Showing entry for Junction plakoglobin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008069
Protein NameJunction plakoglobin
Uniport IdP14923
GeneJUP
Gene Id3728
DomainArm
Pfam PF00514  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05202 Transcriptional misregulation in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05221 Acute myeloid leukemia
6. Human Diseases 6.2 Cancers: Specific types hsa05226 Gastric cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034332 adherens junction organization
Biological Process GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0016477 cell migration
Biological Process GO:0071681 cellular response to indole-3-methanol
Biological Process GO:0070268 cornification
Biological Process GO:0002159 desmosome assembly
Biological Process GO:0050982 detection of mechanical stimulus
Biological Process GO:0071603 endothelial cell-cell adhesion
Biological Process GO:0031424 keratinization
Biological Process GO:0043537 negative regulation of blood vessel endothelial cell migration
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0001954 positive regulation of cell-matrix adhesion
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:0098911 regulation of ventricular cardiac muscle cell action potential
molecular function GO:0045294 alpha-catenin binding
molecular function GO:0045296 cadherin binding
molecular function GO:0050839 cell adhesion molecule binding
molecular function GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
molecular function GO:0106006 cytoskeletal protein-membrane anchor activity
molecular function GO:0035257 nuclear hormone receptor binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0005198 structural molecule activity
molecular function GO:0003713 transcription coactivator activity
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0005912 adherens junction
cellular component GO:0016327 apicolateral plasma membrane
cellular component GO:0016342 catenin complex
cellular component GO:0005911 cell-cell junction
cellular component GO:0001533 cornified envelope
cellular component GO:0005737 cytoplasm
cellular component GO:0009898 cytoplasmic side of plasma membrane
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0030057 desmosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005916 fascia adherens
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0005925 focal adhesion
cellular component GO:0071665 gamma-catenin-TCF7L2 complex
cellular component GO:0014704 intercalated disc
cellular component GO:0005882 intermediate filament
cellular component GO:0016328 lateral plasma membrane
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0032993 protein-DNA complex
cellular component GO:0035580 specific granule lumen
cellular component GO:0030018 Z disc
cellular component GO:0005915 zonula adherens
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1500931 Cell-Cell communication
R-HSA-162582 Signal Transduction
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-194138 Signaling by VEGF
R-HSA-418990 Adherens junctions interactions
R-HSA-421270 Cell-cell junction organization
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-446728 Cell junction organization
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-6798695 Neutrophil degranulation
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000887 BXGD000017 Acantholysis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0000889 BXGD000018 Acanthosis Nigricans Skin and Connective Tissue Diseases
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0008924 BXGD000574 Cleft upper lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0011071 BXGD000696 Sudden death Pathological Conditions, Signs and Symptoms
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0027443 BXGD001992 Natal Teeth
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0030591 BXGD002247 Paroxysmal ventricular tachycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0037268 BXGD002675 Skin Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0079153 BXGD003064 Hyperkeratosis, Epidermolytic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085615 BXGD003206 Right bundle branch block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085661 BXGD003229 Onycholysis Skin and Connective Tissue Diseases
C0086565 BXGD003295 Liver Dysfunction Digestive System Diseases
C0151636 BXGD003451 Premature ventricular contractions Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151970 BXGD003511 Ulcer of esophagus Digestive System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205851 BXGD004132 Germ cell tumor Neoplasms
C0206656 BXGD004219 Embryonal Rhabdomyosarcoma Neoplasms
C0221260 BXGD004424 Dystrophia unguium Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0221270 BXGD004430 Acanthosis Pathological Conditions, Signs and Symptoms
C0232347 BXGD004540 No-Reflow Phenomenon Pathological Conditions, Signs and Symptoms
C0235475 BXGD004750 Wide QRS complex
C0241181 BXGD005084 Fragile skin
C0265998 BXGD005600 ANONYCHIA Pathological Conditions, Signs and Symptoms
C0279014 BXGD006623 Childhood Germ Cell Tumor Neoplasms
C0343073 BXGD007597 Wooly hair Skin and Connective Tissue Diseases
C0344424 BXGD007669 Ventricular Arrhythmia by ECG Finding
C0348617 BXGD007877 Other cardiomyopathies Cardiovascular Diseases
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0520888 BXGD009120 Inverted T wave Cardiovascular Diseases
C0558165 BXGD009449 Curly hair (finding)
C0677055 BXGD009715 CARCINOMA OF VULVA Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0853945 BXGD010986 Oral mucosal blisters
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1336708 BXGD012852 Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1832600 BXGD013861 Naxos disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C1857042 BXGD015669 Sparse scalp hair
C1862863 BXGD016138 Sparse body hair
C1864826 BXGD016253 Epidermolysis bullosa, lethal acantholytic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1883529 BXGD016597 Ventricular Arrhythmia, CTCAE 3.0
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1969081 BXGD016754 Arrhythmogenic Right Ventricular Dysplasia, Familial, 12 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C2063326 BXGD016902 Right ventricular cardiomyopathy Cardiovascular Diseases
C2713615 BXGD017506 Slow-Flow Phenomenon Pathological Conditions, Signs and Symptoms
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C3900101 BXGD020109 Adult Germ Cell Tumor Neoplasms
C4282407 BXGD022423 Sparse and thin eyebrow
C4531287 BXGD023213 Abnormal morphology of right ventricular trabeculae
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4553764 BXGD023550 Ventricular Arrhythmia, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002682 Zinc 65.41
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein