Showing entry for Cystic fibrosis transmembrane conductance regulator


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009105
Protein NameCystic fibrosis transmembrane conductance regulator
Uniport IdP26361
GeneCftr
Gene Id12638
DomainABC_membrane; ABC_tran; CFTR_R
Pfam PF00664   PF00005   PF14396  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015701 bicarbonate transport
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:1904322 cellular response to forskolin
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0006821 chloride transport
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0030301 cholesterol transport
Biological Process GO:0051454 intracellular pH elevation
Biological Process GO:0015705 iodide transport
Biological Process GO:0030324 lung development
Biological Process GO:0060081 membrane hyperpolarization
Biological Process GO:0050891 multicellular organismal water homeostasis
Biological Process GO:2000077 negative regulation of type B pancreatic cell development
Biological Process GO:1905460 negative regulation of vascular associated smooth muscle cell apoptotic process
Biological Process GO:0097755 positive regulation of blood vessel diameter
Biological Process GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity
Biological Process GO:1904446 positive regulation of establishment of Sertoli cell barrier
Biological Process GO:0045921 positive regulation of exocytosis
Biological Process GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0033005 positive regulation of mast cell activation
Biological Process GO:1902943 positive regulation of voltage-gated chloride channel activity
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0048240 sperm capacitation
Biological Process GO:0030321 transepithelial chloride transport
Biological Process GO:0035377 transepithelial water transport
Biological Process GO:0055085 transmembrane transport
Biological Process GO:0042311 vasodilation
Biological Process GO:0006904 vesicle docking involved in exocytosis
Biological Process GO:0006833 water transport
molecular function GO:0016887 ATPase activity
molecular function GO:0042626 ATPase-coupled transmembrane transporter activity
molecular function GO:0005524 ATP binding
molecular function GO:0015106 bicarbonate transmembrane transporter activity
molecular function GO:0051087 chaperone binding
molecular function GO:0005254 chloride channel activity
molecular function GO:0019869 chloride channel inhibitor activity
molecular function GO:0015108 chloride transmembrane transporter activity
molecular function GO:0019899 enzyme binding
molecular function GO:0005260 intracellularly ATP-gated chloride channel activity
molecular function GO:0016853 isomerase activity
molecular function GO:0030165 PDZ domain binding
molecular function GO:0106138 Sec61 translocon complex binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0009986 cell surface
cellular component GO:0034707 chloride channel complex
cellular component GO:0005737 cytoplasm
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0005769 early endosome
cellular component GO:0031901 early endosome membrane
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0005902 microvillus
cellular component GO:0043025 neuronal cell body
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0055037 recycling endosome
cellular component GO:0055038 recycling endosome membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0004277 Acetic acid 60.05
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein