Showing entry for High affinity nerve growth factor receptor



                       
General Target Information
BXGT IdBXGT009861
Protein NameHigh affinity nerve growth factor receptor
Uniport IdP35739
GeneNtrk1
Gene Id59109
DomainLRR_8; Pkinase_Tyr; TPKR_C2
Pfam PF13855   PF07714   PF16920  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0007411 axon guidance
Biological Process GO:0060385 axonogenesis involved in innervation
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0061368 behavioral response to formalin induced pain
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:1990090 cellular response to nerve growth factor stimulus
Biological Process GO:0071316 cellular response to nicotine
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
Biological Process GO:0050965 detection of temperature stimulus involved in sensory perception of pain
Biological Process GO:0060384 innervation
Biological Process GO:0007611 learning or memory
Biological Process GO:0042490 mechanoreceptor differentiation
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:0038180 nerve growth factor signaling pathway
Biological Process GO:0007399 nervous system development
Biological Process GO:0048666 neuron development
Biological Process GO:0031175 neuron projection development
Biological Process GO:0048011 neurotrophin TRK receptor signaling pathway
Biological Process GO:0021553 olfactory nerve development
Biological Process GO:0038083 peptidyl-tyrosine autophosphorylation
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0033674 positive regulation of kinase activity
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0043068 positive regulation of programmed cell death
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0046579 positive regulation of Ras protein signal transduction
Biological Process GO:0051965 positive regulation of synapse assembly
Biological Process GO:0051968 positive regulation of synaptic transmission, glutamatergic
Biological Process GO:0010623 programmed cell death involved in cell development
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0043408 regulation of MAPK cascade
Biological Process GO:0051896 regulation of protein kinase B signaling
Biological Process GO:0048678 response to axon injury
Biological Process GO:0042493 response to drug
Biological Process GO:0051602 response to electrical stimulus
Biological Process GO:0051599 response to hydrostatic pressure
Biological Process GO:0035094 response to nicotine
Biological Process GO:0031667 response to nutrient levels
Biological Process GO:0009314 response to radiation
Biological Process GO:0019233 sensory perception of pain
Biological Process GO:0060009 Sertoli cell development
Biological Process GO:0048485 sympathetic nervous system development
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0005004 GPI-linked ephrin receptor activity
molecular function GO:0042802 identical protein binding
molecular function GO:0019900 kinase binding
molecular function GO:0048406 nerve growth factor binding
molecular function GO:0010465 nerve growth factor receptor activity
molecular function GO:0043121 neurotrophin binding
molecular function GO:0005166 neurotrophin p75 receptor binding
molecular function GO:0005030 neurotrophin receptor activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0004675 transmembrane receptor protein serine/threonine kinase activity
molecular function GO:0004714 transmembrane receptor protein tyrosine kinase activity
cellular component GO:0030424 axon
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0030425 dendrite
cellular component GO:0005769 early endosome
cellular component GO:0031901 early endosome membrane
cellular component GO:0000139 Golgi membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005770 late endosome
cellular component GO:0031902 late endosome membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0043235 receptor complex
cellular component GO:0055037 recycling endosome
cellular component GO:0055038 recycling endosome membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0020368 Gambogic Acid 628.3
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein