Showing entry for Tyrosine-protein phosphatase non-receptor type 11


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009801
Protein NameTyrosine-protein phosphatase non-receptor type 11
Uniport IdP35235
GenePtpn11
Gene Id19247
DomainSH2; Y_phosphatase
Pfam PF00017   PF00102  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0033277 abortive mitotic cell cycle
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0036302 atrioventricular canal development
Biological Process GO:0007409 axonogenesis
Biological Process GO:0060020 Bergmann glial cell differentiation
Biological Process GO:0007420 brain development
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0021697 cerebellar cortex formation
Biological Process GO:0000077 DNA damage checkpoint
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0038127 ERBB signaling pathway
Biological Process GO:0060325 face morphogenesis
Biological Process GO:0008543 fibroblast growth factor receptor signaling pathway
Biological Process GO:0048806 genitalia development
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0007507 heart development
Biological Process GO:0048873 homeostasis of number of cells within a tissue
Biological Process GO:0009755 hormone-mediated signaling pathway
Biological Process GO:0042445 hormone metabolic process
Biological Process GO:0048839 inner ear development
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0061582 intestinal epithelial cell migration
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0035855 megakaryocyte development
Biological Process GO:0032528 microvillus organization
Biological Process GO:0048609 multicellular organismal reproductive process
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0033629 negative regulation of cell adhesion mediated by integrin
Biological Process GO:0032331 negative regulation of chondrocyte differentiation
Biological Process GO:0051463 negative regulation of cortisol secretion
Biological Process GO:0060125 negative regulation of growth hormone secretion
Biological Process GO:0046888 negative regulation of hormone secretion
Biological Process GO:0046676 negative regulation of insulin secretion
Biological Process GO:0048011 neurotrophin TRK receptor signaling pathway
Biological Process GO:0035265 organ growth
Biological Process GO:0035335 peptidyl-tyrosine dephosphorylation
Biological Process GO:0048008 platelet-derived growth factor receptor signaling pathway
Biological Process GO:0030220 platelet formation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0046326 positive regulation of glucose import
Biological Process GO:0046887 positive regulation of hormone secretion
Biological Process GO:0046628 positive regulation of insulin receptor signaling pathway
Biological Process GO:0032728 positive regulation of interferon-beta production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0045931 positive regulation of mitotic cell cycle
Biological Process GO:0045778 positive regulation of ossification
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0009967 positive regulation of signal transduction
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0033628 regulation of cell adhesion mediated by integrin
Biological Process GO:0043254 regulation of protein-containing complex assembly
Biological Process GO:0046825 regulation of protein export from nucleus
Biological Process GO:0006641 triglyceride metabolic process
molecular function GO:0045296 cadherin binding
molecular function GO:0050839 cell adhesion molecule binding
molecular function GO:0031748 D1 dopamine receptor binding
molecular function GO:0005158 insulin receptor binding
molecular function GO:0043560 insulin receptor substrate binding
molecular function GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
molecular function GO:0051428 peptide hormone receptor binding
molecular function GO:0043274 phospholipase binding
molecular function GO:0004721 phosphoprotein phosphatase activity
molecular function GO:0001784 phosphotyrosine residue binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0019901 protein kinase binding
molecular function GO:1990782 protein tyrosine kinase binding
molecular function GO:0004725 protein tyrosine phosphatase activity
molecular function GO:0030971 receptor tyrosine kinase binding
molecular function GO:0030159 signaling receptor complex adaptor activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0050651 Cryptotanshinone 296.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein