Showing entry for S-adenosylmethionine decarboxylase proenzyme


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008331
Protein NameS-adenosylmethionine decarboxylase proenzyme
Uniport IdP17707
GeneAMD1
Gene Id262
DomainSAM_decarbox
Pfam PF01536  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00270 Cysteine and methionine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00330 Arginine and proline metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006595 polyamine metabolic process
Biological Process GO:0006557 S-adenosylmethioninamine biosynthetic process
Biological Process GO:0046500 S-adenosylmethionine metabolic process
Biological Process GO:0008295 spermidine biosynthetic process
Biological Process GO:0006597 spermine biosynthetic process
molecular function GO:0004014 adenosylmethionine decarboxylase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0019810 putrescine binding
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-351202 Metabolism of polyamines
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0010495 BXGD000674 Cutis Laxa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021167 BXGD001487 Incontinence Nervous System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027092 BXGD001971 Myopia Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035312 BXGD002531 Retinal Drusen Eye Diseases
C0042164 BXGD002965 Uveitis Eye Diseases
C0042693 BXGD002996 Violence
C0085635 BXGD003217 Photopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0154830 BXGD003746 Proliferative diabetic retinopathy Pathological Conditions, Signs and Symptoms; Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0242852 BXGD005197 Proliferative vitreoretinopathy Eye Diseases
C0271066 BXGD006156 Choroidal retinal neovascularization Pathological Conditions, Signs and Symptoms; Eye Diseases
C0271084 BXGD006159 Exudative age-related macular degeneration Eye Diseases
C0271093 BXGD006162 Stargardt's disease
C0271183 BXGD006169 Severe myopia Eye Diseases
C0271214 BXGD006174 Central blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0271215 BXGD006175 Blindness, Legal Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0339508 BXGD007256 Hereditary macular dystrophy
C0339543 BXGD007267 Epiretinal Membrane Eye Diseases
C0342751 BXGD007542 Generalized glycogen storage disease of infants Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0687132 BXGD009839 heavy drinking
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0730285 BXGD009943 Diabetic macular edema Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0730292 BXGD009947 Macular dystrophy Eye Diseases
C0917796 BXGD011408 Optic Atrophy, Hereditary, Leber Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C1260959 BXGD011846 Drusen
C1269955 BXGD012005 Tumor Cell Invasion
C1288283 BXGD012175 Atrophoderma maculatum Skin and Connective Tissue Diseases
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1301509 BXGD012294 Severe visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1504336 BXGD013137 Polypoidal choroidal vasculopathy
C1536085 BXGD013334 Geographic Atrophy Eye Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1658953 BXGD013486 tumor vasculature
C1719777 BXGD013660 Hard drusen
C1720452 BXGD013674 Soft drusen
C1855465 BXGD015498 STARGARDT DISEASE 1 (disorder)
C2237660 BXGD016962 exudative macular degeneration Eye Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2362324 BXGD017091 Pediatric Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2609315 BXGD017179 Retinal angiomatous proliferation
C2748203 BXGD017585 Vitreomacular adhesion
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3665335 BXGD019275 Cutis laxa, autosomal recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3888896 BXGD019990 Wet age-related macular degeneration
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000985 Putrescine 88.15
BXGC0005881 Urea 60.06
BXGC0038275 Pyruvic Acid 88.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein