Showing entry for Type II inositol 1,4,5-trisphosphate 5-phosphatase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009595
Protein NameType II inositol 1,4,5-trisphosphate 5-phosphatase
Uniport IdP32019
GeneINPP5B
Gene Id3633
DomainExo_endo_phos; INPP5B_PH; RhoGAP
Pfam PF03372   PF16776   PF00620  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0046855 inositol phosphate dephosphorylation
Biological Process GO:0043647 inositol phosphate metabolic process
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0046856 phosphatidylinositol dephosphorylation
Biological Process GO:0070613 regulation of protein processing
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007165 signal transduction
Biological Process GO:0007283 spermatogenesis
molecular function GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
cellular component GO:0005829 cytosol
cellular component GO:0031901 early endosome membrane
cellular component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0030670 phagocytic vesicle membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1483249 Inositol phosphate metabolism
R-HSA-162582 Signal Transduction
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194840 Rho GTPase cycle
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0005890 BXGD000345 Body Height
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0028860 BXGD002093 Oculocerebrorenal Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0156312 BXGD003849 Atrophy of testis Male Urogenital Diseases; Endocrine System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0427460 BXGD008616 Red cell distribution width determination
C0431399 BXGD008684 Familial aplasia of the vermis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Male Urogenital Diseases
C0521707 BXGD009166 Bilateral cataracts (disorder) Eye Diseases
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1845167 BXGD014722 Dent Disease 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein