Showing entry for Glycine receptor subunit alpha-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008864
Protein NameGlycine receptor subunit alpha-1
Uniport IdP23415
GeneGLRA1
Gene Id2741
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007340 acrosome reaction
Biological Process GO:0001508 action potential
Biological Process GO:0007628 adult walking behavior
Biological Process GO:0071230 cellular response to amino acid stimulus
Biological Process GO:0071361 cellular response to ethanol
Biological Process GO:0071294 cellular response to zinc ion
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0006821 chloride transport
Biological Process GO:0060080 inhibitory postsynaptic potential
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006811 ion transport
Biological Process GO:0006936 muscle contraction
Biological Process GO:0051970 negative regulation of transmission of nerve impulse
Biological Process GO:0050877 nervous system process
Biological Process GO:0050884 neuromuscular process controlling posture
Biological Process GO:0007218 neuropeptide signaling pathway
Biological Process GO:2000344 positive regulation of acrosome reaction
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0002087 regulation of respiratory gaseous exchange by nervous system process
Biological Process GO:0097305 response to alcohol
Biological Process GO:0043200 response to amino acid
Biological Process GO:0060013 righting reflex
Biological Process GO:0007165 signal transduction
Biological Process GO:0001964 startle response
Biological Process GO:0060012 synaptic transmission, glycinergic
Biological Process GO:0007601 visual perception
molecular function GO:0016934 extracellularly glycine-gated chloride channel activity
molecular function GO:0016594 glycine binding
molecular function GO:0042802 identical protein binding
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0030977 taurine binding
molecular function GO:0004888 transmembrane signaling receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
molecular function GO:0008270 zinc ion binding
cellular component GO:0044305 calyx of Held
cellular component GO:0034707 chloride channel complex
cellular component GO:0030425 dendrite
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0098690 glycinergic synapse
cellular component GO:0060077 inhibitory synapse
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099060 integral component of postsynaptic specialization membrane
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014550 BXGD000930 Myoclonic Epilepsy Nervous System Diseases
C0014868 BXGD000965 Esophagitis Digestive System Diseases
C0015644 BXGD001008 Muscular fasciculation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0019337 BXGD001319 Heroin Dependence Chemically-Induced Disorders; Mental Disorders
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037771 BXGD002702 Paraparesis, Spastic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085292 BXGD003153 Stiff-Person Syndrome Immune System Diseases; Nervous System Diseases
C0086439 BXGD003284 Hypokinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0220787 BXGD004345 Endotracheal aspiration
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0234166 BXGD004628 Hyperexplexia Nervous System Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0393598 BXGD008104 Idiopathic familial dystonia Nervous System Diseases
C0393719 BXGD008128 Nocturnal epilepsy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0557874 BXGD009444 Global developmental delay
C0563625 BXGD009484 Agnosia for Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0700198 BXGD009877 Pulmonary aspiration Respiratory Tract Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0740302 BXGD009975 5q-syndrome Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0743332 BXGD010081 Focal Dystonia Nervous System Diseases
C0748605 BXGD010200 nocturnal seizures
C0752197 BXGD010686 Adult-Onset Dystonias Nervous System Diseases
C0752198 BXGD010687 Adult-Onset Idiopathic Focal Dystonias Nervous System Diseases
C0752199 BXGD010688 Adult-Onset Idiopathic Torsion Dystonias Nervous System Diseases
C0752200 BXGD010689 Autosomal Dominant Familial Dystonia Nervous System Diseases
C0752201 BXGD010690 Autosomal Recessive Familial Dystonia Nervous System Diseases
C0752202 BXGD010691 Childhood Onset Dystonias Nervous System Diseases
C0752203 BXGD010692 Dystonia, Primary Nervous System Diseases
C0752205 BXGD010693 Dystonia, Secondary Nervous System Diseases
C0752206 BXGD010694 Dystonias, Sporadic Nervous System Diseases
C0752207 BXGD010695 Familial Dystonia Nervous System Diseases
C0752208 BXGD010696 Pseudodystonia Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1292779 BXGD012238 Myelodysplastic Syndrome with Isolated del(5q) Hemic and Lymphatic Diseases
C1305855 BXGD012348 Body mass index
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1611743 BXGD013456 Familial (FPAH)
C1740801 BXGD013744 Exaggerated startle response
C1802398 BXGD013758 Chromosome 5, trisomy 5q Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1835614 BXGD014039 Hereditary Hyperexplexia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1861457 BXGD016052 PROGRESSIVE ENCEPHALOMYELITIS WITH RIGIDITY Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases; Nervous System Diseases
C1963221 BXGD016690 Aspiration, CTCAE
C2712334 BXGD017486 Actual Aspiration
C2827071 BXGD017792 Unintentional Material Aspiration
C3489393 BXGD018928 Hiatal Hernia Pathological Conditions, Signs and Symptoms
C3553291 BXGD019167 HYPEREKPLEXIA 2
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4084968 BXGD022110 Hereditary Hyperekplexia Immune System Diseases; Nervous System Diseases
C4255079 BXGD022311 Familial Hyperekplexia Immune System Diseases; Nervous System Diseases
C4316810 BXGD022702 Writer's Cramp Nervous System Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4551954 BXGD023446 HYPEREKPLEXIA 1 Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C4553743 BXGD023548 Spasticity, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000434 Ethanol 46.07
BXGC0000664 Maxepa 314.46
BXGC0002374 Taurine 125.15
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
BXGC0003102 Acetylcholine 146.21
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0005867 Serotonin 176.22
BXGC0008379 Ginkgolide B 424.4
BXGC0008380 Ginkgolide A 408.4
BXGC0012228 Vitamin D 384.64
BXGC0016417 Picrotoxin 310.11
BXGC0017719 Strychnine 334.17
BXGC0030028 (D)-Serine 105.04
BXGC0039213 Ginkgolide M 424.14
BXGC0039791 fructose 180.06
BXGC0040150 Cannabidiol 314.22
BXGC0042179 Atropine 289.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein