Showing entry for Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009392
Protein NameDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Uniport IdP30038
GeneALDH4A1
Gene Id8659
DomainAldedh
Pfam PF00171  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00330 Arginine and proline metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019470 4-hydroxyproline catabolic process
Biological Process GO:0046487 glyoxylate metabolic process
Biological Process GO:0006562 proline catabolic process
Biological Process GO:0010133 proline catabolic process to glutamate
Biological Process GO:0006560 proline metabolic process
molecular function GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
molecular function GO:0004029 aldehyde dehydrogenase (NAD+) activity
molecular function GO:0009055 electron transfer activity
molecular function GO:0042802 identical protein binding
cellular component GO:0005759 mitochondrial matrix
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-389661 Glyoxylate metabolism and glycine degradation
R-HSA-70688 Proline catabolism
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0268528 BXGD005972 Hyperprolinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268534 BXGD005975 Prolinuria
C0282313 BXGD006803 Condition, Preneoplastic Neoplasms
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0543541 BXGD009285 HYPERGLYCINURIA (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0948585 BXGD011541 Hydroxyprolinuria
C2931835 BXGD018072 Hyperprolinemia type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4529962 BXGD023178 Fatty Liver Disease
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein