Showing entry for Liver carboxylesterase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008830
Protein NameLiver carboxylesterase 1
Uniport IdP23141
GeneCES1
Gene Id1066
DomainCOesterase
Pfam PF00135  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002003 angiotensin maturation
Biological Process GO:0071397 cellular response to cholesterol
Biological Process GO:0071404 cellular response to low-density lipoprotein particle stimulus
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0090122 cholesterol ester hydrolysis involved in cholesterol transport
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0051791 medium-chain fatty acid metabolic process
Biological Process GO:0010887 negative regulation of cholesterol storage
Biological Process GO:0010875 positive regulation of cholesterol efflux
Biological Process GO:0090205 positive regulation of cholesterol metabolic process
Biological Process GO:0070857 regulation of bile acid biosynthetic process
Biological Process GO:0120188 regulation of bile acid secretion
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0043691 reverse cholesterol transport
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0052689 carboxylic ester hydrolase activity
molecular function GO:0080030 methyl indole-3-acetate esterase activity
molecular function GO:0047374 methylumbelliferyl-acetate deacetylase activity
molecular function GO:0004771 sterol esterase activity
molecular function GO:0004806 triglyceride lipase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005615 extracellular space
cellular component GO:0005811 lipid droplet
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
R-HSA-211859 Biological oxidations
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-2980736 Peptide hormone metabolism
R-HSA-392499 Metabolism of proteins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008384 BXGD000537 Cholesterol Ester Storage Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0009171 BXGD000587 Cocaine Abuse Chemically-Induced Disorders; Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013238 BXGD000806 Dry Eye Syndromes Eye Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023364 BXGD001638 Leptospirosis Infections
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025303 BXGD001858 Meningococcal Infections Infections
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0027412 BXGD001985 Opioid-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028860 BXGD002093 Oculocerebrorenal Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0029095 BXGD002108 Opioid abuse Chemically-Induced Disorders; Mental Disorders
C0041296 BXGD002903 Tuberculosis Infections
C0043208 BXGD003039 Wolman Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236736 BXGD004825 Cocaine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279584 BXGD006641 Childhood B Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0279593 BXGD006644 Adult B Acute Lymphoblastic Leukemia
C0314719 BXGD006890 Dryness of eye Eye Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349636 BXGD007941 Pre B-cell acute lymphoblastic leukemia
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524661 BXGD009237 Narcotic Abuse Chemically-Induced Disorders; Mental Disorders
C0524662 BXGD009238 Opiate Addiction Chemically-Induced Disorders; Mental Disorders
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1527402 BXGD013288 Narcotic Dependence Chemically-Induced Disorders; Mental Disorders
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2745948 BXGD017569 Hyalinosis, Systemic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C2938940 BXGD018168 Post stroke depression Mental Disorders
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C4551628 BXGD023373 Opiate Abuse Chemically-Induced Disorders; Mental Disorders
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4748035 BXGD023979 DRUG METABOLISM, ALTERED, CES1-RELATED
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002400 Ethyl acetate 88.11
BXGC0002675 Sugars 342.3
BXGC0002698 Fluorine 19
BXGC0003456 1,4-Benzoquinone 108.09
BXGC0003705 Chloride 35.45
BXGC0003817 Miltiorone 282.38
BXGC0004145 2,3-Heptanedione 128.17
BXGC0004206 3-Methyl-1,2-cyclopentanedione 112.13
BXGC0004245 2,3-Pentanedione 100.12
BXGC0004280 2,4-Pentanedione 100.12
BXGC0004560 Benzoic acid 122.12
BXGC0004569 Benzophenone 182.22
BXGC0005049 4-Methylumbelliferyl acetate 218.21
BXGC0005513 Hexadecanoic acid 256.42
BXGC0005658 (S)-2-Methylbutanoic acid 102.13
BXGC0005697 2,3-Butanedione 86.09
BXGC0006021 3-Methyl-1,2-cyclohexanedione 126.15
BXGC0007060 1-Phenyl-1,2-propanedione 148.16
BXGC0007542 11-Deoxoglycyrrhetinic acid 456.7
BXGC0009122 Zein 174.19
BXGC0011627 Glycyrrhetic acid 470.69
BXGC0021948 Bavachinin A 338.15
BXGC0026391 Naloxone 327.15
BXGC0027962 indan 118.08
BXGC0028001 Beta-Lapachone 242.09
BXGC0031291 Tanshinone Iia Sulfonate 373.07
BXGC0032126 Alisol A 490.37
BXGC0033130 Benzoin 212.08
BXGC0033921 Isatin 147.03
BXGC0036541 Dibenzoylmethane 224.08
BXGC0037599 Tanshinone Iia 294.13
BXGC0039579 Methyl Glycyrrhetinate 484.36
BXGC0039601 Levocarnitine 161.11
BXGC0041912 Heroin 369.16
BXGC0043272 alisol A 24-acetate 532.38
BXGC0044167 6-O-monoacetylmorphine 327.15
BXGC0044778 Oseltamivir 312.2
BXGC0048135 3,4-phenanthrenequinone 208.05
BXGC0049115 indene 116.06
BXGC0050317 Acetoxolone 512.35
BXGC0050651 Cryptotanshinone 296.14
BXGC0051398 Indole 117.06
BXGC0051976 n.a 474.37
BXGC0052948 Tanshinone I 276.08
BXGC0053767 Dihydrotanshinone I 278.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein