Showing entry for Insulin receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008097
Protein NameInsulin receptor
Uniport IdP15208
GeneInsr
Gene Id16337
Domainfn3; Furin-like; Insulin_TMD; Pkinase_Tyr; Recep_L_domain
Pfam PF00041   PF00757   PF17870   PF07714   PF01030  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0032148 activation of protein kinase B activity
Biological Process GO:0030325 adrenal gland development
Biological Process GO:0097242 amyloid-beta clearance
Biological Process GO:0048856 anatomical structure development
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0097062 dendritic spine maintenance
Biological Process GO:0008544 epidermis development
Biological Process GO:0031017 exocrine pancreas development
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0008584 male gonad development
Biological Process GO:0030238 male sex determination
Biological Process GO:0007275 multicellular organism development
Biological Process GO:2000252 negative regulation of feeding behavior
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0032410 negative regulation of transporter activity
Biological Process GO:1990535 neuron projection maintenance
Biological Process GO:0038083 peptidyl-tyrosine autophosphorylation
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0048639 positive regulation of developmental growth
Biological Process GO:0046326 positive regulation of glucose import
Biological Process GO:0045725 positive regulation of glycogen biosynthetic process
Biological Process GO:0045821 positive regulation of glycolytic process
Biological Process GO:0010560 positive regulation of glycoprotein biosynthetic process
Biological Process GO:0033674 positive regulation of kinase activity
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0051446 positive regulation of meiotic cell cycle
Biological Process GO:0045840 positive regulation of mitotic nuclear division
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0042327 positive regulation of phosphorylation
Biological Process GO:0043243 positive regulation of protein-containing complex disassembly
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0002092 positive regulation of receptor internalization
Biological Process GO:0060267 positive regulation of respiratory burst
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:2000194 regulation of female gonad development
Biological Process GO:0010310 regulation of hydrogen peroxide metabolic process
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0031667 response to nutrient levels
Biological Process GO:0034612 response to tumor necrosis factor
Biological Process GO:0019087 transformation of host cell by virus
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0043423 3-phosphoinositide-dependent protein kinase binding
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0005524 ATP binding
molecular function GO:0038024 cargo receptor activity
molecular function GO:0005525 GTP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0005009 insulin-activated receptor activity
molecular function GO:0043559 insulin binding
molecular function GO:0031994 insulin-like growth factor I binding
molecular function GO:0031995 insulin-like growth factor II binding
molecular function GO:0005159 insulin-like growth factor receptor binding
molecular function GO:0043560 insulin receptor substrate binding
molecular function GO:0031405 lipoic acid binding
molecular function GO:0043548 phosphatidylinositol 3-kinase binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0051425 PTB domain binding
molecular function GO:0005198 structural molecule activity
molecular function GO:0004714 transmembrane receptor protein tyrosine kinase activity
cellular component GO:0030424 axon
cellular component GO:0005901 caveola
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0032590 dendrite membrane
cellular component GO:0005768 endosome
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005899 insulin receptor complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005770 late endosome
cellular component GO:0005764 lysosome
cellular component GO:0016020 membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0032809 neuronal cell body membrane
cellular component GO:0005635 nuclear envelope
cellular component GO:0031981 nuclear lumen
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
cellular component GO:0055038 recycling endosome membrane
cellular component GO:0045202 synapse
cellular component GO:0060417 yolk
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0032288 5-[1-(4-Hydroxy-Benzyl)-4-(4-Methoxy-Benzyl)-1H-Imidazol-2-Ylamino]-3-Methyl-Imidazole-2,4-Dione 419.16
BXGC0037487 5-[5-(4-Hydroxy-Benzyl)-4-(4-Methoxy-Benzyl)-1-Methyl-1H-Imidazol-2-Ylamino]-3-Methyl-Imidazole-2,4-Dione 433.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein