Showing entry for Alpha-N-acetylgalactosaminidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008277
Protein NameAlpha-N-acetylgalactosaminidase
Uniport IdP17050
GeneNAGA
Gene Id4668
DomainMelibiase_2; Melibiase_2_C
Pfam PF16499   PF17450  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0016052 carbohydrate catabolic process
Biological Process GO:0019377 glycolipid catabolic process
Biological Process GO:0016139 glycoside catabolic process
Biological Process GO:0046477 glycosylceramide catabolic process
Biological Process GO:0009311 oligosaccharide metabolic process
molecular function GO:0004557 alpha-galactosidase activity
molecular function GO:0008456 alpha-N-acetylgalactosaminidase activity
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005737 cytoplasm
cellular component GO:0070062 extracellular exosome
cellular component GO:0005764 lysosome
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002986 BXGD000165 Fabry Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024236 BXGD001752 Lymphedema Hemic and Lymphatic Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0040264 BXGD002857 Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0040921 BXGD002888 Trichomonas Infections Infections
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151811 BXGD003478 Subcutaneous nodule Neoplasms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234133 BXGD004624 Extrapyramidal sign
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238621 BXGD004947 Aminoaciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270724 BXGD006092 Infantile Neuroaxonal Dystrophy Nervous System Diseases
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0332563 BXGD006894 Papule Pathological Conditions, Signs and Symptoms
C0338473 BXGD007182 Neuroaxonal Dystrophies Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0375206 BXGD007973 Hemiplegia/hemiparesis
C0423250 BXGD008476 Corneal stromal opacities Eye Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0751716 BXGD010565 Adult Neuroaxonal Dystrophy Nervous System Diseases
C0751717 BXGD010566 Juvenile Neuroaxonal Dystrophy Nervous System Diseases
C0751718 BXGD010567 Late Infantile Neuroaxonal Dystrophy Nervous System Diseases
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1263857 BXGD011900 Peripheral axonal neuropathy Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1389113 BXGD012965 Generalized amyotrophy
C1519353 BXGD013236 Skin Papule Skin and Connective Tissue Diseases
C1836522 BXGD014125 Schindler Disease, Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1836525 BXGD014126 White mater abnormalities in the posterior periventricular region Pathological Conditions, Signs and Symptoms
C1836527 BXGD014127 Distal sensory impairment of all modalities
C1836533 BXGD014128 Increased urinary O-linked sialopeptides
C1836542 BXGD014129 Depressed nasal bridge
C1836543 BXGD014130 Thick vermilion border
C1836544 BXGD014131 Schindler Disease, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1836545 BXGD014132 Schindler Disease, Type III Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1837496 BXGD014240 Axonal degeneration
C1839739 BXGD014400 Thick lower lip vermilion
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1850601 BXGD015159 Abnormality of brainstem morphology
C1857697 BXGD015739 Lip telangiectasia
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1963094 BXGD016681 Dry Skin, CTCAE
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C3279222 BXGD018751 Aplasia/Hypoplasia of the cerebellum
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4022018 BXGD020872 Telangiectasia of the skin Cardiovascular Diseases
C4024882 BXGD021455 Telangiectasia of the oral mucosa
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4048329 BXGD021904 Immunosuppression
C4316870 BXGD022707 Abnormality of the eye
C4553743 BXGD023548 Spasticity, CTCAE
C4553962 BXGD023553 Hyperkeratosis, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0004277 Acetic acid 60.05
BXGC0005620 beta-D-Glucopyranose 180.16
BXGC0005625 alpha-D-Glucopyranose 180.16
BXGC0006198 Citric acid 192.12
BXGC0018397 beta-1,4-mannan 180.06
BXGC0027956 SHU 508 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein