Showing entry for Prostaglandin G/H synthase 2



                       
General Target Information
BXGT IdBXGT009817
Protein NameProstaglandin G/H synthase 2
Uniport IdP35355
GenePtgs2
Gene Id29527
DomainAn_peroxidase; EGF
Pfam PF03098   PF00008  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0001525 angiogenesis
Biological Process GO:0030282 bone mineralization
Biological Process GO:0050873 brown fat cell differentiation
Biological Process GO:0071318 cellular response to ATP
Biological Process GO:0071498 cellular response to fluid shear stress
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0071284 cellular response to lead ion
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0071471 cellular response to non-ionic osmotic stress
Biological Process GO:0034644 cellular response to UV
Biological Process GO:0019371 cyclooxygenase pathway
Biological Process GO:0046697 decidualization
Biological Process GO:0007566 embryo implantation
Biological Process GO:0042633 hair cycle
Biological Process GO:0006954 inflammatory response
Biological Process GO:0007612 learning
Biological Process GO:0035633 maintenance of blood-brain barrier
Biological Process GO:0007613 memory
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0097756 negative regulation of blood vessel diameter
Biological Process GO:0051926 negative regulation of calcium ion transport
Biological Process GO:0045786 negative regulation of cell cycle
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
Biological Process GO:0045986 negative regulation of smooth muscle contraction
Biological Process GO:0032227 negative regulation of synaptic transmission, dopaminergic
Biological Process GO:0030728 ovulation
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0090336 positive regulation of brown fat cell differentiation
Biological Process GO:0010942 positive regulation of cell death
Biological Process GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0031622 positive regulation of fever generation
Biological Process GO:0090271 positive regulation of fibroblast growth factor production
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0090362 positive regulation of platelet-derived growth factor production
Biological Process GO:0031394 positive regulation of prostaglandin biosynthetic process
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0045987 positive regulation of smooth muscle contraction
Biological Process GO:0031915 positive regulation of synaptic plasticity
Biological Process GO:0051968 positive regulation of synaptic transmission, glutamatergic
Biological Process GO:0071636 positive regulation of transforming growth factor beta production
Biological Process GO:0010575 positive regulation of vascular endothelial growth factor production
Biological Process GO:0045907 positive regulation of vasoconstriction
Biological Process GO:0001516 prostaglandin biosynthetic process
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0150077 regulation of neuroinflammatory response
Biological Process GO:1990776 response to angiotensin
Biological Process GO:0034097 response to cytokine
Biological Process GO:0042493 response to drug
Biological Process GO:0032355 response to estradiol
Biological Process GO:0070542 response to fatty acid
Biological Process GO:0009750 response to fructose
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0010226 response to lithium ion
Biological Process GO:0010042 response to manganese ion
Biological Process GO:0014070 response to organic cyclic compound
Biological Process GO:0010033 response to organic substance
Biological Process GO:0010243 response to organonitrogen compound
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0009314 response to radiation
Biological Process GO:0034612 response to tumor necrosis factor
Biological Process GO:0033280 response to vitamin D
Biological Process GO:0019233 sensory perception of pain
molecular function GO:0019899 enzyme binding
molecular function GO:0020037 heme binding
molecular function GO:0046872 metal ion binding
molecular function GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
molecular function GO:0004601 peroxidase activity
molecular function GO:0004666 prostaglandin-endoperoxide synthase activity
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005637 nuclear inner membrane
cellular component GO:0005640 nuclear outer membrane
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000016 Butein 272.25
BXGC0000470 Chalconaringenin 272.25
BXGC0000663 Papain 206.28
BXGC0003066 Phenols 199.27
BXGC0003397 Lipoxygenase 229.2
BXGC0005682 3,3',4,4'-Tetrahydroxylignan 302.36
BXGC0005683 Quercetin 302.24
BXGC0005793 Baicalein 270.24
BXGC0008707 Isoliquiritigenin 256.25
BXGC0013582 Curcumin 368.13
BXGC0039787 2',4'-Dihydroxychalcone 240.08
BXGC0045252 Sc-560 352.06
BXGC0049858 Chalcone 208.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein