Showing entry for DNA (cytosine-5)-methyltransferase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007962
Protein NameDNA (cytosine-5)-methyltransferase 1
Uniport IdP13864
GeneDnmt1
Gene Id13433
DomainBAH; DMAP_binding; DNA_methylase; DNMT1-RFD; zf-CXXC
Pfam PF01426   PF06464   PF00145   PF12047   PF02008  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071230 cellular response to amino acid stimulus
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0006325 chromatin organization
Biological Process GO:0044026 DNA hypermethylation
Biological Process GO:0006306 DNA methylation
Biological Process GO:0043045 DNA methylation involved in embryo development
Biological Process GO:0032776 DNA methylation on cytosine
Biological Process GO:0010424 DNA methylation on cytosine within a CG sequence
Biological Process GO:0016458 gene silencing
Biological Process GO:0010216 maintenance of DNA methylation
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0051573 negative regulation of histone H3-K9 methylation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:1905460 negative regulation of vascular associated smooth muscle cell apoptotic process
Biological Process GO:1905931 negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
Biological Process GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0051571 positive regulation of histone H3-K4 methylation
Biological Process GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0042493 response to drug
Biological Process GO:0046500 S-adenosylmethionine metabolic process
molecular function GO:0003682 chromatin binding
molecular function GO:0003886 DNA (cytosine-5-)-methyltransferase activity
molecular function GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
molecular function GO:0003677 DNA binding
molecular function GO:0009008 DNA-methyltransferase activity
molecular function GO:0030331 estrogen receptor binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0008327 methyl-CpG binding
molecular function GO:0008168 methyltransferase activity
molecular function GO:1990841 promoter-specific chromatin binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0003723 RNA binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0000792 heterochromatin
cellular component GO:0043025 neuronal cell body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005721 pericentric heterochromatin
cellular component GO:0032991 protein-containing complex
cellular component GO:0005657 replication fork
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein