Showing entry for Estrogen receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008514
Protein NameEstrogen receptor
Uniport IdP19785
GeneEsr1
Gene Id13982
DomainESR1_C; Hormone_recep; Oest_recep; zf-C4
Pfam PF12743   PF00104   PF02159   PF00105  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008209 androgen metabolic process
Biological Process GO:0001547 antral ovarian follicle growth
Biological Process GO:0071392 cellular response to estradiol stimulus
Biological Process GO:0071391 cellular response to estrogen stimulus
Biological Process GO:0002064 epithelial cell development
Biological Process GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
Biological Process GO:0030520 intracellular estrogen receptor signaling pathway
Biological Process GO:0030518 intracellular steroid hormone receptor signaling pathway
Biological Process GO:0008584 male gonad development
Biological Process GO:0060749 mammary gland alveolus development
Biological Process GO:0060745 mammary gland branching involved in pregnancy
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0046325 negative regulation of glucose import
Biological Process GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0045839 negative regulation of mitotic nuclear division
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process GO:0048662 negative regulation of smooth muscle cell proliferation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0090209 negative regulation of triglyceride metabolic process
Biological Process GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0050679 positive regulation of epithelial cell proliferation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0048146 positive regulation of fibroblast proliferation
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0051000 positive regulation of nitric-oxide synthase activity
Biological Process GO:0010863 positive regulation of phospholipase C activity
Biological Process GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
Biological Process GO:0060523 prostate epithelial cord elongation
Biological Process GO:0071168 protein localization to chromatin
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0060687 regulation of branching involved in prostate gland morphogenesis
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0043523 regulation of neuron apoptotic process
Biological Process GO:0034121 regulation of toll-like receptor signaling pathway
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0032355 response to estradiol
Biological Process GO:0043627 response to estrogen
Biological Process GO:0060011 Sertoli cell proliferation
Biological Process GO:0048863 stem cell differentiation
Biological Process GO:0060065 uterus development
Biological Process GO:0060068 vagina development
molecular function GO:0051117 ATPase binding
molecular function GO:0008013 beta-catenin binding
molecular function GO:0003682 chromatin binding
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0019899 enzyme binding
molecular function GO:0030284 estrogen receptor activity
molecular function GO:0030331 estrogen receptor binding
molecular function GO:0034056 estrogen response element binding
molecular function GO:0042562 hormone binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004879 nuclear receptor activity
molecular function GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
molecular function GO:1990841 promoter-specific chromatin binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0070491 repressing transcription factor binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0001226 RNA polymerase II transcription corepressor binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
molecular function GO:0005496 steroid binding
molecular function GO:0003707 steroid hormone receptor activity
molecular function GO:0017025 TBP-class protein binding
molecular function GO:0001093 TFIIB-class transcription factor binding
molecular function GO:0001223 transcription coactivator binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0031798 type 1 metabotropic glutamate receptor binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005739 mitochondrion
cellular component GO:0043005 neuron projection
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005634 nucleus
cellular component GO:0043204 perikaryon
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0043195 terminal bouton
cellular component GO:0035327 transcriptionally active chromatin
cellular component GO:0097550 transcription preinitiation complex
cellular component GO:0030315 T-tubule
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0001325 Progesterone 314.46
BXGC0001767 (E)-Resveratrol 228.25
BXGC0003707 Estrogen 268.36
BXGC0006362 Estrone 270.37
BXGC0019164 Raloxifene 473.17
BXGC0030094 Paroxypropione 150.07
BXGC0034968 Dienestrol 266.13
BXGC0036535 dehydrodiconiferyl alcohol 358.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein