Showing entry for 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007978
Protein Name3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Uniport IdP14060
GeneHSD3B1
Gene Id3283
Domain3Beta_HSD
Pfam PF01073  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.2 Endocrine system hsa04913 Ovarian steroidogenesis
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006702 androgen biosynthetic process
Biological Process GO:0008207 C21-steroid hormone metabolic process
Biological Process GO:0006703 estrogen biosynthetic process
Biological Process GO:0006704 glucocorticoid biosynthetic process
Biological Process GO:0021766 hippocampus development
Biological Process GO:0006705 mineralocorticoid biosynthetic process
Biological Process GO:0051412 response to corticosterone
Biological Process GO:0006694 steroid biosynthetic process
molecular function GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
molecular function GO:0000253 3-keto sterol reductase activity
molecular function GO:0047024 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
molecular function GO:0102294 cholesterol dehydrogenase activity
molecular function GO:0016491 oxidoreductase activity
molecular function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
molecular function GO:0004769 steroid delta-isomerase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0045171 intercellular bridge
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005758 mitochondrial intermembrane space
cellular component GO:0005730 nucleolus
cellular component GO:0030868 smooth endoplasmic reticulum membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-193048 Androgen biosynthesis
R-HSA-193993 Mineralocorticoid biosynthesis
R-HSA-194002 Glucocorticoid biosynthesis
R-HSA-196071 Metabolism of steroid hormones
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001144 BXGD000028 Acne Vulgaris Skin and Connective Tissue Diseases
C0001430 BXGD000054 Adenoma Neoplasms
C0001622 BXGD000065 Adrenal Gland Hyperfunction Endocrine System Diseases
C0001627 BXGD000068 Congenital adrenal hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007097 BXGD000424 Carcinoma Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008043 BXGD000513 Chiari-Frommel Syndrome Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009777 BXGD000630 Conn Adenoma Neoplasms; Endocrine System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020514 BXGD001414 Hyperprolactinemia Nervous System Diseases; Endocrine System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0041182 BXGD002896 Trophoblastic Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149940 BXGD003391 Sciatic Neuropathy Nervous System Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0268398 BXGD005933 Familial lichen amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0271183 BXGD006169 Severe myopia Eye Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677936 BXGD009737 Refractory cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0702166 BXGD009912 Acne Skin and Connective Tissue Diseases
C0747845 BXGD010184 early pregnancy
C0852036 BXGD010934 Pregnancy associated hypertension Female Urogenital Diseases and Pregnancy Complications; Cardiovascular Diseases
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1333482 BXGD012633 Exaggerated placental site Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1384514 BXGD012940 Conn Syndrome Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C2936858 BXGD018147 Congenital adrenal hyperplasia due to 21 hydroxylase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4302896 BXGD022547 Hormone sensitive prostate cancer Neoplasms; Male Urogenital Diseases
C4721208 BXGD023733 Metastatic castration-resistant prostate cancer
C4727179 BXGD023860 Castration-Sensitive Prostate Carcinoma
C4759295 BXGD024098 Non-metastatic prostate cancer Neoplasms; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0017757 Androstenedione 286.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein