Showing entry for Retinoic acid receptor RXR-beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009287
Protein NameRetinoic acid receptor RXR-beta
Uniport IdP28702
GeneRXRB
Gene Id6257
DomainHormone_recep; zf-C4
Pfam PF00104   PF00105  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04920 Adipocytokine signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05202 Transcriptional misregulation in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05216 Thyroid cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05222 Small cell lung cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05223 Non-small cell lung cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05226 Gastric cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0048856 anatomical structure development
Biological Process GO:0030154 cell differentiation
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0032526 response to retinoic acid
Biological Process GO:0048384 retinoic acid receptor signaling pathway
Biological Process GO:0006367 transcription initiation from RNA polymerase II promoter
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0004879 nuclear receptor activity
molecular function GO:0044323 retinoic acid-responsive element binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
molecular function GO:0003707 steroid hormone receptor activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0090575 RNA polymerase II transcription regulator complex
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-556833 Metabolism of lipids
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-HSA-9031525 NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
R-HSA-9031528 NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
R-HSA-9632974 NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024301 BXGD001759 Lymphoma, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0040425 BXGD002863 Tonsillitis Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0205647 BXGD004099 Follicular adenoma Neoplasms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0235874 BXGD004781 Disease Exacerbation Pathological Conditions, Signs and Symptoms
C0343052 BXGD007592 Guttate psoriasis Skin and Connective Tissue Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C2985280 BXGD018223 Blood Protein Measurement
C3495801 BXGD019004 Granulomatosis with polyangiitis Respiratory Tract Diseases; Immune System Diseases; Cardiovascular Diseases
C4050407 BXGD021962 Pauci-immune Glomerulonephritis associated with Granulomatosis with Polyangiitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002244 Doconexent 328.49
BXGC0003705 Chloride 35.45
BXGC0004753 Phthalic acid 166.13
BXGC0013582 Curcumin 368.13
BXGC0016254 Dehydroabietic Acid 300.21
BXGC0019226 (+)-Conocarpan 266.13
BXGC0037354 isopimaric acid 302.22
BXGC0040733 Tetrahydrocurcumin 372.16
BXGC0042413 Calcitriol 416.33
BXGC0051342 Valerenic Acid 234.16
BXGC0052295 Sclareol 308.27
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein