Showing entry for Genome polyprotein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009215
Protein NameGenome polyprotein
Uniport IdP27958
Gene
Gene Id
DomainFlavi_DEAD; HCV_capsid; HCV_core; HCV_env; HCV_NS1; HCV_NS2; HCV_NS4a; HCV_NS4b; HCV_NS5a; HCV_NS5a_1a; HCV_NS5a_1b; HCV_NS5a_C; Peptidase_S29; RdRP_3
Pfam PF07652   PF01543   PF01542   PF01539   PF01560   PF01538   PF01006   PF01001   PF01506   PF08300   PF08301   PF12941   PF02907   PF00998  
OrganismHepatitis C virus genotype 1a (isolate H) (HCV)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0075512 clathrin-dependent endocytosis of virus by host cell
Biological Process GO:0039654 fusion of virus membrane with host endosome membrane
Biological Process GO:0039520 induction by virus of host autophagy
Biological Process GO:0019054 modulation by virus of host cellular process
Biological Process GO:0039645 modulation by virus of host G1/S transition checkpoint
Biological Process GO:0044833 modulation by virus of host protein transport
Biological Process GO:0019056 modulation by virus of host transcription
Biological Process GO:0002674 negative regulation of acute inflammatory response
Biological Process GO:0032780 negative regulation of ATPase activity
Biological Process GO:0030889 negative regulation of B cell proliferation
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:0050689 negative regulation of defense response to virus by host
Biological Process GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response
Biological Process GO:0060702 negative regulation of endoribonuclease activity
Biological Process GO:1900118 negative regulation of execution phase of apoptosis
Biological Process GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0033673 negative regulation of kinase activity
Biological Process GO:0031953 negative regulation of protein autophosphorylation
Biological Process GO:0050709 negative regulation of protein secretion
Biological Process GO:0090201 negative regulation of release of cytochrome c from mitochondria
Biological Process GO:1900369 negative regulation of RNA interference
Biological Process GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
Biological Process GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
Biological Process GO:0034156 negative regulation of toll-like receptor 7 signaling pathway
Biological Process GO:0034164 negative regulation of toll-like receptor 9 signaling pathway
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
Biological Process GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
Biological Process GO:0039707 pore formation by virus in membrane of host cell
Biological Process GO:1990216 positive regulation by symbiont of host transcription
Biological Process GO:0010694 positive regulation of alkaline phosphatase activity
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1903301 positive regulation of hexokinase activity
Biological Process GO:1903721 positive regulation of I-kappaB phosphorylation
Biological Process GO:0045862 positive regulation of proteolysis
Biological Process GO:0051047 positive regulation of secretion
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
Biological Process GO:0048524 positive regulation of viral process
Biological Process GO:0051259 protein complex oligomerization
Biological Process GO:1900101 regulation of endoplasmic reticulum unfolded protein response
Biological Process GO:0019050 suppression by virus of host apoptotic process
Biological Process GO:0046774 suppression by virus of host intracellular interferon activity
Biological Process GO:0039560 suppression by virus of host IRF9 activity
Biological Process GO:0039545 suppression by virus of host MAVS activity
Biological Process GO:0039644 suppression by virus of host NF-kappaB transcription factor activity
Biological Process GO:0039580 suppression by virus of host PKR activity
Biological Process GO:0039613 suppression by virus of host protein phosphorylation
Biological Process GO:0039563 suppression by virus of host STAT1 activity
Biological Process GO:0039547 suppression by virus of host TRAF activity
Biological Process GO:0039653 suppression by virus of host transcription
Biological Process GO:0039502 suppression by virus of host type I interferon-mediated signaling pathway
Biological Process GO:0019087 transformation of host cell by virus
Biological Process GO:0044053 translocation of peptides or proteins into host cell cytoplasm
Biological Process GO:0046762 viral budding from endoplasmic reticulum membrane
Biological Process GO:0019082 viral protein processing
Biological Process GO:0039694 viral RNA genome replication
Biological Process GO:0019062 virion attachment to host cell
molecular function GO:0016887 ATPase activity
molecular function GO:0060590 ATPase regulator activity
molecular function GO:0005524 ATP binding
molecular function GO:0004197 cysteine-type endopeptidase activity
molecular function GO:0017151 DEAD/H-box RNA helicase binding
molecular function GO:0019899 enzyme binding
molecular function GO:0031072 heat shock protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0005216 ion channel activity
molecular function GO:1990254 keratin filament binding
molecular function GO:0019900 kinase binding
molecular function GO:0042288 MHC class I protein binding
molecular function GO:0002039 p53 binding
molecular function GO:0008233 peptidase activity
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0017137 Rab GTPase binding
molecular function GO:0003723 RNA binding
molecular function GO:0003968 RNA-directed 5'-3' RNA polymerase activity
molecular function GO:0003724 RNA helicase activity
molecular function GO:0005124 scavenger receptor binding
molecular function GO:0004252 serine-type endopeptidase activity
molecular function GO:0008236 serine-type peptidase activity
molecular function GO:0017124 SH3 domain binding
molecular function GO:0097677 STAT family protein binding
molecular function GO:0005198 structural molecule activity
molecular function GO:0035663 Toll-like receptor 2 binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0031369 translation initiation factor binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0039714 cytoplasmic viral factory
cellular component GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
cellular component GO:0005576 extracellular region
cellular component GO:0030430 host cell cytoplasm
cellular component GO:0044164 host cell cytosol
cellular component GO:0044165 host cell endoplasmic reticulum
cellular component GO:0044167 host cell endoplasmic reticulum membrane
cellular component GO:0044177 host cell Golgi apparatus
cellular component GO:0044186 host cell lipid droplet
cellular component GO:0033644 host cell membrane
cellular component GO:0044191 host cell mitochondrial membrane
cellular component GO:0042025 host cell nucleus
cellular component GO:0044220 host cell perinuclear region of cytoplasm
cellular component GO:0020002 host cell plasma membrane
cellular component GO:0033647 host intracellular organelle
cellular component GO:0016021 integral component of membrane
cellular component GO:0044385 integral to membrane of host cell
cellular component GO:0019031 viral envelope
cellular component GO:0019013 viral nucleocapsid
cellular component GO:0055036 virion membrane
Reactome
Pathway Id Pathway Name
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport
R-HSA-8854214 TBC/RABGAPs
R-HSA-9007101 Rab regulation of trafficking
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0018397 beta-1,4-mannan 180.06
BXGC0048845 Guanosine Triphosphate 522.99
BXGC0049447 acetate 59.01
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein