Showing entry for Amiloride-sensitive sodium channel subunit alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009961
Protein NameAmiloride-sensitive sodium channel subunit alpha
Uniport IdP37088
GeneSCNN1A
Gene Id6337
DomainASC
Pfam PF00858  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.7 Sensory system hsa04742 Taste transduction
5. Organismal Systems 5.5 Excretory system hsa04960 Aldosterone-regulated sodium reabsorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0050891 multicellular organismal water homeostasis
Biological Process GO:0050896 response to stimulus
Biological Process GO:0050909 sensory perception of taste
Biological Process GO:0055078 sodium ion homeostasis
Biological Process GO:0035725 sodium ion transmembrane transport
molecular function GO:0015280 ligand-gated sodium channel activity
molecular function GO:0050699 WW domain binding
cellular component GO:0001669 acrosomal vesicle
cellular component GO:0016324 apical plasma membrane
cellular component GO:0060170 ciliary membrane
cellular component GO:0005737 cytoplasm
cellular component GO:0070062 extracellular exosome
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0031514 motile cilium
cellular component GO:0005886 plasma membrane
cellular component GO:0034706 sodium channel complex
cellular component GO:0097228 sperm principal piece
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-382551 Transport of small molecules
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006267 BXGD000383 Bronchiectasis Respiratory Tract Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0008677 BXGD000560 Bronchitis, Chronic Infections; Respiratory Tract Diseases
C0009080 BXGD000580 Clubbed Fingers Musculoskeletal Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0013990 BXGD000874 Pathological accumulation of air in tissues Pathological Conditions, Signs and Symptoms
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018520 BXGD001197 Halitosis Pathological Conditions, Signs and Symptoms
C0019079 BXGD001278 Hemoptysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020461 BXGD001395 Hyperkalemia Nutritional and Metabolic Diseases
C0020488 BXGD001402 Hypernatremia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020621 BXGD001449 Hypokalemia Nutritional and Metabolic Diseases
C0020625 BXGD001451 Hyponatremia Nutritional and Metabolic Diseases
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027654 BXGD002010 Embryonal Neoplasm Neoplasms
C0027658 BXGD002011 Neoplasms, Germ Cell and Embryonal Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030779 BXGD002252 Pelger-Huet Anomaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0033805 BXGD002427 Pseudohypoaldosteronism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0034063 BXGD002453 Pulmonary Edema Respiratory Tract Diseases
C0034642 BXGD002485 Rales Pathological Conditions, Signs and Symptoms
C0035220 BXGD002512 Respiratory Distress Syndrome, Newborn Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0043144 BXGD003032 Wheezing Pathological Conditions, Signs and Symptoms
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0149651 BXGD003342 Clubbing
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0205851 BXGD004132 Germ cell tumor Neoplasms
C0205852 BXGD004133 Neoplasms, Embryonal and Mixed Neoplasms
C0220981 BXGD004348 Metabolic acidosis Nutritional and Metabolic Diseases
C0220983 BXGD004350 Metabolic alkalosis Nutritional and Metabolic Diseases
C0221043 BXGD004377 Liddle Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0235063 BXGD004718 Respiratory Depression Respiratory Tract Diseases
C0239134 BXGD004964 Productive Cough Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0268436 BXGD005946 Pseudohypoaldosteronism, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0339985 BXGD007296 Idiopathic bronchiectasis Respiratory Tract Diseases
C0392164 BXGD008031 Pulmonary Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740345 BXGD009979 Germ Cell Cancer Neoplasms
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751364 BXGD010412 Cancer, Embryonal Neoplasms
C0751365 BXGD010413 Cancer, Embryonal and Mixed Neoplasms
C0917798 BXGD011409 Cerebral Ischemia Nervous System Diseases; Cardiovascular Diseases
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1449842 BXGD013093 Pseudohypoaldosteronism, Type I, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1449843 BXGD013094 Pseudohypoaldosteronism, Type I, Autosomal Recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1449844 BXGD013095 Pseudohypoaldosteronism, Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1527396 BXGD013287 Fibrocystic Disease of Pancreas Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1846345 BXGD014801 Hyperactive renin-angiotensin system
C1846347 BXGD014802 Renal salt wasting
C1861403 BXGD016045 Variable expressivity
C2674608 BXGD017250 Feeding difficulties in infancy
C2713447 BXGD017501 Hyperpotassemia and Hypertension, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2751666 BXGD017732 BRONCHIECTASIS WITH OR WITHOUT ELEVATED SWEAT CHLORIDE 2 Respiratory Tract Diseases
C3163798 BXGD018516 Recurrent lower respiratory tract infection
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C4023112 BXGD021110 Acute infectious pneumonia
C4025204 BXGD021590 Recurrent Haemophilus influenzae infections
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4552938 BXGD023529 Productive Cough, CTCAE
C4748292 BXGD023997 LIDDLE SYNDROME 3
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002358 Allitridin 178.34
BXGC0002594 1,2-(2-Propenyl)-disulfane 146.27
BXGC0002599 2-Propene-1-sulfinothiocic-acids 2-propenyl ester 162.27
BXGC0002619 Di-2-propenyl-sulfane 114.21
BXGC0029111 alliin 177.05
BXGC0050318 S-allylcysteine 161.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein