Showing entry for Gamma-aminobutyric acid receptor subunit rho-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009262
Protein NameGamma-aminobutyric acid receptor subunit rho-2
Uniport IdP28476
GeneGABRR2
Gene Id2570
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0007214 gamma-aminobutyric acid signaling pathway
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0050877 nervous system process
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0007165 signal transduction
Biological Process GO:0007601 visual perception
molecular function GO:0005254 chloride channel activity
molecular function GO:0004890 GABA-A receptor activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:0019904 protein domain specific binding
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0034707 chloride channel complex
cellular component GO:1902711 GABA-A receptor complex
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-977443 GABA receptor activation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0035258 BXGD002523 Restless Legs Syndrome Nervous System Diseases; Mental Disorders
C0086565 BXGD003295 Liver Dysfunction Digestive System Diseases
C0149504 BXGD003322 Encephalopathy, Toxic Nervous System Diseases; Chemically-Induced Disorders
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0154659 BXGD003725 Toxic Encephalitis Nervous System Diseases; Chemically-Induced Disorders
C0235032 BXGD004715 Neurotoxicity Syndromes Nervous System Diseases; Chemically-Induced Disorders
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0006108 1H-Imidazole-4(5)-acetic acid 126.11
BXGC0017719 Strychnine 334.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein