Showing entry for Focal adhesion kinase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009753
Protein NameFocal adhesion kinase 1
Uniport IdP34152
GenePtk2
Gene Id14083
DomainFERM_M; FERM_N_2; Focal_AT; Pkinase_Tyr
Pfam PF00373   PF18038   PF03623   PF07714  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001525 angiogenesis
Biological Process GO:0001568 blood vessel development
Biological Process GO:0030154 cell differentiation
Biological Process GO:0030644 cellular chloride ion homeostasis
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0021955 central nervous system neuron axonogenesis
Biological Process GO:0043542 endothelial cell migration
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0060396 growth hormone receptor signaling pathway
Biological Process GO:0045087 innate immune response
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0007254 JNK cascade
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:2000811 negative regulation of anoikis
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0010507 negative regulation of autophagy
Biological Process GO:0050771 negative regulation of axonogenesis
Biological Process GO:0022408 negative regulation of cell-cell adhesion
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0046621 negative regulation of organ growth
Biological Process GO:0051964 negative regulation of synapse assembly
Biological Process GO:0001764 neuron migration
Biological Process GO:0007097 nuclear migration
Biological Process GO:0038083 peptidyl-tyrosine autophosphorylation
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0097755 positive regulation of blood vessel diameter
Biological Process GO:0010613 positive regulation of cardiac muscle hypertrophy
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0010763 positive regulation of fibroblast migration
Biological Process GO:0060252 positive regulation of glial cell proliferation
Biological Process GO:0010759 positive regulation of macrophage chemotaxis
Biological Process GO:0120041 positive regulation of macrophage proliferation
Biological Process GO:0050766 positive regulation of phagocytosis
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0045860 positive regulation of protein kinase activity
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0014911 positive regulation of smooth muscle cell migration
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0050806 positive regulation of synaptic transmission
Biological Process GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
Biological Process GO:0090303 positive regulation of wound healing
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0033628 regulation of cell adhesion mediated by integrin
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0010632 regulation of epithelial cell migration
Biological Process GO:0051893 regulation of focal adhesion assembly
Biological Process GO:0045667 regulation of osteoblast differentiation
Biological Process GO:0001932 regulation of protein phosphorylation
Biological Process GO:1900024 regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0007172 signal complex assembly
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Biological Process GO:0001570 vasculogenesis
molecular function GO:0003779 actin binding
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0005178 integrin binding
molecular function GO:0008432 JUN kinase binding
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
molecular function GO:0019902 phosphatase binding
molecular function GO:0043548 phosphatidylinositol 3-kinase binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0042169 SH2 domain binding
molecular function GO:0005102 signaling receptor binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0036064 ciliary basal body
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0043197 dendritic spine
cellular component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
cellular component GO:0005925 focal adhesion
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0014704 intercalated disc
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0030027 lamellipodium
cellular component GO:0016604 nuclear body
cellular component GO:0005730 nucleolus
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0098794 postsynapse
cellular component GO:0042383 sarcolemma
cellular component GO:0001725 stress fiber
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0037274 (+)-Alpha-Tocopheryl Succinate 530.4
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein