Showing entry for MAP/microtubule affinity-regulating kinase 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009183
Protein NameMAP/microtubule affinity-regulating kinase 3
Uniport IdP27448
GeneMARK3
Gene Id4140
DomainKA1; Pkinase; UBA
Pfam PF02149   PF00069   PF00627  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0035331 negative regulation of hippo signaling
Biological Process GO:0036289 peptidyl-serine autophosphorylation
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0006468 protein phosphorylation
molecular function GO:0005524 ATP binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0048156 tau protein binding
molecular function GO:0050321 tau-protein kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0070062 extracellular exosome
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5673000 RAF activation
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-9607240 FLT3 Signaling
R-HSA-9649948 Signaling downstream of RAS mutants
R-HSA-9656223 Signaling by RAF1 mutants
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0005890 BXGD000345 Body Height
C0005938 BXGD000351 Bone Density
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0018498 BXGD001195 Hair Color
C0020490 BXGD001403 Hyperopia Eye Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0177804 BXGD004019 Bone Mineral Density Test
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0271007 BXGD006152 Phthisis bulbi Pathological Conditions, Signs and Symptoms; Eye Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0344529 BXGD007687 Cornea plana Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0871470 BXGD011316 Systolic Pressure
C0877015 BXGD011327 Pelvic Organ Prolapse Pathological Conditions, Signs and Symptoms
C3178892 BXGD018545 Pelvic Floor Disorders Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4748978 BXGD024042 VISUAL IMPAIRMENT AND PROGRESSIVE PHTHISIS BULBI
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000655 Harmalol 200.24
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0007014 Harman 182.22
BXGC0013109 4-[2-(3,5-Dihydroxyphenyl)Ethenyl]Benzene-1,2-Diol 244.07
BXGC0024554 D-luciferin 280
BXGC0034256 Rottlerin 516.18
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
BXGC0051873 Sl-0101 516.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein