Showing entry for Phosphatidylcholine translocator ABCB4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008649
Protein NamePhosphatidylcholine translocator ABCB4
Uniport IdP21439
GeneABCB4
Gene Id5244
DomainABC_membrane; ABC_tran
Pfam PF00664   PF00005  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.1 Membrane transport hsa02010 ABC transporters
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032782 bile acid secretion
Biological Process GO:1903413 cellular response to bile acid
Biological Process GO:0099040 ceramide translocation
Biological Process GO:0055088 lipid homeostasis
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0045332 phospholipid translocation
Biological Process GO:0032376 positive regulation of cholesterol transport
Biological Process GO:0061092 positive regulation of phospholipid translocation
Biological Process GO:2001140 positive regulation of phospholipid transport
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:1901557 response to fenofibrate
Biological Process GO:0055085 transmembrane transport
molecular function GO:0016887 ATPase activity
molecular function GO:0042626 ATPase-coupled transmembrane transporter activity
molecular function GO:0005524 ATP binding
molecular function GO:0090554 phosphatidylcholine floppase activity
molecular function GO:0005548 phospholipid transporter activity
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0016324 apical plasma membrane
cellular component GO:0030136 clathrin-coated vesicle
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0046581 intercellular canaliculus
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-1989781 PPARA activates gene expression
R-HSA-382551 Transport of small molecules
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
R-HSA-5619084 ABC transporter disorders
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-5678771 Defective ABCB4 causes PFIC3, ICP3 and GBD1
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005699 BXGD000325 Blast Phase Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008311 BXGD000526 Cholangitis Digestive System Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0008325 BXGD000529 Cholecystitis Digestive System Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0008354 BXGD000533 Cholera Infections
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0008372 BXGD000535 Intrahepatic Cholestasis Digestive System Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0015930 BXGD001025 Fetal Distress Pathological Conditions, Signs and Symptoms
C0016977 BXGD001086 Gall Bladder Diseases Digestive System Diseases
C0016978 BXGD001087 gallbladder neoplasm Digestive System Diseases; Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019189 BXGD001298 Hepatitis, Chronic Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0022354 BXGD001540 Jaundice, Obstructive Pathological Conditions, Signs and Symptoms
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023486 BXGD001668 Prolymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023892 BXGD001715 Biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032131 BXGD002330 Plasmacytoma Neoplasms; Immune System Diseases
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0042769 BXGD002999 Virus Diseases Infections
C0079588 BXGD003084 Ichthyosis, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0086565 BXGD003295 Liver Dysfunction Digestive System Diseases
C0149841 BXGD003372 Benign recurrent intrahepatic cholestasis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0151849 BXGD003486 Alkaline phosphatase raised Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0201836 BXGD004052 Alanine aminotransferase measurement
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0221152 BXGD004392 Obstipation Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0235874 BXGD004781 Disease Exacerbation Pathological Conditions, Signs and Symptoms
C0238065 BXGD004869 Secondary Biliary Cholangitis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242216 BXGD005141 Biliary calculi Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0267792 BXGD005775 Hepatobiliary disease Digestive System Diseases
C0267818 BXGD005781 Bile duct proliferation Digestive System Diseases
C0268312 BXGD005894 Progressive intrahepatic cholestasis (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0268318 BXGD005896 Cholestasis of pregnancy Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications
C0278134 BXGD006498 Absence of sensation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0280248 BXGD006726 stage, chronic lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0332853 BXGD006901 Anastomosis
C0333027 BXGD006917 Microlithiasis Pathological Conditions, Signs and Symptoms
C0339985 BXGD007296 Idiopathic bronchiectasis Respiratory Tract Diseases
C0341439 BXGD007408 Chronic liver disease Digestive System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0520571 BXGD009092 Fibrosis of bile duct Digestive System Diseases
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0586358 BXGD009605 Biliary Intraepithelial Neoplasia Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0742395 BXGD010062 Cholestasis, chronic
C0745744 BXGD010133 End Stage Liver Disease Digestive System Diseases
C0746102 BXGD010136 Chronic lung disease Respiratory Tract Diseases
C0750952 BXGD010263 Biliary Tract Cancer Digestive System Diseases; Neoplasms
C0796149 BXGD010804 Scott Syndrome Hemic and Lymphatic Diseases
C0856727 BXGD011108 Cholesterol gallstones Digestive System Diseases
C0860204 BXGD011219 Cholestatic liver disease Digestive System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0920027 BXGD011453 Cholestatic hepatic disorder
C0947622 BXGD011493 Cholecystolithiasis Digestive System Diseases
C1263666 BXGD011889 Advanced cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C1279296 BXGD012118 Chronic leukemia (category) Pathological Conditions, Signs and Symptoms; Neoplasms
C1292777 BXGD012236 Aggressive natural killer-cell leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1314665 BXGD012386 Serum alkaline phosphatase raised
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1333177 BXGD012605 Lymphoproliferative Disorder of the Skin Skin and Connective Tissue Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C1443924 BXGD013074 Severe diarrhea Pathological Conditions, Signs and Symptoms
C1445957 BXGD013081 Serum total cholesterol measurement
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1848701 BXGD014967 Elevated hepatic transaminase
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1858556 BXGD015805 OVERLAP CONNECTIVE TISSUE DISEASE Eye Diseases; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C1865643 BXGD016337 Cholestasis, progressive familial intrahepatic 3 Digestive System Diseases
C1868683 BXGD016526 B-CELL MALIGNANCY, LOW-GRADE
C1883008 BXGD016593 Serum Alanine Aminotransferase Measurement
C1963165 BXGD016685 Malabsorption, CTCAE
C2004489 BXGD016873 Regurgitation
C2004493 BXGD016875 Leukemia, B-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2609268 BXGD017175 Low phospholipid-associated cholelithiasis Digestive System Diseases
C2676033 BXGD017322 Hepatoblastoma Caused By Somatic Mutation Digestive System Diseases; Neoplasms
C2717836 BXGD017510 Steroid Sulfatase Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C2936476 BXGD018123 Chronic Liver Failure Digestive System Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3489728 BXGD018944 Familial intrahepatic cholestasis of pregnancy Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications
C3489789 BXGD018948 Cholestasis, Progressive Familial Intrahepatic, 2 Digestive System Diseases
C3544266 BXGD019113 Hepatobiliary cancer
C3554241 BXGD019206 CHOLESTASIS, INTRAHEPATIC, OF PREGNANCY 3
C3665858 BXGD019308 Parenteral nutrition associated liver disease
C3666017 BXGD019318 Cholangiopathy
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3805083 BXGD019459 Portal fibrosis Digestive System Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4021882 BXGD020827 Increased serum bile acid concentration during pregnancy
C4021883 BXGD020828 Abnormal liver function tests during pregnancy
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4520983 BXGD023052 Congenital atresia of extrahepatic bile duct Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4551595 BXGD023367 Biliary Cirrhosis, Primary, 1 Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C4551898 BXGD023434 Cholestasis, progressive familial intrahepatic 1 Digestive System Diseases
C4551899 BXGD023435 Cholestasis, benign recurrent intrahepatic 1 Digestive System Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0022544 Digoxin 780.43
BXGC0025658 Vinblastine 810.42
BXGC0027421 Paclitaxel 853.33
BXGC0038316 Cholesterol 386.35
BXGC0044017 Verapamil 454.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein