Showing entry for Guanylate-binding protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009640
Protein NameGuanylate-binding protein 1
Uniport IdP32455
GeneGBP1
Gene Id2633
DomainGBP; GBP_C
Pfam PF02263   PF02841  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071346 cellular response to interferon-gamma
Biological Process GO:0071347 cellular response to interleukin-1
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0051607 defense response to virus
Biological Process GO:0060333 interferon-gamma-mediated signaling pathway
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0032703 negative regulation of interleukin-2 production
Biological Process GO:1903077 negative regulation of protein localization to plasma membrane
Biological Process GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0050860 negative regulation of T cell receptor signaling pathway
Biological Process GO:0072665 protein localization to vacuole
Biological Process GO:0050848 regulation of calcium-mediated signaling
Biological Process GO:1903076 regulation of protein localization to plasma membrane
molecular function GO:0003779 actin binding
molecular function GO:0019955 cytokine binding
molecular function GO:0019899 enzyme binding
molecular function GO:0019003 GDP binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0051879 Hsp90 protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0030507 spectrin binding
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0005576 extracellular region
cellular component GO:0005794 Golgi apparatus
cellular component GO:0000139 Golgi membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0012506 vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System
R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0013371 BXGD000823 Shigella Infections Digestive System Diseases; Infections
C0016065 BXGD001046 Polyostotic fibrous dysplasia Musculoskeletal Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025500 BXGD001874 Mesothelioma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0085437 BXGD003178 Meningitis, Bacterial Infections; Nervous System Diseases
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152244 BXGD003571 Bone Cysts, Aneurysmal Neoplasms; Musculoskeletal Diseases
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0242292 BXGD005146 McCune-Albright Syndrome Musculoskeletal Diseases
C0276138 BXGD006403 Viral myocarditis Infections; Cardiovascular Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398367 BXGD008187 Histiocytic Necrotizing Lymphadenitis Hemic and Lymphatic Diseases
C0585362 BXGD009592 Squamous cell carcinoma of mouth Digestive System Diseases; Neoplasms; Stomatognathic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0851989 BXGD010933 Bone and joint infections
C0854985 BXGD011055 Adenocarcinoma of lung, stage I
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948192 BXGD011514 Primary infection NOS
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1262091 BXGD011867 Lymphocytic infiltration
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1511789 BXGD013183 Desmoplastic
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C2062441 BXGD016897 Influenza A
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4087124 BXGD022132 Immunoglobulin G4-Related Disease Immune System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0027925 Cpg 363.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein