Showing entry for Cadherin-3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008744
Protein NameCadherin-3
Uniport IdP22223
GeneCDH3
Gene Id1001
DomainCadherin; Cadherin_C
Pfam PF00028   PF01049  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04514 Cell adhesion molecules (CAMs)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034332 adherens junction organization
Biological Process GO:0007155 cell adhesion
Biological Process GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
Biological Process GO:0022405 hair cycle process
Biological Process GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Biological Process GO:0031424 keratinization
Biological Process GO:0051796 negative regulation of timing of catagen
Biological Process GO:0032912 negative regulation of transforming growth factor beta2 production
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
Biological Process GO:0010838 positive regulation of keratinocyte proliferation
Biological Process GO:0048023 positive regulation of melanin biosynthetic process
Biological Process GO:1902910 positive regulation of melanosome transport
Biological Process GO:0032773 positive regulation of monophenol monooxygenase activity
Biological Process GO:0060901 regulation of hair cycle by canonical Wnt signaling pathway
Biological Process GO:0042493 response to drug
Biological Process GO:0001895 retina homeostasis
Biological Process GO:0007601 visual perception
Biological Process GO:0042060 wound healing
molecular function GO:0045296 cadherin binding
molecular function GO:0005509 calcium ion binding
cellular component GO:0005912 adherens junction
cellular component GO:0016342 catenin complex
cellular component GO:0030054 cell junction
cellular component GO:0005737 cytoplasm
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1500931 Cell-Cell communication
R-HSA-418990 Adherens junctions interactions
R-HSA-421270 Cell-cell junction organization
R-HSA-446728 Cell junction organization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010093 BXGD000652 Corpus Luteum Cyst Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013575 BXGD000854 Ectodermal Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0016689 BXGD001073 Freckles Skin and Connective Tissue Diseases
C0020678 BXGD001463 Hypotrichosis Skin and Connective Tissue Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027962 BXGD002064 Melanocytic nevus Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029927 BXGD002182 Ovarian Cysts Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0039075 BXGD002788 Syndactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0158113 BXGD003875 Contracture of joint of hand Musculoskeletal Diseases
C0206694 BXGD004245 Mucoepidermoid Carcinoma Neoplasms
C0221352 BXGD004444 Syndactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0221369 BXGD004453 Acquired Camptodactyly
C0221373 BXGD004454 Claw hand Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0237653 BXGD004847 Immunologic hypersensitivity
C0240340 BXGD005031 Microdontia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0263490 BXGD005314 Brittle hair
C0263491 BXGD005315 Pili Torti Skin and Connective Tissue Diseases
C0265554 BXGD005548 Ectrodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0268398 BXGD005933 Familial lichen amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0338106 BXGD007167 Adenocarcinoma of colon Digestive System Diseases; Neoplasms
C0339508 BXGD007256 Hereditary macular dystrophy
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346629 BXGD007831 Malignant neoplasm of large intestine Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0423867 BXGD008517 Fine hair
C0427460 BXGD008616 Red cell distribution width determination
C0431448 BXGD008691 Absent eyebrow Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0677898 BXGD009735 invasive cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685409 BXGD009810 Congenital Camptodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0730292 BXGD009947 Macular dystrophy Eye Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1333869 BXGD012654 Pancreatic Intraepithelial Neoplasia-1
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1739135 BXGD013733 Progression of prostate cancer
C1832162 BXGD013804 HYPOTRICHOSIS, CONGENITAL, WITH JUVENILE MACULAR DYSTROPHY Eye Diseases; Skin and Connective Tissue Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1837315 BXGD014218 COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
C1843300 BXGD014572 Sparse eyelashes
C1844813 BXGD014679 Widely spaced teeth
C1857041 BXGD015668 Ectodermal dysplasia, ectrodactyly, and macular dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C1857042 BXGD015669 Sparse scalp hair
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1862863 BXGD016138 Sparse body hair
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1962966 BXGD016678 Retinopathy, CTCAE
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1970308 BXGD016833 Selective tooth agenesis
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675481 BXGD017292 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
C2677123 BXGD017364 COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
C2699510 BXGD017460 Split-Hand/Foot Malformation Pathological Conditions, Signs and Symptoms
C2751290 BXGD017695 CHOROIDAL DYSTROPHY, CENTRAL AREOLAR 2 Eye Diseases
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C2919142 BXGD017867 Short Stature, CTCAE
C2931019 BXGD017938 Split hand foot deformity 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C3554460 BXGD019215 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
C4024756 BXGD021405 Abnormality of macular pigmentation
C4025846 BXGD021826 Abnormality of vision
C4048273 BXGD021898 Chorioretinal atrophy Eye Diseases
C4082761 BXGD022092 Abnormality of limb bone morphology
C4282407 BXGD022423 Sparse and thin eyebrow
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4553962 BXGD023553 Hyperkeratosis, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721530 BXGD023750 Congenital hypotrichia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein