Showing entry for L-serine dehydratase/L-threonine deaminase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008546
Protein NameL-serine dehydratase/L-threonine deaminase
Uniport IdP20132
GeneSDS
Gene Id10993
DomainPALP
Pfam PF00291  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00260 Glycine, serine and threonine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00270 Cysteine and methionine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00290 Valine, leucine and isoleucine biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
1. Metabolism 1.0 Global and overview maps hsa01230 Biosynthesis of amino acids
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0009097 isoleucine biosynthetic process
Biological Process GO:0006565 L-serine catabolic process
Biological Process GO:0019518 L-threonine catabolic process to glycine
Biological Process GO:0042866 pyruvate biosynthetic process
Biological Process GO:0006567 threonine catabolic process
Biological Process GO:0006566 threonine metabolic process
molecular function GO:0003941 L-serine ammonia-lyase activity
molecular function GO:0004794 L-threonine ammonia-lyase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0030170 pyridoxal phosphate binding
cellular component GO:0005829 cytosol
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-8849175 Threonine catabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003125 BXGD000179 Anorexia Nervosa Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004245 BXGD000264 Atrioventricular Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007129 BXGD000439 Merkel cell carcinoma Neoplasms; Infections
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007279 BXGD000457 Carotid Body Paraganglioma Neoplasms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009186 BXGD000590 Coccidioidomycosis Infections
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013338 BXGD000816 Pituitary dwarfism Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0014850 BXGD000957 Esophageal Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018553 BXGD001203 Hamartoma Syndrome, Multiple Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0019562 BXGD001336 Von Hippel-Lindau Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027662 BXGD002015 Multiple Endocrine Neoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0027672 BXGD002020 Neoplastic Syndromes, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030421 BXGD002218 Paraganglioma Neoplasms
C0030422 BXGD002219 Extra-Adrenal Paraganglioma Neoplasms
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031485 BXGD002303 Phenylketonurias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0032268 BXGD002341 Pneumocephalus Nervous System Diseases; Wounds and Injuries
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0033893 BXGD002439 Tension Headache Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037221 BXGD002673 Situs Inversus Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040896 BXGD002887 Trichinellosis Infections
C0041296 BXGD002903 Tuberculosis Infections
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0042769 BXGD002999 Virus Diseases Infections
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0162671 BXGD003971 MELAS Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0205770 BXGD004121 Choroid Plexus Papilloma Neoplasms; Nervous System Diseases
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235222 BXGD004731 Diastolic hypertension Nervous System Diseases; Cardiovascular Diseases
C0236053 BXGD004808 Mucosal ulcer Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0238462 BXGD004937 Medullary carcinoma of thyroid Neoplasms; Endocrine System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0265338 BXGD005522 Coffin-Siris syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Stomatognathic Diseases; Behavior and Behavior Mechanisms
C0268563 BXGD005988 Sarcosinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0271561 BXGD006213 Somatotropin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0272170 BXGD006312 Shwachman syndrome
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0312414 BXGD006886 Menstrual spotting
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0342777 BXGD007547 Succinate-coenzyme Q reductase deficiency
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0745133 BXGD010118 Isolated systolic hypertension
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0795690 BXGD010728 Congenital omphalocele Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0848332 BXGD010879 Spots on skin Skin and Connective Tissue Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0949857 BXGD011589 Mitochondrial Respiratory Chain Deficiencies Nutritional and Metabolic Diseases
C1096184 BXGD011607 West Nile viral infection Infections; Nervous System Diseases
C1175175 BXGD011797 Severe Acute Respiratory Syndrome Infections; Respiratory Tract Diseases
C1257877 BXGD011812 Pheochromocytoma, Extra-Adrenal Neoplasms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1333001 BXGD012578 Childhood Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1333944 BXGD012657 Paraganglioma of head and neck Neoplasms
C1333993 BXGD012673 hereditary paraganglioma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C1334699 BXGD012731 Mesenchymal Cell Neoplasm Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1519176 BXGD013232 Salivary Gland Pleomorphic Adenoma Neoplasms; Stomatognathic Diseases
C1533592 BXGD013316 Malignant Paraganglionic Neoplasm Neoplasms
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1561826 BXGD013364 Overweight and obesity
C1611743 BXGD013456 Familial (FPAH)
C1708350 BXGD013598 Hereditary Leiomyomatosis and Renal Cell Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1832370 BXGD013832 MYOPATHY, MYOFIBRILLAR, DESMIN-RELATED Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1855008 BXGD015449 Mitochondrial Complex II Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1858592 BXGD015812 Carney Triad Digestive System Diseases; Neoplasms; Respiratory Tract Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3264382 BXGD018591 Swine influenza virus (viruses that normally cause infections in pigs)
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714796 BXGD019434 Isolated somatotropin deficiency
C4020732 BXGD020474 Mitochondrial abnormalities
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0028981 Serine 105.04
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein