Showing entry for Ephrin-A1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008606
Protein NameEphrin-A1
Uniport IdP20827
GeneEFNA1
Gene Id1942
DomainEphrin
Pfam PF00812  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001525 angiogenesis
Biological Process GO:0003180 aortic valve morphogenesis
Biological Process GO:0007411 axon guidance
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0016477 cell migration
Biological Process GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0003183 mitral valve morphogenesis
Biological Process GO:0061002 negative regulation of dendritic spine morphogenesis
Biological Process GO:0010719 negative regulation of epithelial to mesenchymal transition
Biological Process GO:0043409 negative regulation of MAPK cascade
Biological Process GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process
Biological Process GO:0070244 negative regulation of thymocyte apoptotic process
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0014028 notochord formation
Biological Process GO:1902004 positive regulation of amyloid-beta formation
Biological Process GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0061098 positive regulation of protein tyrosine kinase activity
Biological Process GO:0050821 protein stabilization
Biological Process GO:0045765 regulation of angiogenesis
Biological Process GO:0050770 regulation of axonogenesis
Biological Process GO:0043535 regulation of blood vessel endothelial cell migration
Biological Process GO:0033628 regulation of cell adhesion mediated by integrin
Biological Process GO:0050730 regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0034446 substrate adhesion-dependent cell spreading
molecular function GO:0046875 ephrin receptor binding
molecular function GO:0005102 signaling receptor binding
cellular component GO:0046658 anchored component of plasma membrane
cellular component GO:0005576 extracellular region
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003857 BXGD000228 Congenital arteriovenous malformation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0017525 BXGD001112 Giant Cell Tumors Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0021841 BXGD001519 Intestinal Neoplasms Digestive System Diseases; Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0206656 BXGD004219 Embryonal Rhabdomyosarcoma Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0233407 BXGD004576 Disorientation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278504 BXGD006523 Non-small cell lung cancer stage I
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1142339 BXGD011750 Intestinal adenoma
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1302652 BXGD012307 Adenoma of rectum Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1658953 BXGD013486 tumor vasculature
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein