Showing entry for Threonine--tRNA ligase, cytoplasmic


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009122
Protein NameThreonine--tRNA ligase, cytoplasmic
Uniport IdP26639
GeneTARS1
Gene Id6897
DomainHGTP_anticodon; TGS; tRNA-synt_2b; tRNA_SAD
Pfam PF03129   PF02824   PF00587   PF07973  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa00970 Aminoacyl-tRNA biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006435 threonyl-tRNA aminoacylation
Biological Process GO:0006418 tRNA aminoacylation for protein translation
molecular function GO:0004812 aminoacyl-tRNA ligase activity
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004829 threonine-tRNA ligase activity
molecular function GO:0000049 tRNA binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
Reactome
Pathway Id Pathway Name
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379724 tRNA Aminoacylation
R-HSA-392499 Metabolism of proteins
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023290 BXGD001631 Leishmaniasis, Visceral Infections
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0079154 BXGD003065 Congenital Nonbullous Ichthyosiform Erythroderma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0158353 BXGD003882 Infectious Myositis Musculoskeletal Diseases; Nervous System Diseases
C0263490 BXGD005314 Brittle hair
C0334013 BXGD006978 Phrynoderma Skin and Connective Tissue Diseases
C0544796 BXGD009313 Myositis, Proliferative Musculoskeletal Diseases; Nervous System Diseases
C0751356 BXGD010406 Idiopathic Inflammatory Myopathies Musculoskeletal Diseases; Nervous System Diseases
C0751357 BXGD010407 Myositis, Focal Musculoskeletal Diseases; Nervous System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C3888318 BXGD019967 Myopathy, familial idiopathic inflammatory Musculoskeletal Diseases; Nervous System Diseases
C4073178 BXGD022060 Tiger tail banding
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005753 L-Threonine 119.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein