protein

Showing entry for eIF-2-alpha kinase GCN2

General Target Information
BXGT Id	BXGT008124
Protein Name	eIF-2-alpha kinase GCN2
Uniport Id	P15442
Gene	GCN2
Gene Id	851877
Domain	HGTP_anticodon2; Pkinase; RWD; tRNA-synt_His
Pfam	PF12745 PF00069 PF05773 PF13393
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0034198	cellular response to amino acid starvation
Biological Process	GO:0072755	cellular response to benomyl
Biological Process	GO:0071232	cellular response to histidine
Biological Process	GO:0070301	cellular response to hydrogen peroxide
Biological Process	GO:1990451	cellular stress response to acidic pH
Biological Process	GO:0000077	DNA damage checkpoint
Biological Process	GO:0100002	negative regulation of protein kinase activity by protein phosphorylation
Biological Process	GO:1904262	negative regulation of TORC1 signaling
Biological Process	GO:1903833	positive regulation of cellular response to amino acid starvation
Biological Process	GO:0016239	positive regulation of macroautophagy
Biological Process	GO:0071264	positive regulation of translational initiation in response to starvation
Biological Process	GO:0046777	protein autophosphorylation
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0060733	regulation of eIF2 alpha phosphorylation by amino acid starvation
Biological Process	GO:0006446	regulation of translational initiation
Biological Process	GO:0006412	translation
molecular function	GO:0005524	ATP binding
molecular function	GO:0003725	double-stranded RNA binding
molecular function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity
molecular function	GO:0042803	protein homodimerization activity
molecular function	GO:0004672	protein kinase activity
molecular function	GO:0004860	protein kinase inhibitor activity
molecular function	GO:0043621	protein self-association
molecular function	GO:0043023	ribosomal large subunit binding
molecular function	GO:0043022	ribosome binding
molecular function	GO:0031369	translation initiation factor binding
molecular function	GO:0000049	tRNA binding
cellular component	GO:0022626	cytosolic ribosome
cellular component	GO:0015934	large ribosomal subunit
cellular component	GO:0042788	polysomal ribosome
cellular component	GO:0015935	small ribosomal subunit

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09
BXGC0002588	Magnesium		24.31

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}