050849 negative regulation of calcium-mediated signaling
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0051928 positive regulation of calcium ion transport
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:2000347 positive regulation of hepatocyte proliferation
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0009791 post-embryonic development
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0050882 voluntary musculoskeletal movement
molecular function GO:0019855 calcium channel inhibitor activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0015278 calcium-release channel activity
molecular function GO:0042802 identical protein binding
molecular function GO:0070679 inositol 1,4,5 trisphosphate binding
molecular function GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
molecular function GO:0044325 ion channel binding
molecular function GO:0035091 phosphatidylinositol binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0019903 protein phosphatase binding
cellular component GO:0005955 calcineurin complex
cellular component GO:0005737 cytoplasm
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0030425 dendrite
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0030176 integral component of endoplasmic reticulum membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0045121 membrane raft
cellular component GO:0043025 neuronal cell body
cellular component GO:0005635 nuclear envelope
cellular component GO:0005637 nuclear inner membrane
cellular component GO:0005730 nucleolus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0031088 platelet dense granule membrane
cellular component GO:0031094 platelet dense tubular network
cellular component GO:0098794 postsynapse
cellular component GO:0014069 postsynaptic density
cellular component GO:0098793 presynapse
cellular component GO:0032991 protein-containing complex
cellular component GO:0016529 sarcoplasmic reticulum
cellular component GO:0030667 secretory granule membrane
cellular component GO:0030868 smooth endoplasmic reticulum membrane
cellular component GO:0097060 synaptic membrane
cellular component GO:0030658 transport vesicle membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein