Showing entry for Sodium/potassium-transporting ATPase subunit alpha-3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007933
Protein NameSodium/potassium-transporting ATPase subunit alpha-3
Uniport IdP13637
GeneATP1A3
Gene Id478
DomainCation_ATPase; Cation_ATPase_C; Cation_ATPase_N; E1-E2_ATPase
Pfam PF00689   PF00690  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04918 Thyroid hormone synthesis
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.5 Excretory system hsa04960 Aldosterone-regulated sodium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04964 Proximal tubule bicarbonate reclamation
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04973 Carbohydrate digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04974 Protein digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:0030007 cellular potassium ion homeostasis
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0071383 cellular response to steroid hormone stimulus
Biological Process GO:0006883 cellular sodium ion homeostasis
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:1990535 neuron projection maintenance
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:1902600 proton transmembrane transport
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0060075 regulation of resting membrane potential
Biological Process GO:1903416 response to glycoside
Biological Process GO:0036376 sodium ion export across plasma membrane
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0005524 ATP binding
molecular function GO:0051087 chaperone binding
molecular function GO:0046872 metal ion binding
molecular function GO:0005391 sodium:potassium-exchanging ATPase activity
molecular function GO:1990239 steroid hormone binding
cellular component GO:0030424 axon
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:1903561 extracellular vesicle
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0032809 neuronal cell body membrane
cellular component GO:0098984 neuron to neuron synapse
cellular component GO:0031090 organelle membrane
cellular component GO:0001917 photoreceptor inner segment
cellular component GO:0060342 photoreceptor inner segment membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0005890 sodium:potassium-exchanging ATPase complex
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-5663205 Infectious disease
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005587 BXGD000316 Depression, Bipolar Mental Disorders
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007760 BXGD000476 Cerebellar Diseases Nervous System Diseases
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013132 BXGD000799 Drooling Stomatognathic Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018572 BXGD001206 Hand, Foot and Mouth Disease Infections
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018989 BXGD001263 Hemiparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0018991 BXGD001264 Hemiplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0021479 BXGD001506 INJECTED EYE Pathological Conditions, Signs and Symptoms; Eye Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0024713 BXGD001799 Manic Disorder Mental Disorders
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026884 BXGD001945 Mutism Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027126 BXGD001976 Myotonic Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036346 BXGD002602 Schizophrenia, Childhood Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0040485 BXGD002871 Torticollis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085583 BXGD003194 Choreoathetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085637 BXGD003219 Oculogyric crisis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0154830 BXGD003746 Proliferative diabetic retinopathy Pathological Conditions, Signs and Symptoms; Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0178417 BXGD004025 Anhedonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0220766 BXGD004341 Congenital hypoplasia of adrenal gland Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C0221163 BXGD004395 Motor Disorders Mental Disorders
C0221263 BXGD004427 Cafe-au-Lait Spots Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0231471 BXGD004494 Abnormal posture Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234162 BXGD004627 Cerebellar Dysmetria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234379 BXGD004662 Resting Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234518 BXGD004683 Slurred speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0236780 BXGD004828 Mixed bipolar I disorder Mental Disorders
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242423 BXGD005164 Ramsay Hunt Paralysis Syndrome Nervous System Diseases
C0242698 BXGD005189 Ventricular Dysfunction, Left Cardiovascular Diseases
C0262444 BXGD005244 Abnormality of the dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0266039 BXGD005612 Taurodontism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0270790 BXGD006105 Quadriparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270862 BXGD006125 Hemiplegic migraine Nervous System Diseases
C0271091 BXGD006160 Retinoschisis, Juvenile, X-Linked Eye Diseases
C0278110 BXGD006497 Hemiplegia, Crossed Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0338488 BXGD007189 Alternating hemiplegia of childhood Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0342482 BXGD007486 X-linked Adrenal Hypoplasia Endocrine System Diseases
C0393588 BXGD008100 Dystonia, Paroxysmal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0393610 BXGD008107 Dystonia, Diurnal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0426980 BXGD008599 Motor symptoms
C0427190 BXGD008611 Ataxia, Truncal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0432123 BXGD008724 Sagittal craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0457756 BXGD008897 Tooth absent
C0497202 BXGD009055 Abnormal ocular motility
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0520966 BXGD009128 Abnormal coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0579144 BXGD009555 Cavovarus deformity of foot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0728829 BXGD009917 Congenital pes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0730278 BXGD009940 Severe nonproliferative diabetic retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0743841 BXGD010085 Disorder characterized by fever Pathological Conditions, Signs and Symptoms
C0750937 BXGD010259 Ataxia, Appendicular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751093 BXGD010317 Dystonia, Limb Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752097 BXGD010659 Autosomal Dominant Juvenile Parkinson Disease Nervous System Diseases
C0752098 BXGD010660 Autosomal Dominant Parkinsonism Nervous System Diseases
C0752100 BXGD010661 Autosomal Recessive Parkinsonism Nervous System Diseases
C0752101 BXGD010662 Parkinsonism, Experimental Nervous System Diseases
C0752104 BXGD010663 Familial Juvenile Parkinsonism Nervous System Diseases
C0752105 BXGD010664 Parkinsonism, Juvenile Nervous System Diseases
C0752203 BXGD010692 Dystonia, Primary Nervous System Diseases
C0813217 BXGD010854 Expressionless face Nervous System Diseases
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1720189 BXGD013668 Episodic Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1832466 BXGD013847 CAPOS syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1834570 BXGD013981 Myoclonic dystonia Nervous System Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1839364 BXGD014371 Progressive visual loss
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1843156 BXGD014561 Progressive sensorineural hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1844813 BXGD014679 Widely spaced teeth
C1845050 BXGD014703 PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1852197 BXGD015264 MAJOR AFFECTIVE DISORDER 1 Mental Disorders
C1852271 BXGD015268 Auditory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1857287 BXGD015692 Stroke-like episode Nervous System Diseases; Cardiovascular Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859236 BXGD015867 Prolonged neonatal jaundice Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1863062 BXGD016151 Episodic quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1865322 BXGD016313 MIGRAINE, FAMILIAL HEMIPLEGIC, 2 Nervous System Diseases
C1868675 BXGD016520 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE Nervous System Diseases
C1868681 BXGD016524 DYSTONIA 12 Nervous System Diseases
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1970943 BXGD016852 MAJOR AFFECTIVE DISORDER 4 Mental Disorders
C1970945 BXGD016853 MAJOR AFFECTIVE DISORDER 6 Mental Disorders
C2363747 BXGD017101 Neurological decompensation
C2700438 BXGD017469 MAJOR AFFECTIVE DISORDER 7 Mental Disorders
C2700439 BXGD017470 MAJOR AFFECTIVE DISORDER 8 Mental Disorders
C2700440 BXGD017471 MAJOR AFFECTIVE DISORDER 9 Mental Disorders
C2732267 BXGD017551 Auditory neuropathy spectrum disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C2751842 BXGD017746 PARKINSON DISEASE 14, AUTOSOMAL RECESSIVE Nervous System Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3549447 BXGD019124 ALTERNATING HEMIPLEGIA OF CHILDHOOD 1
C3553788 BXGD019189 ALTERNATING HEMIPLEGIA OF CHILDHOOD 2
C3554568 BXGD019222 Young adult onset
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021808 BXGD020796 Abnormality of earlobe
C4022010 BXGD020866 Maternal seizures
C4024976 BXGD021509 Episodic generalized hypotonia
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4552072 BXGD023482 X-linked infantile spasms Nervous System Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003690 Glucokinin 764.94
BXGC0015208 Getiacaulein 288.06
BXGC0020220 panaxatriol 476.39
BXGC0022544 Digoxin 780.43
BXGC0023461 methylswertianin 288.06
BXGC0025733 1,3,5,6-Tetrahydroxyxanthen-9-One 260.03
BXGC0036400 1,3,5-Trihydroxyxanthen-9-One 244.04
BXGC0039507 Digitoxigenin 374.25
BXGC0044158 3,4,5-Trihydroxyxanthen-9-One 244.04
BXGC0048644 1,2,3,7-Tetramethoxyxanthone 316.09
BXGC0050699 \N 260.03
BXGC0051524 Ouabain 584.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein