Showing entry for Alpha-actinin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007847
Protein NameAlpha-actinin-1
Uniport IdP12814
GeneACTN1
Gene Id87
DomainCH; EFhand_Ca_insen; Spectrin
Pfam PF00307   PF08726   PF00435  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04520 Adherens junction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05146 Amoebiasis
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051764 actin crosslink formation
Biological Process GO:0051017 actin filament bundle assembly
Biological Process GO:0051639 actin filament network formation
Biological Process GO:0007015 actin filament organization
Biological Process GO:0048041 focal adhesion assembly
Biological Process GO:0051271 negative regulation of cellular component movement
Biological Process GO:0002576 platelet degranulation
Biological Process GO:0030220 platelet formation
Biological Process GO:0036344 platelet morphogenesis
Biological Process GO:0042981 regulation of apoptotic process
molecular function GO:0051015 actin filament binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0003725 double-stranded RNA binding
molecular function GO:0005178 integrin binding
molecular function GO:0044325 ion channel binding
molecular function GO:0030374 nuclear receptor transcription coactivator activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0099186 structural constituent of postsynapse
molecular function GO:0017166 vinculin binding
cellular component GO:0005903 brush border
cellular component GO:0005911 cell-cell junction
cellular component GO:0042995 cell projection
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005916 fascia adherens
cellular component GO:0005925 focal adhesion
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005886 plasma membrane
cellular component GO:0031093 platelet alpha granule lumen
cellular component GO:0031143 pseudopodium
cellular component GO:0001726 ruffle
cellular component GO:0001725 stress fiber
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114608 Platelet degranulation
R-HSA-1474244 Extracellular matrix organization
R-HSA-1500931 Cell-Cell communication
R-HSA-1500931 Cell-Cell communication
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-373753 Nephrin family interactions
R-HSA-446353 Cell-extracellular matrix interactions
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-HSA-446728 Cell junction organization
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0032181 BXGD002332 Platelet Count measurement
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0085662 BXGD003230 Macrocytosis
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0206157 BXGD004165 Myopathies, Nemaline Musculoskeletal Diseases; Nervous System Diseases
C0206687 BXGD004242 Carcinoma, Endometrioid Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0221278 BXGD004435 Anisocytosis
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1096367 BXGD011618 Increased mean platelet volume
C1269955 BXGD012005 Tumor Cell Invasion
C1701940 BXGD013526 Pneumonia, Ventilator-Associated Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases
C1739105 BXGD013729 Platelet anisocytosis
C2698117 BXGD017446 Anisocyte Measurement
C2751260 BXGD017694 Macrothrombocytopenia Hemic and Lymphatic Diseases
C3554663 BXGD019231 BLEEDING DISORDER, PLATELET-TYPE, 15
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C3828530 BXGD019744 Platelet Component Distribution Width Measurement
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4304021 BXGD022570 Autosomal dominant macrothrombocytopenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002616 Copper 63.55
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein