Showing entry for Vitamin K-dependent gamma-carboxylase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010040
Protein NameVitamin K-dependent gamma-carboxylase
Uniport IdP38435
GeneGGCX
Gene Id2677
DomainVKG_Carbox
Pfam PF05090  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007596 blood coagulation
Biological Process GO:0006464 cellular protein modification process
Biological Process GO:0017187 peptidyl-glutamic acid carboxylation
molecular function GO:0008488 gamma-glutamyl carboxylase activity
molecular function GO:0019842 vitamin binding
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-159740 Gamma-carboxylation of protein precursors
R-HSA-159740 Gamma-carboxylation of protein precursors
R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-1643685 Disease
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-597592 Post-translational protein modification
R-HSA-9651496 Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
R-HSA-9668250 Defective factor IX causes hemophilia B
R-HSA-9671793 Diseases of hemostasis
R-HSA-9673240 Defective gamma-carboxylation of F9
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002982 BXGD000163 Angioid Streaks Eye Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0010495 BXGD000674 Cutis Laxa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0013491 BXGD000847 Ecchymosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0018924 BXGD001249 Hemarthrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0029131 BXGD002116 Abnormality of the optic nerve
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0033847 BXGD002437 Pseudoxanthoma Elasticum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0037285 BXGD002680 Skin Manifestations Pathological Conditions, Signs and Symptoms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042880 BXGD003011 Vitamin K Deficiency Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0151872 BXGD003493 Prothrombin time increased Hemic and Lymphatic Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0240671 BXGD005048 Partial thromboplastin time increased (finding)
C0272315 BXGD006341 Coagulation factor deficiency syndrome Hemic and Lymphatic Diseases
C0332563 BXGD006894 Papule Pathological Conditions, Signs and Symptoms
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0451641 BXGD008821 Urolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0473583 BXGD008946 Nevus elasticus Neoplasms
C0581342 BXGD009560 Redundant skin Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1458140 BXGD013134 Bleeding tendency Hemic and Lymphatic Diseases
C1519353 BXGD013236 Skin Papule Skin and Connective Tissue Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1833683 BXGD013938 NEPHROLITHIASIS, CALCIUM OXALATE Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1835813 BXGD014053 Pseudoxanthoma Elasticum-Like Disorder with Multiple Coagulation Factor Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C1839829 BXGD014413 Short distal phalanx of finger
C1846821 BXGD014841 Abnormality of coagulation
C1848534 BXGD014937 VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1852548 BXGD015291 Absent retinal pigment epithelium
C1854114 BXGD015383 Short nose
C1855607 BXGD015516 Keutel syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C1859126 BXGD015854 Stippled epiphyses
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3278975 BXGD018749 Attenuation of retinal blood vessels
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4023159 BXGD021128 Reduced factor IX activity
C4024702 BXGD021377 Reduced factor X activity
C4024722 BXGD021385 Reduced factor VII activity
C4024853 BXGD021440 Increased number of skin folds
C4476540 BXGD022824 Dilatation of the cerebral artery Nervous System Diseases; Cardiovascular Diseases
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
BXGC0012321 Menatetrenone 444.66
BXGC0024665 Vitamin K 1 450.35
BXGC0044200 Menadione 172.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein